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Home › Conditions › Upper respiratory tract infection

Upper respiratory tract infection

2 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Upper respiratory tract infection

5 trials tracked for Upper respiratory tract infection: 3 in phase 3 or 4 and 1 with published results. The most-cited published study has 2 citations.

5Trials tracked
3Phase 3 & 4
0Recruiting
1With published results
Phase distribution
Phase 4 2 Phase 3 1 Phase 2 1 Other / NA 1
  1. Phase 4 The Efficacy of the 2023-2024 Updated COVID-19 Vaccines Against COVID-19 Infection Completed · 2 cited
  2. Phase 4 Comparison of Efficacy and Tolerability of Two Cough Syrups in Cough Due to Cold in Children. Completed
  3. Phase 3 Evaluation of Efficacy and Safety of Tablets of Paracetamol, Dimethindene Maleate and Phenylephrine Hydrochloride in Reducing Symptoms of Common Cold and Flu Completed
  4. Phase 2 RI-001 in Immunosuppressed Respiratory Syncytial Virus (RSV) Infected Patients at Risk of Lower Tract RSV Illness Completed
  5. N/A Homeopathic Cold Medicine for Children Completed

Showing the 5 most-cited and recently-updated of 5 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

What the trials found For clinicians

Upper respiratory tract infection: what the trials found

Carbocisteine cough syrup has been shown to significantly reduce cough scores in patients with upper respiratory tract infections. Specifically, treatment resulted in a significant reduction in the Night Cough Score from the first night of treatment (p<0.01) and at the end of the study period (p<0.01). Additionally, a statistically significant decrease in Day Cough Scores was observed by the end of the study (p<0.05) 2.

Clinical data exists regarding the administration of a combination of paracetamol (500 mg), dimethindene maleate (1 mg), and phenylephrine hydrochloride (10 mg) for symptom management, with recorded daily averages for total symptoms reaching 169.2 and 225.3 3.

The Novavax COVID-19 vaccine (2023-2024 formula XBB containing) has been evaluated in a Phase 4 study involving 1,188 participants 1.

Recent results — preliminary, needs further review

  • RI-001 was evaluated in a Phase 2 trial (N=21), but results are not yet corroborated.
  • Hyland's Cold 'n Cough 4 Kids was assessed in a study of 50 participants, but results are not yet corroborated.

For the clinician treating this condition

  • Carbocisteine cough syrup is effective in reducing both day and night cough scores in patients with upper respiratory infections 2.
  • Combination therapy involving paracetamol, dimethindene maleate, and phenylephrine hydrochloride is utilized for managing the sum of symptoms 3.

AI synthesis of 3 cited trials, updated Aug 3, 2026. Informational only — not medical advice; trial data sourced from ClinicalTrials.gov. How we use AI.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Combined nasopharyngeal and oral suction reduces respiratory adverse events in children with upper respiratory infections
Pediatrics RCT
Combined nasopharyngeal and oral suction reduces respiratory adverse events in children with upper respiratory infections Combined Suctioning May Reduce Respiratory Issues for Children with Infections
Researchers evaluated whether adding nasopharyngeal suctioning to oral suctioning reduced perioperative respiratory adverse events in childr…
A new trial suggests that combined nasopharyngeal and oral suction can lower respiratory risks for children with upper tract infections duri…
Aug 3, 2026
Precision synbiotic reduces URTI incidence from 85.4% to 55.4% in toddlers
Nutrition & Obesity Medicine RCT
Precision synbiotic reduces URTI incidence from 85.4% to 55.4% in toddlers New synbiotic formula may cut common toddler infections and eczema
This multicenter randomized controlled trial of 390 healthy toddlers aged 1-3 years found that a precision synbiotic significantly reduced u…
A new combination of a specific sugar and healthy bacteria could significantly reduce respiratory infections, diarrhea, and skin issues in t…
Frontiers Jul 31, 2026