Gut microbiota dysbiosis and microbial metabolites impair renal function in sepsis-associated acute kidney injury
Sepsis may damage kidneys by letting gut bacteria toxins leak into the blood
This narrative review examines the role of gut microbiota dysbiosis in sepsis-associated acute kidney injury and acute kidney injury. The au…
A review suggests that sepsis changes gut bacteria, causing harmful toxins to leak and hurt kidneys in humans and animals.
Higher BUN/Cr ratio linked to increased mortality in older patients with sepsis-associated AKI
A Simple Blood Test Ratio Could Predict Survival in Severe Infections
A retrospective cohort study of 764 patients aged ≥50 years with sepsis-associated AKI found each 1-unit increase in BUN/Cr ratio was associ…
A simple blood test ratio linked to kidney failure in severe infections now helps doctors predict which patients face higher survival risks.
Research across Kidney Diseases
Related studies from across the Kidney Diseases family.
Ambulatory hypertension in pediatric chronic kidney disease patients increases risk of left ventricular hypertrophy
High Blood Pressure Linked to Heart Changes in Children
This meta-analysis of 51 studies involving 6509 children with chronic kidney disease found that ambulatory hypertension is associated with i…
New data shows a strong link between high blood pressure and heart muscle thickening in children with chronic kidney disease.
Roxadustat increases odds of vascular access thrombosis and all-cause mortality in patients with chronic kidney disease
Roxadustat Linked to Higher Risk of Blood Clots in Kidney Patients
This systematic review and meta-analysis of 11,418 adults with chronic kidney disease found that roxadustat is associated with higher odds o…
A review of over 11,000 patients suggests roxadustat may increase the risk of blood clots and death for those with chronic kidney disease.
Cystatin C shows good diagnostic performance with an AUC of 0.88 for early detection of SA-AKI
Cystatin C shows promise for early detection of kidney injury
This meta-analysis of 17 studies evaluates the diagnostic performance of Cystatin C for detecting acute kidney injury in patients with sepsi…
A new look at 17 studies suggests that Cystatin C could help doctors identify kidney damage in sepsis patients much earlier than current met…
Semaglutide reduces risk of kidney decline or death in type 2 diabetes and CKD
Semaglutide lowers kidney and heart risks in type 2 diabetes patients
This randomized controlled trial enrolled 3,533 participants with type 2 diabetes and chronic kidney disease. Once-weekly subcutaneous semag…
A large trial shows once-weekly semaglutide reduces kidney failure and death risks in people with type 2 diabetes and chronic kidney disease…
Jinlida Granule reduces serum creatinine and HbA1c in diabetic kidney disease patients across a meta-analysis
Jinlida Granule lowers key kidney markers in diabetic kidney disease patients
This systematic review and meta-analysis evaluated Jinlida Granule for diabetic kidney disease in 1,341 patients. The pooled analysis showed…
A large review of 1,341 patients found Jinlida Granule significantly lowered kidney stress markers and blood sugar levels compared to standa…
Steroid avoidance may reduce death and diabetes after kidney transplant but raises rejection risk
Steroid avoidance after kidney transplant may reduce death and diabetes
This systematic review of 53 studies (8317 participants) found that steroid avoidance may reduce all-cause death at 1-5 years and post-trans…
Skipping steroids after a kidney transplant might lower the risk of death and diabetes, but could raise the chance of rejection.
ILC dysregulation and gut microbiota dysbiosis may drive kidney disease via the microbiota-gut-kidney axis
Gut bacteria imbalance may drive kidney disease inflammation
This narrative review explores the proposed role of ILC dysregulation and gut-derived metabolic signals in chronic kidney disease. The autho…
A new review suggests that imbalances in gut bacteria and immune cells might explain why kidney disease causes inflammation. This points to …
Fluoroless ultrasound-guided techniques lower complications in percutaneous nephrolithotomy with equivalent stone-free rates
Fluoroless ultrasound guidance reduces complications during kidney stone surgery
This systematic review and meta-analysis of randomized studies evaluated fluoroless ultrasound-guided versus fluoroscopy-guided techniques f…
A meta-analysis of randomized trials shows that using ultrasound instead of X-ray guidance lowers overall complications for kidney stone rem…
ECIRS triples stone-free odds versus PCNL in large kidney stones, meta-analysis finds
New surgery clears kidney stones better than the standard method without more risk
This systematic review and meta-analysis of 1988 patients with high stone burden found that endoscopic combined intrarenal surgery (ECIRS) s…
A new analysis shows a specific surgery clears kidney stones faster and with fewer complications than the standard approach for tough cases.
Kidney transplantation reduces left-ventricular mass index by 22 g/m² in end-stage kidney disease
Kidney transplant reverses heart damage in kidney disease patients
This meta-analysis of 33 observational studies (2364 patients) found that kidney transplantation significantly reduces left-ventricular mass…
A kidney transplant can reverse heart muscle thickening in end-stage kidney disease patients, new analysis shows.
Chronic kidney disease linked to shorter leukocyte telomere length in meta-analysis
Chronic kidney disease patients have shorter telomeres than healthy controls
This meta-analysis of case-control and pooled data found that chronic kidney disease is associated with shorter leukocyte telomere length. T…
People with chronic kidney disease show shorter telomeres than healthy people, a sign of faster biological aging linked to their disease.
Education and behavior interventions reduce burden for CKD caregivers in a systematic review
Brief programs may ease burden for CKD family caregivers
This systematic review and meta-analysis examined informal caregivers of people with chronic kidney disease. Twelve studies identified a sig…
A review of thirteen studies suggests brief education and behavior programs may reduce burden for family caregivers of people with chronic k…