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Post-stroke spasticity

Part of Stroke

5 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for post-stroke spasticity

5 trials tracked for post-stroke spasticity: 5 in phase 3 or 4 and 2 with published results. The most-cited published study has 106 citations.

5Trials tracked
5Phase 3 & 4
0Recruiting
2With published results
Phase distribution
Phase 3 5
  1. Phase 3 Dysport® Adult Lower Limb Spasticity Follow-on Study Completed · 106 cited
  2. Phase 3 A Phase III Study to Evaluate the Efficacy and Safety of GSK1358820 in Subjects With Post-stroke Upper Limb Spasticity Completed · 17 cited
  3. Phase 3 Study of GSK1358820 In Patients With Post-Stroke Lower Limb Spasticity Completed
  4. Phase 3 A Multicenter, Open-label, Single Dose Study of the Safety and Efficacy of GSK1358820 (Botulinum Toxin Type A) in Chinese Subjects With Post-stroke Focal Upper Limb Spasticity Completed
  5. Phase 3 Study Of GSK1358820 In Patients With Post-Stroke Upper Limb Spasticity Completed

Showing the 5 most-cited and recently-updated of 5 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

What the trials found For clinicians

Post-stroke spasticity: what the trials found

Botulinum toxin type A has been shown to reduce muscle tone in various muscle groups following a stroke. In the gastrocnemius-soleus complex, treatment resulted in mean Modified Ashworth Scale (MAS) score reductions of -0.8 to -1.0 at week 4 1. Additionally, over 56% to 66% of patients achieved a 1 or 2 grade reduction in MAS scores for the gastrocnemius-soleus complex 1, and between 61% and 72% achieved similar reductions in the soleus muscle.

Specific upper extremity improvements were observed with Botulinum toxin type A. Studies demonstrated significant reductions in wrist flexor muscle tone (MAS) at weeks 6 and 12 (p<0.0001) 3. Furthermore, treatment with GSK1358820 resulted in MAS score reductions across the elbow, wrist, finger, and thumb flexors by week 12 2, with mean changes ranging from -0.59 to -1.12 2.

Clinical outcomes associated with Botulinum toxin interventions include improvements in functional scales. Patients reported improved Global Assessment Scale (GAS) scores at weeks 6 and 12 3. Treatment with GSK1358820 also demonstrated mean reductions in Disability Assessment Scale (DAS) scores for the primary measure [-0.49 to -0.82] 4, as well as improvements in Physician's Rating Score (PRS) and Clinical Global Impression (CGI) of functional disability 5.

For the clinician treating this condition

  • Botulinum toxin type A is effective in reducing muscle tone in the lower extremities, specifically the gastrocnemius-soleus complex, with a majority of patients achieving at least a 1-grade reduction on the MAS 1.
  • Upper extremity interventions with Botulinum toxin (including GSK1358820) consistently reduce MAS scores in wrist, finger, and elbow flexors by week 12 [2, 4].
  • Botulinum toxin administration is associated with measurable improvements in functional outcomes, including GAS, DAS, and physician-rated clinical impressions of disability [3, 4, 5].

AI synthesis of 5 cited trials, updated Jun 24, 2026. Informational only — not medical advice; trial data sourced from ClinicalTrials.gov. How we use AI.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.

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Questions about post-stroke spasticity

Can muscle energy techniques help manage my post-stroke spasticity?

Muscle energy techniques may help reduce muscle tone, improve range of motion, and support function in post-stroke spasticity, but the evidence is early and comes mainly from small, low-quality studies [5][9].

Full answer →
Is acupuncture an effective treatment for managing post-stroke spasticity?

Acupuncture has shown good therapeutic potential for managing post-stroke spasticity, with various types of acupuncture being studied for their effectiveness.

Full answer →