Mode
Text Size
Log in / Sign up

Skin Neoplasms

Part of Cancer

1 published article · Updated continuously

Clinical Trial Landscape

Clinical Trials for Skin Neoplasms

5 trials tracked for Skin Neoplasms: 2 in phase 3 or 4 and 1 with published results. The most-cited published study has 22 citations.

5Trials tracked
2Phase 3 & 4
0Recruiting
1With published results
Phase distribution
Phase 4 2 Phase 2 2 Other / NA 1
  1. Phase 4 CSP #562 - The VA Keratinocyte Carcinoma Chemoprevention Trial Completed · 22 cited
  2. Phase 4 Study Evaluating the Effect of Sirolimus on Non-Melanoma Skin Cancer in Kidney Transplant Recipients Completed
  3. Phase 2 Anti-Angiogenesis Agent AG-013736 In Patients With Metastatic Melanoma Completed
  4. Phase 2 5-fluorouracil Versus Placebo in Periocular Full Thickness Skin Grafts Completed
  5. N/A Safety and Performance Evaluation of the Topical Hemostatic Device (AC5™) Following Excision of Skin Lesions Completed

Showing the 5 most-cited and recently-updated of 5 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

What the trials found For clinicians

Skin Neoplasms: what the trials found

Clinical evidence regarding the management of skin neoplasms includes data on 5-fluorouracil and sirolimus. For patients treated with 5-fluorouracil, there was no statistically significant difference in the time to diagnosis of the first keratinocyte carcinoma (KC) on the face or ears requiring surgery (p=0.93), nor was there a significant difference in the hazard ratio for surgically treated KC (p=0.93).

Sirolimus demonstrated significant efficacy in reducing new biopsy-confirmed nonmelanoma skin cancer (NMSC) lesions per subject per year (1.31 vs 2.48, p=0.022). Furthermore, sirolimus was associated with a significantly shorter time to the first biopsy-confirmed new NMSC lesion (380 vs 163 days, p=0.047) and a higher number of lesion-free subjects (17 vs 9, p=0.015).

Recent results — preliminary, needs further review

  • Axitinib [AG-013736] showed an objective response rate of 18.8% in a small cohort, but this finding is not yet corroborated.
  • The AC5 Topical Hemostatic Device was evaluated for wound management; however, results regarding its specific efficacy in skin neoplasms are not yet corroborated.

For the clinician treating this condition

  • Sirolimus significantly reduces the annual rate of new biopsy-confirmed NMSC lesions and increases the number of lesion-free subjects.
  • 5-fluorouracil did not demonstrate a statistically significant impact on the timing or hazard ratio for surgically treated keratinocyte carcinomas on the face or ears.

AI synthesis of 0 cited trials, updated Jun 29, 2026. Informational only — not medical advice; trial data sourced from ClinicalTrials.gov. How we use AI.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.

Research across Cancer

Related studies from across the Cancer family.