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Home › Conditions › xerostomia

Xerostomia

Part of Salivary Gland Diseases

0 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for xerostomia

20 trials tracked for xerostomia: 3 in phase 3 or 4 and 1 with published results. The most-cited published study has 51 citations.

20Trials tracked
3Phase 3 & 4
0Recruiting
1With published results
Phase distribution
Phase 4 1 Phase 3 2 Phase 2 4 Other / NA 13
  1. Phase 3 Acupuncture-Like Transcutaneous Electrical Nerve Stimulation (ALTENS) or Pilocarpine in Treating Early Dry Mouth in Patients Undergoing Radiation Therapy for Head and Neck Cancer Completed · 51 cited
  2. Phase 4 Effect of Korean Red Ginseng (KRG) on Dry Mouth Completed
  3. Phase 3 Drug-induced Xerostomia. Evaluation of Malic Acid 1%, Salivary Mucins and Buffering Capacity Completed
  4. Phase 2 Green Tea Lozenges for the Management of Dry Mouth Completed
  5. Phase 2 Exploratory Study for Dry Mouth in Patients With Sjögren's Syndrome Completed
  6. Phase 2 Salivary Gland Surgery Before Radiation Therapy in Preventing Radiation-Caused Xerostomia in Patients With Head and Neck Cancer Completed
Show 14 more trials
  1. Phase 2 Mesenchymal Stemcells for Radiation Induced Xerostomia Completed
  2. N/A SaliPen Human Factors Study for OTC Labeling Completed
  3. N/A Blinded Dry Mouth Spray Crossover Study Completed
  4. N/A Exploratory Study on Effect of Whitening Agent With Emulsion Gel in Xerostomic Population Completed
  5. N/A Clinical Evaluation of MucoPEG™ for Xerostomia Completed
  6. N/A Consumer Perception of an Experimental Mouthwash After a Single Use in Dry Mouth Subjects Completed
  7. N/A Evaluation of the Efficacy of 3M Dry Mouth Moisturizing Spray Completed
  8. N/A A Clinical Study to Evaluate the Efficacy of Three Dry Mouth Relief Products Versus Water Completed
  9. N/A Potential of an Experimental Mouthwash Formulation to Reduce Dry Mouth Symptoms Completed
  10. N/A Laser Therapy to Treat the Dry Mouth of Sjogren's Syndrome Completed
  11. N/A Effects of an External Oral Irrigation Device on Patients With Dry Mouth Completed
  12. N/A Trial of Parotid Sparing Whole Brain Radiation Completed
  13. N/A Clinical Evaluation of Oral Rinse for Xerostomia Completed
  14. N/A NeutraSal Treatment for Xerostomia in OSAS Patients Using CPAP Therapy Completed

Showing the 20 most-cited and recently-updated of 20 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

What the trials found For clinicians

Xerostomia: what the trials found

Korean Red Ginseng Powder Capsule has been shown to significantly improve subjective dry mouth symptoms as measured by a Visual Analogue Scale, while also increasing both stimulated and unstimulated salivary flow rates 1.

Biotene mouthwash was evaluated in multiple studies; one trial demonstrated a statistically significant improvement in relieving the discomfort of dry mouth within 120 minutes post-treatment 20. Another study included Biotene mouthwash as an established intervention, though specific outcome metrics were not detailed in that instance 18.

Pilocarpine was evaluated for xerostomia; however, it did not produce a statistically significant change in overall xerostomia burden or symptom burden at any measured interval ranging from 4 to 15 months 2.

Recent results — preliminary, needs further review

  • Mesenchymal stem cell (not yet corroborated) 4
  • Rebamipide (not yet corroborated) 5
  • MighTeaFlow (not yet corroborated) 6
  • Salivary gland transfer (not yet corroborated) 7
  • MucoPEG showed a significant reduction in Visual Analogue Scale scores for both mouth dryness and tongue dryness 8

For the clinician treating this condition

  • Korean Red Ginseng Powder Capsule is associated with improved subjective symptoms and increased salivary flow rates.
  • Biotene mouthwash has demonstrated rapid relief of dry mouth discomfort (within 2 hours).
  • Pilocarpine did not demonstrate a statistically significant reduction in xerostomia burden or symptom severity over a 15-month period.

AI synthesis of 9 cited trials, updated Jun 26, 2026. Informational only — not medical advice; trial data sourced from ClinicalTrials.gov. How we use AI.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
No published articles yet for this condition. Check back soon.