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Home › Conditions › Spasticity

Spasticity

5 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Spasticity

18 trials tracked for Spasticity: 12 in phase 3 or 4 and 2 with published results. The most-cited published study has 24 citations.

18Trials tracked
12Phase 3 & 4
0Recruiting
2With published results
Phase distribution
Phase 4 3 Phase 3 9 Phase 2 3 Other / NA 3
  1. Phase 3 MEDITOXIN® Versus BOTOX® in the Treatment of Post-stroke Spasticity of the Upper Limb Spasticity Completed · 24 cited
  2. Phase 3 Dose-response Study of Efficacy and Safety of Botulinum Toxin Type A to Treat Spasticity of the Arm(s) or of Arm(s) and Leg(s) in Cerebral Palsy Completed · 19 cited
  3. Phase 4 Imaging of 3D Innervation Zone Distribution in Spastic Muscles From High-density Surface EMG Recordings Completed
  4. Phase 4 Comparative Efficacy of Three Preparations of Botox-A in Treating Spasticity Completed
  5. Phase 4 A Randomized Study of Sativex on Cognitive Function and Mood: Multiple Sclerosis Patients Completed
  6. Phase 3 Safety Study of SPARC1104 Completed
Show 12 more trials
  1. Phase 3 Efficacy and Safety of SPARC0921 in Subjects With Spasticity Completed
  2. Phase 3 A Study of the Safety and Effectiveness of Sativex®, for the Relief of Symptoms of Spasticity in Subjects, From Phase B, With Multiple Sclerosis (MS) Completed
  3. Phase 3 A Study of Sativex® for Relief of Spasticity in Subjects With Multiple Sclerosis. Completed
  4. Phase 3 A Long-term Safety Extension Study of Delta-9-tetrahydrocannabinol (THC) and Cannabidiol (CBD) in Multiple Sclerosis Completed
  5. Phase 3 Evaluate the Maintenance of Effect After Long-term Treatment With Sativex® in Subjects With Symptoms of Spasticity Due to Multiple Sclerosis Completed
  6. Phase 3 A Study of the Long-term Safety of Sativex Use Completed
  7. Phase 2 A Study to Define the ECG Effects of Tizanidine Compared to Placebo and the Positive Control, Moxifloxacin, in Healthy Men and Women Using a Blinded ECG Evaluator: A Thorough ECG Trial Completed
  8. Phase 2 Study of SPARC1103 in Subjects With Spasticity Completed
  9. Phase 2 Developing and Testing a Comprehensive MS Spasticity Management Program Completed
  10. N/A Spinal Cord Stimulation to Augment Activity Based Therapy Completed
  11. N/A Compare Two Guidance Techniques for Botulinum Toxin Injections for the Treatment of Limb Spasticity and Focal Dystonia Completed
  12. N/A Repetitive Transcranial Magnetic Stimulation (rTMS) Treatment of Post-Stroke Spasticity Completed

Showing the 18 most-cited and recently-updated of 18 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Meta-analysis shows repetitive peripheral magnetic stimulation effects on stroke motor recovery
Neurology Meta-analysis
Meta-analysis shows repetitive peripheral magnetic stimulation effects on stroke motor recovery New rules for magnetic therapy boost arm recovery after stroke
This meta-analysis of 14 trials involving 580 stroke patients evaluates the effects of repetitive peripheral magnetic stimulation (rPMS) on …
New magnetic therapy rules help stroke patients regain arm strength faster when used for the right length of time
Frontiers Apr 30, 2026
Narrative review evaluates muscle energy techniques for post-stroke spasticity management
Neurology Sys. Review
Narrative review evaluates muscle energy techniques for post-stroke spasticity management Gentle Hands-On Therapy Eases Arm Stiffness After Stroke
This review examines muscle energy techniques for post-stroke spasticity in persons with stroke, though evidence strength is limited.
A gentle hands-on therapy called muscle energy techniques may reduce arm stiffness and improve movement after stroke, but it requires active…
Frontiers Apr 28, 2026
Systematic review finds preliminary evidence for brain stimulation in post-stroke pain
Neurology Sys. Review
Systematic review finds preliminary evidence for brain stimulation in post-stroke pain Stroke Survivors Feel Pain Long After. Brain Zaps May Help
A systematic review examined invasive and non-invasive brain stimulation techniques for individuals with post-stroke pain, including spastic…
Gentle brain zaps may soften the burning pain and tight muscles that linger long after a stroke ends, offering hope for survivors.
Frontiers Apr 16, 2026
Botulinum toxin injections and neuromodulation show therapeutic potential for post-stroke limb spasticity
Neurology RCT
Botulinum toxin injections and neuromodulation show therapeutic potential for post-stroke limb spasticity Review finds botulinum toxin injections help reduce post-stroke limb spasticity
This narrative review analyzed 68 studies involving patients with post-stroke limb spasticity.
Botulinum toxin injections are the primary choice for managing focal spasticity in stroke survivors, while neuromodulation shows significant…
Frontiers Apr 14, 2026
Plastic changes in brainstem reticular formation may be involved in spasticity onset across stroke and spinal cord injury
Neurology Sys. Review
Plastic changes in brainstem reticular formation may be involved in spasticity onset across stroke and spinal cord injury Could brainstem plastic changes trigger spasticity in stroke and spinal cord injury patients?
This systematic review examined pathophysiological similarities in spasticity among humans, primates, and rodents.
Spasticity after stroke or spinal cord injury may stem from plastic changes in the brainstem, though evidence remains limited and controvers…
Frontiers Apr 9, 2026

Questions about Spasticity

Do stroke and spinal cord injury share similar causes for spasticity?

Stroke and spinal cord injury share similar underlying causes for spasticity, primarily involving maladaptive changes in the central nervous system and plastic changes in the brainstem reticular formation.

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Are there plastic brain changes involved in the onset of spasticity?

Yes, plastic brain changes in the brainstem reticular formation are believed to contribute to the onset of spasticity after central nervous system injuries like stroke or spinal cord injury.

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How do neuromodulation and botulinum toxin injections help post-stroke spasticity?

Botulinum toxin injections relax tight muscles to improve movement, while neuromodulation techniques like magnetic stimulation adjust brain signals to reduce spasticity and promote recovery.

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What is the therapeutic potential of botulinum toxin for limb spasticity?

Botulinum toxin injections are a primary treatment for focal limb spasticity after stroke, reducing muscle tightness and preventing joint contractures while improving function.

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Does brain stimulation offer relief for post-stroke pain and spasticity?

Brain stimulation techniques like repetitive peripheral magnetic stimulation and transcranial magnetic stimulation show promise for reducing spasticity and easing post-stroke pain, though more large-scale trials are needed to confirm long-term benefits.

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Can repetitive peripheral magnetic stimulation help with stroke motor recovery?

Yes, repetitive peripheral magnetic stimulation (rPMS) can improve upper limb motor function, daily living, and spasticity after stroke, especially when combined with other therapies.

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See all 6 questions about Spasticity →