Research across Cancer
Related studies from across the Cancer family.
Robotic ISR shows better anal function and fewer complications than laparoscopic approach
Robotic surgery shows better anal function for low rectal cancer
A meta-analysis finds robotic intersphincteric resection improves anal function and reduces complications versus laparoscopic surgery for lo…
A review of 1,279 patients found robotic surgery for low rectal cancer led to better anal function and fewer complications than laparoscopic…
Review of sphincter-preserving techniques for ultra-low rectal cancer
New surgery keeps bowel control for ultra-low rectal cancer patients
This narrative review synthesizes evidence on six sphincter-preserving techniques for ultra-low rectal cancer. The authors report satisfacto…
A new surgical approach for ultra-low rectal cancer may better preserve bowel control and reduce the need for a permanent colostomy.
TaTME shows lower conversion rates with similar short-term safety compared to LapTME for low rectal cancer
New surgical approach for rectal cancer cuts conversion rate
This randomized trial compared transanal total mesorectal excision with laparoscopic total mesorectal excision for patients with low rectal …
A new surgical technique for rectal cancer reduces the need to switch to open surgery, with similar complication rates.
S-1 plus oxaliplatin consolidation shows low toxicity in stage II/III lower rectal cancer patients
First study reports SOX consolidation for lower rectal cancer
This Phase I study enrolled 12 patients with stage II/III lower rectal adenocarcinoma.
A small early trial found SOX chemotherapy was safe after radiation for lower rectal cancer, with surgery completed on time for all patients…
Retrospective analysis finds sarcopenia associated with shorter disease-free survival in pancreatic neuroendocrine tumor patients
Low muscle mass linked to shorter disease-free survival in pancreatic tumor patients
This retrospective cohort study included 86 patients who underwent curative-intent resection for pancreatic neuroendocrine tumors.
Low muscle mass before surgery was linked to shorter disease-free survival in patients with pancreatic neuroendocrine tumors, though this li…
Nivolumab plus ipilimumab versus nivolumab in advanced neuroendocrine carcinoma phase II trial
New Combo Shows Modest Promise for Hard-to-Treat Neuroendocrine Cancers
This randomized phase II trial enrolled 185 patients with advanced neuroendocrine carcinoma refractory to platinum-based chemotherapy.
For patients with rare, aggressive neuroendocrine cancers that resist initial treatment, this study offers a new, though modest, combination…
Meta-analysis identifies germline susceptibility loci for rare cancers including MDS and GIST
Genes linked to rare cancers found in large study of over 480,000 people
This meta-analysis of observational cohorts from over 480,000 individuals identified novel germline susceptibility loci for rare cancers.
A huge study of over 480,000 people found new genes that raise the risk of several rare cancers, offering clues for families and doctors.
Phase II RCT finds no benefit for adding capecitabine to 177Lu-Dotatate in advanced NETs
Adding a Drug Actually Hurted These Patients
A Phase II randomized controlled trial in 111 patients with advanced somatostatin receptor-positive GEP or bronchopulmonary NETs compared…
Adding a common chemotherapy drug to cancer treatment actually made tumors grow faster and reduced survival time for these patients.
Meta-analysis of splenic-preserving vs splenectomy distal pancreatectomy for resectable body/tail pNETs
Meta-analysis suggests splenic-preserving surgery may reduce complications for certain pancreatic tumors
This systematic review and meta-analysis evaluated splenic-preserving distal pancreatectomy (SPDP) versus distal pancreatectomy with splenec…
Keeping the spleen during pancreatic surgery led to less blood loss, fewer complications, shorter hospital stays, and lower transfusion need…
![In a phase 2 trial, [Ga]Ga-SSO120 PET/CT detected malignancies in 18 of 19 patients with small cell or large cell neuroendocrine lung cancer](https://images.unsplash.com/photo-1766297247924-6638d54e7c89?crop=entropy&cs=tinysrgb&fit=max&fm=jpg&ixid=M3w5MDg5NDR8MHwxfHNlYXJjaHw5fHxtZWRpY2FsJTIwcmVzZWFyY2glMjBzY2llbmNlfGVufDF8MHx8fDE3NzU4ODUyMzd8MA&ixlib=rb-4.1.0&q=80&w=1080)
In a phase 2 trial, [Ga]Ga-SSO120 PET/CT detected malignancies in 18 of 19 patients with small cell or large cell neuroendocrine lung cancer
A New Scan That Lights Up Hidden Lung Cancer Spread
This prospective, phase 2, cross-sectional imaging trial evaluated [Ga]Ga-SSO120 PET/CT versus CT in 19 patients with small cell lung cancer…
A new kind of PET scan found hidden tumors in patients with aggressive lung cancer, including bone and brain spread that standard imaging mi…
Intratumoral H101 plus total neoadjuvant therapy yields pathologic complete response in one patient with metachronous locally advanced rectal cancer
Could a virus help save a patient's rectal cancer and their ability to use the bathroom?
This case report describes a 50-year-old patient with metachronous locally advanced rectal cancer treated with intratumoral injection of rec…
A virus combined with standard therapy helped a 50-year-old man clear his rectal cancer while keeping his bowel control intact.
Axitinib + Octreotide Shows PFS Benefit in Extrapancreatic NETs per Central Review (HR 0.71)
Can a blood vessel blocker help slow rare gut tumors? Study shows mixed results for new combination treatment
In the AXINET phase II/III trial, axitinib plus octreotide LAR significantly improved median PFS per blinded independent central review (16.…
A new blood vessel blocker combined with standard hormone shots helped rare gut tumors shrink and delayed growth longer than placebo, despit…