Sedative-hypnotic use associated with OR 1.29 for incident Alzheimer's Disease
Meta-analysis links sedative-hypnotic drug use to higher Alzheimer risk
This meta-analysis of observational cohort and nested case-control studies involving 721,354 adults without baseline dementia found that sed…
A large study suggests a link between the use of common sleep medications like benzodiazepines and an increased risk of developing Alzheimer…
Benzodiazepines increase delirium and sleep fragmentation risk while dexmedetomidine shows mixed evidence in pediatric ICU
Sedation Choices May Impact Brain Health in Critically Ill Children
This narrative review examines sedation practices and neurocognitive outcomes in critically ill infants and children. It suggests benzodiaze…
Choosing different sedative medications for children in intensive care may impact their sleep quality and long-term brain health.
Mood disorders and benzodiazepine use increase risk for new persistent opioid use in postsurgical adults
Mood Disorders and Anxiety Linked to Higher Risk of Opioid Use
This meta-analysis of retrospective cohort studies identifies that mood disorders, anxiety, Medicaid enrollment, and preoperative benzodiaze…
Patients with anxiety or mood disorders may face a higher risk of developing persistent opioid use after surgery.
Review of 2-AG and benzodiazepines for anxiety disorders highlights mechanistic gaps
New review questions how 2-AG might help anxiety disorders in humans
This narrative review synthesizes preclinical evidence on 2-arachidonoylglycerol and benzodiazepines for anxiety disorders. The authors note…
A new review suggests 2-AG could help anxiety, but lab tests used unrealistic doses and human proof is still missing.
Paracingulate sulcus prevalence reduced in patients with catatonia compared to controls
New Brain Scan Clue Points to Catatonia Risk
This hospital-based cohort study compared the paracingulate sulcus (PCS) in 109 patients with catatonia, 323 non-catatonic psychiatric patie…
A new study links specific brain shapes to catatonia, offering hope for better understanding.
Relaxation training and early benzodiazepines linked to respiratory recovery in adults with COPD, pneumonia, asthma, bronchiectasis, or interstitial lung disease
Could early sedatives be slowing down lung recovery for adults with breathing problems?
This retrospective observational study examined 389 consecutive adults (≥ 18 years) admitted with chronic obstructive pulmonary disease, pne…
Early sedatives given to adults with breathing problems may slow lung recovery, making it harder for patients to improve before leaving the …
Benzodiazepines, Dexmedetomidine, and Physical Restraints Associated with Next-Day Delirium in Critically Ill Children
Study finds link between certain medications, restraints, and delirium in critically ill children
A secondary analysis of a pilot RCT dataset in 1,006 critically ill children across seven PICUs found previous-day benzodiazepine and dexmed…
Higher doses of sedatives like midazolam and any use of physical restraints are linked to increased confusion in critically ill children the…