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Home › Conditions › Severe Combined Immunodeficiency

Severe Combined Immunodeficiency

Part of Inborn error of immunity

1 published article · Updated continuously

Clinical Trial Landscape

Clinical Trials for Severe Combined Immunodeficiency

5 trials tracked for Severe Combined Immunodeficiency: 1 in phase 3 or 4.

5Trials tracked
1Phase 3 & 4
0Recruiting
0With published results
Phase distribution
Phase 3 1 Phase 2 4
  1. Phase 3 EZN-2279 in Patients With ADA-SCID Completed
  2. Phase 2 MND-ADA Transduction of CD34+ Cells From Children With ADA-SCID Completed
  3. Phase 2 Fludarabine Phosphate, Melphalan, and Low-Dose Total-Body Irradiation Followed by Donor Peripheral Blood Stem Cell Transplant in Treating Patients With Hematologic Malignancies Completed
  4. Phase 2 Gene Transfer for Severe Combined Immunodeficiency, X-linked (SCID-X1) Using a Self-inactivating (SIN) Gammaretroviral Vector Completed
  5. Phase 2 Conditioning Regimen for Allogeneic Hematopoietic Stem-Cell Transplantation Completed

Showing the 5 most-cited and recently-updated of 5 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
HSCT in AK2-Related Reticular Dysgenesis: 85.7% Survival at 10 Years
Allergy & Immunology Cohort
HSCT in AK2-Related Reticular Dysgenesis: 85.7% Survival at 10 Years Rare Immune Disorder: Early Transplant Restores Immunity in Newborns
This retrospective observational cohort study from a single high-consanguinity center evaluated 10 patients with AK2-related reticular dysge…
Early stem cell transplants may save babies with a rare immune disorder, restoring immunity and hearing stability in a small study.
Frontiers Apr 24, 2026

Research across Inborn error of immunity

Related studies from across the Inborn error of immunity family.

CRISPR SGE platform maps functional impact of 470 IL2RG variants in X-linked severe combined immunodeficiency
Genetics & Precision Medicine
CRISPR SGE platform maps functional impact of 470 IL2RG variants in X-linked severe combined immunodeficiency New tool maps genetic errors that break immune system cells
This article describes a CRISPR-targeted saturation genome editing (SGE) platform used to map functional impact of variants in X-linked seve…
A new method mapped 470 genetic changes in immune cells, confirming 90 that stop the cells from working properly.
medRxiv Apr 30, 2026