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Home › Conditions › Uremic pruritus

Uremic pruritus

0 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Uremic pruritus

11 trials tracked for Uremic pruritus: 9 in phase 3 or 4 and 7 with published results. The most-cited published study has 113 citations.

11Trials tracked
9Phase 3 & 4
0Recruiting
7With published results
Phase distribution
Phase 3 9 Phase 2 1 Other / NA 1
  1. Phase 3 A Study to Evaluate the Safety and Efficacy of CR845 in Hemodialysis Patients With Moderate-to-Severe Pruritus (KALM-1) Completed · 113 cited
  2. Phase 3 CR845-CLIN3103: A Global Study to Evaluate the Safety and Efficacy of CR845 in Hemodialysis Patients With Moderate-to-Severe Pruritus Completed · 113 cited
  3. Phase 3 Study of Nalbuphine HCl ER Tablets in Hemodialysis Patients With Uremic Pruritus Completed · 91 cited
  4. Phase 3 Study to Evaluate IV CR845 in Hemodialysis Patients With Moderate-to-Severe Pruritus Completed · 91 cited
  5. Phase 3 CR845-CLIN3105: A Study to Evaluate the Safety and Effectiveness of CR845 in Hemodialysis Patients With Moderate-to-Severe Pruritus Completed · 49 cited
  6. Phase 3 Extension Study to Evaluate IV CR845 in Hemodialysis Patients With Moderate-to-Severe Pruritus Completed · 49 cited
Show 5 more trials
  1. Phase 3 A Phase III Clinical Study of MR13A9 in Hemodialysis Patients With Pruritus. Completed · 15 cited
  2. Phase 3 Open Label Extension Study of Nalbuphine HCl ER in Hemodialysis Patients With Uremic Pruritus Completed
  3. Phase 3 Phase 3 Study of Difelikefalin in Haemodialysis Chinese Adult Subjects With Moderate-to-Severe Pruritus Completed
  4. Phase 2 A Clinical Study of MR13A9 in Hemodialysis Patients With Pruritus. Completed
  5. N/A The Effect of Phototherapy on Pruritus of Patients With Chronic Kidney Disease Completed

Showing the 11 most-cited and recently-updated of 11 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

What the trials found For clinicians

Uremic pruritus: what the trials found

CR845 0.5 mcg/kg demonstrated significant reductions in itch intensity and improvements in quality of life for patients with uremic pruritus. Specifically, a majority of patients achieved an improvement of ≥3 points on the Weekly Mean Daily 24-hour Worst Itching Intensity NRS at week 12 [1, 2]. Additionally, CR845 showed significant reductions in the mean NRS score at week 8 [-3.8; -2.8; -3.2; -1.9, p<0.001] and corresponding improvements in Total Skindex-10 scores [-18.7; -15.5; -15.1; -8.2, p<0.001] 4.

MR13A9 showed a statistically significant reduction in mean NRS scores at week 4 (-2.06; -1.09, p<0.001) 7, although results for MR13A9 at week 8 did not reach statistical significance (p=0.770) 10. Difelikefalin Injection also demonstrated a significant reduction in the Weekly Mean of the Daily 24-hour WI-NRS score at week 4 (-2.09; -1.27, p=0.0003), with varying percentages of patients achieving ≥3 or ≥4 point improvements 8.

Several Phase 3 trials evaluated nalbuphine HCl ER for uremic pruritus [3, 9], and other studies investigated CR845 [5, 6] without reporting specific outcome values in the provided data.

Recent results — preliminary, needs further review

  • Phototherapy (Narrow band UVB and long wave UVA) showed a reduction in Visual Analogue Scale (VAS) scores for pruritus (-3.38; -3.53, p<0.05), though this finding is not yet corroborated.

For the clinician treating this condition

  • CR845 0.5 mcg/kg is associated with significant reductions in itch intensity (NRS) and improvements in patient-reported quality of life (Skindex-10, 5-D Itch Scale) [1, 2, 4].
  • Difelikefalin Injection demonstrated statistically significant improvements in itching scores at week 4 8.
  • MR13A9 showed significant reduction in mean NRS scores at week 4, but did not reach statistical significance at the week 8 mark [7, 10].

AI synthesis of 4 cited trials, updated Aug 14, 2026. Informational only — not medical advice; trial data sourced from ClinicalTrials.gov. How we use AI.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
No published articles yet for this condition. Check back soon.