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Home › Conditions › Varicose Veins

Varicose Veins

1 published article · Updated continuously

Clinical Trial Landscape

Clinical Trials for Varicose Veins

14 trials tracked for Varicose Veins: 6 in phase 3 or 4 and 2 with published results. The most-cited published study has 28 citations.

14Trials tracked
6Phase 3 & 4
0Recruiting
2With published results
Phase distribution
Phase 4 3 Phase 3 3 Phase 2 2 Phase 1 1 Other / NA 5
  1. Phase 4 Study Protocol Comparing Polidocanol Versus Hypertonic Glucose for Treatment of Reticular Veins Completed · 28 cited
  2. Phase 4 Polidocanol Versus Glucose Treatment of Telangiectasia Trial Completed · 3 cited
  3. Phase 4 COMFORT: A Multicenter, Open-label, Randomized, Crossover Study Completed
  4. Phase 3 Randomized, Single Blind, Placebo Controlled, to Evaluate Efficacy and Safety of Polidocanol Injectable Foam for Treatment of Symptomatic, Visible Varicose Veins With SFJ Incompetence Completed
  5. Phase 3 Efficacy and Safety Study of Polidocanol Injectable Foam for the Treatment of Saphenofemoral Junction (SFJ) Incompetence Completed
  6. Phase 3 Polidocanol Endovenous Microfoam (PEM) Versus Vehicle for the Treatment of Saphenofemoral Junction (SFJ) Incompetence Completed
Show 8 more trials
  1. Phase 2 Safety Study of Varisolve® Procedure for Treatment of Varicose Veins in Patients With Right-to-left Cardiac Shunt Completed
  2. Phase 2 An Open-label, Single-dose Pilot Study to Evaluate Varisolve® (Polidocanol Endovenous Microfoam (PEM)) 0.125% [0.2%] for Varicose Veins Completed
  3. Phase 1 Pharmacokinetic Study of Polidocanol Endovenous Microfoam (PEM) Completed
  4. N/A Compression Therapy Following Endothermal Ablation Completed
  5. N/A REVITIVE for the Treatment of Patients With Venous Insufficiency Completed
  6. N/A DESIVI: Dosing of Electrical Stimulation in Venous Insufficiency Completed
  7. N/A Mechanochemical Ablation Compared to Cyanoacrylate Adhesive Completed
  8. N/A The Long-term Value of Preoperative Duplex Before Surgery for Varicose Veins Completed

Showing the 14 most-cited and recently-updated of 14 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

What the trials found For clinicians

Varicose Veins: what the trials found

Polidocanol injectable foam (PEM) has demonstrated significant improvements in patient-reported symptoms of varicose veins, with the VVSymQ score showing statistically significant reductions (p=0.0001) 4. Additionally, a specific concentration of polidocanol injectable foam (0.125%) showed highly significant improvements in both patient-reported symptoms (p<0.0001) and physician-rated appearance scores (IPR-V3; p<0.0001) at 8 weeks post-treatment 5.

Clinical evaluations of polidocanol injectable foam (PEM) also showed significant improvements in patient-assessed appearance (PA-V3, p=0.0001) and physician-reviewed photographic scores (IPR-V3, p=0.0001) 4. Varisolve (Polidocanol Endovenous Microfoam) was associated with absolute reductions in total VVSymQ scores at 8 weeks post-treatment 6.

Treatment with Polidocanol with Glucose showed a mean disappearance of reticular veins of 95.17% and 85.40% after two months, while maintaining low rates of skin hyperpigmentation (5.75% and 9.66%) 1.

Recent results — preliminary, needs further review

  • Polidocanol Endovenous Microfoam (0.125%) is currently undergoing further evaluation in Phase 2 trials 7.
  • Polidocanol (1%) Microfoam (Varisolve) is under investigation in Phase 2 studies 8.
  • Mechanochemical ablation was evaluated for pain scores during and after the procedure, with reported reductions from initial to end-of-procedure scores 10.
  • REVITIVE IX Neuromuscular Stimulation showed significant changes in Time Averaged Mean Velocity (TAMV) and limb swelling volume, though clinical symptoms did not reach statistical significance 12.

For the clinician treating this condition

  • Polidocanol injectable foam (PEM) is associated with statistically significant improvements in both patient-reported symptoms and physician-rated appearance scores [4, 5].
  • Polidocanol with Glucose demonstrated high efficacy in reticular vein disappearance with manageable rates of skin hyperpigmentation 1.
  • Varisolve (Polidocanol Endovenous Microfoam) showed significant absolute reductions in VVSymQ scores at the 8-week mark 6.

AI synthesis of 8 cited trials, updated Jun 29, 2026. Informational only — not medical advice; trial data sourced from ClinicalTrials.gov. How we use AI.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Large language models provide consistent informational quality but low verifiability for varicose veins information
Primary Care & Family Medicine Guideline
Large language models provide consistent informational quality but low verifiability for varicose veins information AI models provide similar quality information on varicose veins
This benchmarking study evaluated 100 responses from five large language models regarding varicose veins. While models achieved similar info…
Different AI tools give similar quality answers about varicose veins, but they all struggle to provide verifiable medical evidence.
Frontiers Jun 17, 2026