Mode
Text Size
Log in / Sign up

Seborrheic keratosis

1 published article · Updated continuously

Clinical Trial Landscape

Clinical Trials for Seborrheic keratosis

8 trials tracked for Seborrheic keratosis: 4 in phase 3 or 4 and 2 with published results. The most-cited published study has 14 citations.

8Trials tracked
4Phase 3 & 4
0Recruiting
2With published results
Phase distribution
Phase 4 1 Phase 3 3 Phase 2 3 Other / NA 1
  1. Phase 3 A Randomized, Double-Blind, Vehicle-Controlled Study in Subjects With Seborrheic Keratosis Completed · 14 cited
  2. Phase 3 A Study of A-101 Solution 40% in Subjects With Seborrheic Keratosis. Completed · 14 cited
  3. Phase 4 An A Study Assessing Subject Satisfaction With A-101 Topical Solution for Seborrheic Keratoses Completed
  4. Phase 3 An Open-Label Safety Study of A-101 Solution Completed
  5. Phase 2 A Randomized, Vehicle-Controlled Study of 2 Concentrations of A-101 for the Treatment of Seborrheic Keratosis Completed
  6. Phase 2 Study of A-101 for the Treatment of Seborrheic Keratosis Completed
Show 2 more trials
  1. Phase 2 Dose-Response Profile of A-101 in Subjects With Seborrheic Keratosis Completed
  2. N/A Nano-Pulse Stimulation (NPS) in Seborrheic Keratosis Study Completed

Showing the 8 most-cited and recently-updated of 8 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

What the trials found For clinicians

Seborrheic keratosis: what the trials found

Clinical trials evaluating the A-101 solution for seborrheic keratosis demonstrate various measures of efficacy. In a Phase 2 study, the mean percentage of target lesions judged to be clear (PLA=0) at Visit 8 reached 3.72, 49.5, and 57.88 across different treatment arms 5.

Additional Phase 3 trials involving A-101 solution reported a 56% clearance rate for lesions 3. In a separate Phase 2 trial, the percentage of PLA responders with target lesions judged clear at Visit 8 was 22, 18, and 1 across the respective arms (p<0.0001), with corresponding mean changes from baseline in PLA scores of -1.7, -1.4, and -0.1 (p<0.0001) 7.

A Phase 4 study assessing A-101 Topical Solution reported a correlation of 0.318 between the Physician Lesion Assessment (PLA) score and patient satisfaction 1. Multiple Phase 3 trials were conducted to evaluate the A-101 solution [2, 4].

Recent results — preliminary, needs further review

  • Nano-Pulse Stimulation (NPS) was evaluated in a study for seborrheic keratosis, but results are not yet corroborated 8.
  • A study using an A-101 Vehicle showed significant changes in Physician Lesion Assessment (PLA) scores from baseline to Visit 8 (-0.32, -0.77, -0.91; p=0.0001) and a significant proportion of subjects with at least 3 of 4 target lesions judged clear (p=0.0016), though these findings are not yet corroborated 6.

For the clinician treating this condition

  • A-101 solution has been evaluated in multiple Phase 2 and Phase 3 trials with varying reported clearance rates and PLA score improvements [3, 5, 7].
  • There is a documented correlation between Physician Lesion Assessment (PLA) scores and patient satisfaction in a Phase 4 study of A-101 Topical Solution 1.

AI synthesis of 6 cited trials, updated Sep 9, 2026. Informational only — not medical advice; trial data sourced from ClinicalTrials.gov. How we use AI.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.