Meta-analysis shows active surveillance and ablative therapy for small renal masses have comparable cancer-specific survival
Active surveillance vs ablation for small kidney tumors: what works?
This systematic review and meta-analysis evaluates active surveillance (AS) versus ablative therapy (AT) for patients with small renal masse…
For small kidney tumors, ablation may boost survival, but cancer-specific death risk is similarly low with either approach.
Prospective study shows active surveillance yields high survival for small renal masses under 2 cm
Small kidney tumors may not need surgery right away
This prospective multi-institutional study evaluated active surveillance in patients aged over 50 years with asymptomatic, unilateral small …
Many small kidney tumors stay harmless for years, meaning patients might avoid surgery and its risks without putting their health in danger.
Research across Urologic Neoplasms
Related studies from across the Urologic Neoplasms family.
Low CALLY index is associated with worse progression-free survival and overall survival in renal cell carcinoma
CALLY index helps predict survival for kidney cancer patients
This meta-analysis of five retrospective cohort studies indicates that a low C-reactive protein-albumin-lymphocyte (CALLY) index correlates …
A specific blood marker called the CALLY index may help doctors predict how well patients with kidney cancer will respond to treatment.
Novel TCEB1 variants identified in a case of renal cell carcinoma via NGS and IHC
Single Case Ties Rare TCEB1 Mutation to Kidney Cancer
This case report and literature review describes the identification of two somatic TCEB1 variants in a patient with a left renal mass. The f…
A 52-year-old man's kidney tumor carried a never-before-reported TCEB1 mutation, a finding that may help doctors spot this rare cancer type.
PD-L1 and CTLA-4 Variants Linked to Genitourinary Cancer Risk
Genetic variations linked to risk of certain genitourinary cancers
A meta-analysis of 16 studies links PD-L1 and CTLA-4 variants to altered genitourinary cancer susceptibility, especially in Asian population…
Specific genetic markers in the PD-L1 and CTLA-4 genes are linked to different levels of risk for bladder, kidney, and prostate cancers.
Hugo RAS system shows no significant difference from other platforms in partial nephrectomy for renal cell carcinoma
Hugo RAS system shows similar results to other kidney surgeries
This meta-analysis of observational studies evaluates the Hugo RAS system compared to the da Vinci platform and traditional laparoscopy for …
A new surgical robot platform shows similar safety and recovery results to traditional methods for kidney cancer surgery.
PFS and ORR fall short as OS surrogates in metastatic RCC
Analysis shows limitations in using certain metrics to predict cancer survival
In metastatic RCC, PFS and ORR show only moderate correlation with OS, with surrogate thresholds that are not statistically significant.
A large analysis of kidney cancer cases suggests that common clinical markers may not reliably predict how long a patient will live.
Immune dysfunction involving multiple cell types creates an immunosuppressive microenvironment in clear cell renal cell carcinoma
Immune Checkpoint Inhibitors and Immune Dysfunction in Kidney Cancer
This narrative review examines the role of immune dysfunction in clear cell renal cell carcinoma (ccRCC). It identifies how various immune c…
New research highlights how specific immune cells create a protective shield for kidney cancer, potentially making it harder for treatments …
Pazopanib and Axitinib Linked to Probable Cholecystitis in Renal Cell Carcinoma Case
Kidney cancer drugs may cause gallbladder inflammation in some patients
This case report and literature review describes a 74-year-old man with renal cell carcinoma who developed cholecystitis 4 weeks after start…
A 74-year-old man developed gallbladder inflammation after taking two specific drugs for kidney cancer, highlighting a need for closer monit…
Sutureless renorrhaphy is noninferior to conventional renorrhaphy for trifecta achievement in robot-assisted partial nephrectomy
Sutureless Technique Shows No Difference in Renal Cancer Surgery
This meta-analysis of 787 patients evaluated sutureless renorrhaphy versus conventional renorrhaphy in robot-assisted off-clamp partial neph…
A sutureless technique for closing the kidney during surgery shows similar results to traditional methods for patients with renal cancer.
Belzutifan and Lenvatinib Combination Improves Progression Free Survival in Advanced Renal Cell Carcinoma
Trial shows new drug combo slows advanced kidney cancer growth
A Phase 3 trial demonstrates that the belzutifan-lenvatinib combination significantly extends progression-free survival in patients with adv…
A new drug combination helped slow the growth of advanced kidney cancer in patients who did not respond to earlier treatments.
First-line immune checkpoint inhibitors plus anti-angiogenic therapy improve progression-free survival and response rates in advanced RCC
Combination Therapy Shows Better Outcomes for Advanced Renal Cell Carcinoma
This meta-analysis of 4,977 patients found that first-line immune checkpoint inhibitors combined with anti-angiogenic therapy significantly …
A new combination of immune checkpoint inhibitors and anti-angiogenic therapy shows better survival rates than standard treatment for advanc…
cGAS-STING pathway activation drives inflammation, fibrosis, and podocyte injury in various kidney diseases
New research identifies a key pathway in kidney disease progression
This systematic review synthesizes preclinical data on the cGAS-STING signaling pathway's role in acute kidney injury, chronic kidney diseas…
A specific signaling pathway called cGAS-STING acts as a central hub, linking inflammation and metabolism to several types of serious kidney…
Comparative Efficacy of Robot Assisted Radical Nephrectomy and Open Surgery for IVC Thrombus
Robot assisted surgery shows fewer complications for certain kidney cancers
Meta-analysis indicates robot-assisted radical nephrectomy reduces blood loss, transfusion needs, and major complications in patients with r…
Robotic surgery may reduce blood loss and hospital stays for patients with specific types of kidney cancer involving the inferior vena cava.