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Home › Conditions › Tourette Syndrome

Tourette Syndrome

Part of Movement Disorders

3 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Tourette Syndrome

28 trials tracked for Tourette Syndrome: 8 in phase 3 or 4 and 3 with published results. The most-cited published study has 192 citations.

28Trials tracked
8Phase 3 & 4
0Recruiting
3With published results
Phase distribution
Phase 4 4 Phase 3 4 Phase 2 10 Other / NA 10
  1. Phase 3 A Randomized, Placebo-controlled, Tourette Syndrome Study. Completed · 192 cited
  2. Phase 3 A Study to Test if TEV-50717 is Effective in Relieving Tics Associated With Tourette Syndrome (TS) Completed · 40 cited
  3. Phase 3 Alternatives for Reducing Tics in Tourette Syndrome (TS): A Study of TEV-50717 (Deutetrabenazine) for the Treatment of Tourette Syndrome in Children and Adolescents Completed · 39 cited
  4. Phase 4 Guanfacine in Children With Tic Disorders Completed
  5. Phase 4 Effects of Ondansetron in Obsessive-compulsive and Tic Disorders Completed
  6. Phase 4 Developing New Treatments for Tourette Syndrome: Therapeutic Trials With Modulators of Glutamatergic Neurotransmission Completed
Show 22 more trials
  1. Phase 4 Comparison of Keppra and Clonidine in the Treatment of Tics Completed
  2. Phase 3 An Open-label Study to Determine the Efficacy and Safety of Topiramate in the Treatment of Tourette Syndrome. Completed
  3. Phase 2 Efficacy of a Therapeutic Combination of Dronabinol and PEA for Tourette Syndrome Completed
  4. Phase 2 Open-Label Safety and Tolerability Study of NBI-98854 for the Treatment of Pediatric Subjects With Tourette Syndrome Completed
  5. Phase 2 Ecopipam Tablets to Study Tourette's Syndrome in Children and Adolescents Completed
  6. Phase 2 Safety and Efficacy Study of NBI-98854 in Children and Adolescents With Tourette Syndrome Completed
  7. Phase 2 Pramipexole Pilot Phase II Study in Children and Adolescents With Tourette Disorder According to DSM-IV Criteria Completed
  8. Phase 2 Safety and Tolerability Study of NBI-98854 for the Treatment of Subjects With Tourette Syndrome Completed
  9. Phase 2 Safety, Tolerability, Pharmacokinetic, and Efficacy Study of AZD5213 in Adolescents With Tourette's Disorder Completed
  10. Phase 2 Safety, Tolerability, and Efficacy of NBI-98854 for the Treatment of Pediatric Subjects With Tourette Syndrome Completed
  11. Phase 2 Transcranial Magnetic Stimulation (TMS) for Individuals With Tourette's Syndrome Completed
  12. Phase 2 Safety and Efficacy Study of NBI-98854 in Adults With Tourette Syndrome Completed
  13. N/A Tourette Syndrome Deep Brain Stimulation Completed
  14. N/A Median Nerve Stimulation Pilot Completed
  15. N/A Combined CBIT and rTMS to Improve Tourette's Syndrome Completed
  16. N/A Brain Stimulation for the Treatment of Tourette Syndrome Completed
  17. N/A Response Inhibition in Tourette Syndrome Completed
  18. N/A Proof of Concept Study of an Oral Orthotic to Reduce Tic Severity in Chronic Tic Disorder and Tourette Syndrome Completed
  19. N/A Transcranial Magnetic Stimulation to Augment Behavior Therapy for Tics Completed
  20. N/A Repetitive Transcranial Magnetic Stimulation to Reduce Tics Completed
  21. N/A Transcranial Magnetic Stimulation for Children With Tourette's Syndrome Completed
  22. N/A Open-label MNS for Tourette Syndrome Completed

Showing the 28 most-cited and recently-updated of 28 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Tourette syndrome involves multilevel dysfunction linking internal states to motor output via negative reinforcement
Psychiatry Sys. Review
Tourette syndrome involves multilevel dysfunction linking internal states to motor output via negative reinforcement A new model explains how Tourette syndrome tics start and stop
This narrative review explores the pathophysiology of Tourette syndrome in patients with the condition. The authors synthesize evidence sugg…
This review explains how Tourette syndrome tics begin with internal urges and end with temporary relief, offering a clearer picture for pati…
Frontiers May 31, 2026
Narrative review proposes connectomic-guided psychosurgery framework for treatment-refractory patients
Psychiatry Sys. Review
Narrative review proposes connectomic-guided psychosurgery framework for treatment-refractory patients Researchers report framework for psychosurgery in treatment-refractory cases
This narrative critical review synthesizes contemporary psychosurgery options for treatment-refractory psychiatric disorders.
A new framework proposes connectomic-guided psychosurgery for treatment-refractory OCD, depression, and related disorders, based on symptom …
Frontiers Apr 23, 2026
GWAS identifies six genetic loci associated with Tourette syndrome in European ancestry populations
Genetics & Precision Medicine
GWAS identifies six genetic loci associated with Tourette syndrome in European ancestry populations Study finds genetic links between Tourette Syndrome and other brain conditions in a large group
This genome-wide association study analyzed 13,247 cases and 536,217 controls of European ancestry to identify genetic risk factors for Tour…
Tourette Syndrome shares specific genetic links with ADHD and other brain conditions, pinpointing 20 genes tied to dopamine neurons and brai…
medRxiv Apr 14, 2026