Mode
Home
Research
Clinical Trials Drug Pipeline Weekly Digests
Reference
Conditions Medications
Community
Questions
Text Size
Log in / Sign up
Home › Conditions › Progressive familial intrahepatic cholestasis

Progressive familial intrahepatic cholestasis

1 published article · Updated continuously

Clinical Trial Landscape

Clinical Trials for Progressive familial intrahepatic cholestasis

2 trials tracked for Progressive familial intrahepatic cholestasis: 1 in phase 3 or 4 and 1 with published results. The most-cited published study has 31 citations.

2Trials tracked
1Phase 3 & 4
0Recruiting
1With published results
Phase distribution
Phase 3 1 Phase 2 1
  1. Phase 3 Long Term Safety & Efficacy Study Evaluating The Effect of A4250 in Children With PFIC Completed · 31 cited
  2. Phase 2 A Study to Evaluate the Safety and Tolerability of Maralixibat in Infant Participants With Cholestatic Liver Diseases Including Progressive Familial Intrahepatic Cholestasis (PFIC) and Alagille Syndrome (ALGS). Completed

Showing the 2 most-cited and recently-updated of 2 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
PFIC null genotype linked to 2.79-fold higher odds of liver transplantation
Gastroenterology Meta-analysis
PFIC null genotype linked to 2.79-fold higher odds of liver transplantation PFIC null genotype linked to higher liver transplant risk
This meta-analysis of observational studies including 420 PFIC patients found a close association between null genotype and liver transplant…
A meta-analysis of 420 patients found a strong link between a specific genetic variant and the need for liver transplants in progressive fam…
Jun 2, 2026