Cross-Sectional Analysis of Cardiac Structure and Function in 57 Adults With Sickle Cell Disease
Heart Risk Found in Young Sickle Cell Patients
This observational, cross-sectional study assessed echocardiographic profiles in 57 adults with confirmed Sickle Cell Disease at a tertiary …
Young adults with sickle cell disease often show early signs of heart strain, explaining why some feel tired or short of breath even when ot…
POCUS-guided assessments and serial exchange transfusions improved outcomes in a 20-year-old male with sickle cell disease and acute chest syndrome.
Bedside Ultrasound Saves Sickle Cell Lives
This single case report describes a 20-year-old male with HbSS, acute chest syndrome, and acute pulmonary hypertension managed in the ICU. U…
A simple ultrasound at the bedside can tell doctors exactly when a sickle cell patient needs another blood transfusion to save their life.
Renizgamglogene autotemcel infusion showed engraftment and hemoglobin increases in severe sickle cell disease patients.
One Gene Edit Stopped Painful Sickle Cell Crises in Most Patients
This single-group, open-label, multicenter Phase 1-2 trial enrolled 28 patients with severe sickle cell disease aged 12 to 50 years. Followi…
A single infusion of CRISPR-edited stem cells eliminated painful sickle cell crises in 27 out of 28 patients by switching the body back to p…
Proteogenomic analysis in sickle cell disease identifies 560 pQTL and prioritizes five proteins for HbF investigation
Study maps genetic links to blood proteins in sickle cell disease patients
An observational proteogenomic analysis of 343 sickle cell disease (SCD) patients identified 560 protein quantitative trait loci (pQTL), inc…
A study of sickle cell disease patients identified 560 genetic links to blood proteins, including 58 new ones, with five proteins potentiall…
Delayed consultation and sickle cell disease associated with poor outcomes in pediatric osteomyelitis in Cameroon
Study in Cameroon finds delayed care linked to worse bone infection outcomes in children
A retrospective cross-sectional study of children with hematogenous osteomyelitis at five referral hospitals in Douala, Cameroon, found dela…
Children in Cameroon who waited over three months for care faced much higher risks of chronic infections, lasting problems, and long antibio…
Sickle cell disease birth prevalence examined in newborns from high social vulnerability counties
Study examines sickle cell disease birth rates in areas with high social vulnerability
An observational report examined sickle cell disease birth prevalence among newborns born to mothers in counties with high social vulnerabil…
Sickle cell disease birth rates were studied in high-risk U.S. counties, focusing on social factors like poverty and transportation access.
L-arginine shows no significant benefit for pain or hospital outcomes in sickle cell disease meta-analysis
L-arginine shows no clear benefit for sickle cell pain crises in analysis
A systematic review and meta-analysis of 8 RCTs involving 830 patients with sickle cell disease found no statistically significant benefit o…
A new analysis of eight trials found that the supplement L-arginine offers no benefit for pain or hospital stays in sickle cell disease pati…