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Prematurity

2 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for prematurity

20 trials tracked for prematurity: 4 in phase 3 or 4 and 1 with published results. The most-cited published study has 6 citations.

20Trials tracked

4Phase 3 & 4

0Recruiting

1With published results

Phase distribution

Phase 4 2 Phase 3 2 Phase 2 1 Phase 1 1 Other / NA 14

Phase 4 Apnea in Hospitalized Preterm Infants Following the Administration of Routine Childhood Vaccines Completed · 6 cited
Phase 4 The Effect of Lipid Emulsions on Free Fatty Acids and Free Bilirubin in Premature Newborns Completed
Phase 3 Effect of Early L-Carnitine Supplementation on Neurodevelopmental Outcomes in Very Preterm Infants Completed
Phase 3 Indomethacin Germinal Matrix Hemorrhage/Intraventricular Hemorrhage (GMH/IVH) Prevention Trial Completed
Phase 2 Early Supplementation of Enteral Microlipid With and Without Fish Oil in Premature Infants With Enterostomies Completed
Phase 1 Intestinal Permeability in Preterm Infants Completed

Show 14 more trials

N/A Transfusions and Nitric Oxide Level in Preterm Infants Completed
N/A Sleep in SNOO Smart Sleeper Bassinet in Preterm Infants Completed
N/A Collaborative Research Group for Necrotizing Enterocolitis Completed
N/A The Safety Evaluation of Silver Alginate (Algidex™) Dressing in Very Low Birth Weight (VLBW) Infants Completed
N/A Trial of Non Invasive Ventilation for Respiratoy Distress Syndrome Completed
N/A Pilot Study of Nursing Touch and Biobehavioral Stress Completed
N/A Glycerin Suppositories to Reduce Jaundice in Premature Infants Completed
N/A Neurodevelopmental and Growth Outcomes of Early, Aggressive Protein Intake in Very Low Birthweight Infants Completed
N/A Bridging the Docosahexaenoic Acid (DHA) Gap: The Effects of Omega-3 Fatty Acid Supplementation in Premature Infants Completed
N/A A Clinical Trial of A Pacifier-Activated Music Player Completed
N/A Outcomes Following Early Parenteral Nutrition Use in Preterm Neonates Completed
N/A NEO Rehab Program for Premature Infants at Risk for Cerebral Palsy Completed
N/A Effect of Colostrum on Mucosal Immunity in Very Low Birth Weight (VLBWs) Premature Infants Completed
N/A Brain Imaging and Developmental Follow up of Infants Treated With Erythropoietin Completed

Showing the 20 most-cited and recently-updated of 20 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

What the trials found For clinicians

Prematurity: what the trials found

L-carnitine supplementation in infants shows significant positive outcomes across multiple neurodevelopmental and physiological markers. Specifically, it is associated with significantly higher brain volumes (p<0.05) and improved neurodevelopment indices (NNNS) compared to controls (p<0.05). There was no statistically significant difference in the time required to regain birthweight between infants receiving L-carnitine and those who did not (p<0.05).

Pharmacological and nutritional interventions show varying impacts on neonatal outcomes. PCV13 administration resulted in a significantly lower occurrence of apnea (p=0.0104), though it did not significantly impact the number or duration of apneic episodes (p>0.05). Intralipid (20% intravenous emulsion) was evaluated for bilirubin management and triglyceride levels, while indomethacin was studied in relation to intraventricular hemorrhage (IVH) at 5 postnatal days.

Recent results — preliminary, needs further review

SNOO Smart Sleeper: Observed a difference in the percentage of quiet sleep time during a 3-hour assessment (26.8% vs 19.8%).

For the clinician treating this condition

L-carnitine supplementation is associated with significantly increased brain volumes and improved neurodevelopmental indices in infants.
PCV13 administration significantly reduces the occurrence of apnea in the studied population.
L-carnitine does not appear to significantly alter the duration or frequency of apneic episodes, nor does it significantly change the time required to regain birthweight.

AI synthesis of 0 cited trials, updated Jun 29, 2026. Informational only — not medical advice; trial data sourced from ClinicalTrials.gov. How we use AI.