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Home › Medications › buprenorphine

buprenorphine

9 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials of buprenorphine

45 trials tracked of buprenorphine: 25 in phase 3 or 4 and 4 with published results. The most-cited published study has 39 citations.

45Trials tracked
25Phase 3 & 4
0Recruiting
4With published results
Phase distribution
Phase 4 7 Phase 3 18 Phase 2 15 Phase 1 2 Other / NA 3
  1. Phase 3 Fetal and Infant Effects of Maternal Buprenorphine Treatment Completed · 39 cited
  2. Phase 4 Compare the Efficacy and Safety of Norspan to Tramadol/Acetaminophen With Prolonged Postoperative Pain (PASSION) Completed · 15 cited
  3. Phase 3 Evaluating Naltrexone for Use in Conjunction With Buprenorphine in Adults With Opioid Use Disorder Transitioning From Buprenorphine Maintenance Prior to First Dose of VIVITROL Completed · 8 cited
  4. Phase 3 Improving Treatment Outcomes for Prescription Opioid Dependence Completed · 1 cited
  5. Phase 4 Extended Release Naltrexone for Opioid-Dependent Youth Completed
  6. Phase 4 An Interventional Study to Assess the Efficacy and Safety of Buprenorphine in Korean Patients With Spinal Disorders Completed
Show 39 more trials
  1. Phase 4 Buprenorphine in the Treatment of Osteoarthritis (OA) in the Elderly Completed
  2. Phase 4 Relapse Prevention to Reduce HIV Among Women Prisoners Completed
  3. Phase 4 Preference for Subutex® (Buprenorphine) Versus Suboxone® (Buprenorphine/Naloxone) in Opioid Dependent Patients on Subutex® (Study P05094)(COMPLETED) Completed
  4. Phase 4 RCT Comparing the Analgesic Efficacy of 4 Therapeutic Strategies Based on 4 Different Major Opioids (Fentanyl, Oxycodone, Buprenorphine vs Morphine) in Cancer Patients With Moderate/Severe Pain, at the Moment of Starting 3rd Step of WHO Analgesic Ladder. Completed
  5. Phase 3 Buprenorphine for Treatment Resistant Depression Completed
  6. Phase 3 Study of Buprenorphine Sublingual Spray for the Treatment of Moderate to Severe Pain Completed
  7. Phase 3 Buprenorphine Group Medical Visits in Primary Care Completed
  8. Phase 3 Buprenorphine (CAM2038) in Subjects With a Recent History of Moderate to Severe Chronic Low Back Pain Completed
  9. Phase 3 A Strategy to Improve Success of Treatment Discontinuation in Buprenorphine Responders Completed
  10. Phase 3 Buprenorphine Treatment for Opioid Dependence Completed
  11. Phase 3 Opiate Suicide Study in Patients With Major Depression Completed
  12. Phase 3 Efficacy Study to Evaluate Buprenorphine HCl Buccal Film in Opioid-Experienced Subjects Completed
  13. Phase 3 Efficacy and Safety Study of Buprenorphine HCl Buccal Film in Subjects With Low Back Pain Completed
  14. Phase 3 RCT Comparing Methadone and Buprenorphine in Pregnant Women Completed
  15. Phase 3 Buprenorphine Maintenance Treatment of Opioid Dependence in Primary Care: A Randomized Clinical Trial Completed
  16. Phase 3 Efficacy Study to Evaluate Buprenorphine HCl Buccal Film in Opioid-Naive Subjects Completed
  17. Phase 3 Efficacy of BNX Sublingual Tablets Versus BNX Sublingual Film for Treatment of Opioid-Dependent Adults Completed
  18. Phase 3 Study to Assess Efficacy and Safety of BNX Sublingual Tablets for the Induction of Treatment of Opioid Dependence Completed
  19. Phase 3 Buprenorphine Transdermal System (BTDS) in Subjects w/Mod-sev Osteoarthritis (OA) Chronic Pain of Knee Completed
  20. Phase 2 Buprenorphine for Late-Life Treatment Resistant Depression Completed
  21. Phase 2 Clinical Trial of Integrated Treatment for Pain and Opioid Dependence Completed
  22. Phase 2 Buprenorphine Pharmacometric Open Label Research Study of Drug Exposure Completed
  23. Phase 2 Study of Buprenorphine HCl Buccal Film in the Treatment of Dental Pain Completed
  24. Phase 2 Effects of Gabapentin Versus Placebo on Buprenorphine Detoxification of Opioid-dependent Individuals Completed
  25. Phase 2 Incomplete Response in Late-Life Depression: Getting to Remission With Buprenorphine Completed
  26. Phase 2 Multiple Dose Study of Blockade of Opioid Effects by Injections of Buprenorphine in Participants With Opioid Disorder Completed
  27. Phase 2 A Within Subject Comparison of Opioid Withdrawal in Opioid Dependent Individuals Completed
  28. Phase 2 Onsite Buprenorphine Treatment at Syringe Exchange Programs Completed
  29. Phase 2 HOPE Consortium Trial to Reduce Pain and Opioid Use in Hemodialysis Completed
  30. Phase 2 Transdermal Buprenorphine for the Treatment of Radiation-Induced Mucositis Pain in Head and Neck Cancer Patients Completed
  31. Phase 2 Evaluation of the Tolerability of Switching Subjects on Chronic ATC Opioid Therapy to Buprenorphine HCl Buccal Film Completed
  32. Phase 2 Assessing the Safety of Buprenorphine in People With Sickle Cell Disease Completed
  33. Phase 2 Buprenorphine's Dose Response Curve Completed
  34. Phase 2 Buprenorphine Used With Treatment Resistant Depression in Older Adults Completed
  35. Phase 1 Buprenorphine 8 mg Sublingual Tablets Under Fasting Conditions Completed
  36. Phase 1 Prolonged Popliteal Fossa Nerve Blockade (Prolonged Pop) Completed
  37. N/A Observational Study of Misuse of High Dose Buprenorphine (Subutex® or Generic) in Opiate-Addicted Patients in France (Study P05186AM1)(COMPLETED) Completed
  38. N/A Buprenorphine Disposition and Cyclosporine Completed
  39. N/A Pharmacokinetic Interactions Between Buprenorphine and Kaletra (Lopinavir/Ritonavir) Completed

Showing the 45 most-cited and recently-updated of 45 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Collaborative care improves depression severity in low-complexity patients with OUD and depression
Anesthesiology & Pain Medicine RCT
Collaborative care improves depression severity in low-complexity patients with OUD and depression Collaborative care helps some patients with opioid use and depression
This secondary analysis of a randomized clinical trial involving 797 adults with OUD, depression, and/or PTSD found that collaborative care …
Collaborative care may improve depression symptoms for some patients with opioid use disorder, depending on the complexity of their mental h…
Oct 5, 2026
Proposed network meta-analysis aims to establish evidence hierarchy for non-pharmacological opioid use disorder interventions
Primary Care & Family Medicine Meta-analysis
Proposed network meta-analysis aims to establish evidence hierarchy for non-pharmacological opioid use disorder interventions Comparing Non-Pharmacological Treatments for People with Opioid Use Disorder
This is a protocol for a systematic review and network meta-analysis regarding non-pharmacological interventions for opioid use disorder. Th…
Doctors are planning a large study to see if non-drug therapies can work as well as methadone or buprenorphine for patients.
Frontiers Sep 16, 2026
Methadone shows significantly higher treatment retention than buprenorphine-naloxone in patients with Opioid Use Disorder
Anesthesiology & Pain Medicine Meta-analysis
Methadone shows significantly higher treatment retention than buprenorphine-naloxone in patients with Opioid Use Disorder Methadone beats buprenorphine for opioid treatment retention
This meta-analysis of 7 randomized controlled trials involving 3622 patients found that methadone is associated with significantly higher tr…
Methadone keeps more people in opioid treatment than buprenorphine-naloxone, but the combo drug has fewer serious side effects.
Jul 7, 2026
Opioid Wizard tool increases primary care clinician confidence in screening, diagnosing, and referring patients for OUD
Anesthesiology & Pain Medicine RCT
Opioid Wizard tool increases primary care clinician confidence in screening, diagnosing, and referring patients for OUD Digital Tool Improves Clinician Confidence in Managing Opioid Use Disorder
This secondary analysis of an RCT evaluates the Opioid Wizard clinical decision support tool's impact on primary care clinicians managing op…
A new digital decision support tool helps primary care doctors feel more confident when screening and diagnosing patients with opioid use di…
Jul 6, 2026
High-dose buprenorphine induction protocol for Opioid Use Disorder in emergency department settings
Anesthesiology & Pain Medicine RCT
High-dose buprenorphine induction protocol for Opioid Use Disorder in emergency department settings New plan to test high-dose buprenorphine for opioid use disorder
This randomized clinical trial protocol describes a plan to evaluate high-dose buprenorphine induction for patients with moderate-to-severe …
A new clinical trial plans to see if higher doses of buprenorphine can help more people with opioid use disorder start treatment in the emer…
Jun 9, 2026
Meta-analysis shows methadone exposure linked to higher NAS incidence and treatment needs versus buprenorphine in pregnant women
Anesthesiology & Pain Medicine Meta-analysis
Meta-analysis shows methadone exposure linked to higher NAS incidence and treatment needs versus buprenorphine in pregnant women Buprenorphine-based therapies reduce neonatal abstinence syndrome risk compared to methadone in pregnant women
This systematic review and meta-analysis evaluated buprenorphine-based therapies and methadone in pregnant opioid-dependent women.
A large review of 5,524 pregnant women found babies exposed to buprenorphine had lower rates of withdrawal symptoms and needed less medicati…
May 1, 2026
Combination buprenorphine and psychotherapy linked to highest remission rates in opioid dependence patients
Psychiatry Cohort
Combination buprenorphine and psychotherapy linked to highest remission rates in opioid dependence patients Combining buprenorphine and therapy boosts remission rates for opioid dependence
This retrospective cohort study analyzed 18,047 adults aged 18–45 with opioid dependence across 112 U.S.
In a large study, pairing buprenorphine with psychotherapy showed the strongest link to remission from opioid use disorder compared to no tr…
Frontiers Apr 28, 2026
Lifetime opioid overdose reported by 55% of pregnant individuals with OUD in buprenorphine treatment study
Anesthesiology & Pain Medicine RCT
Lifetime opioid overdose reported by 55% of pregnant individuals with OUD in buprenorphine treatment study What puts pregnant women with opioid addiction at highest risk for overdose?
A descriptive analysis of baseline data from a multisite RCT of 140 pregnant individuals with OUD receiving buprenorphine found 55% reported…
Pregnant women in opioid treatment face high overdose risk if they have used heroin, experienced trauma, or rely on others for money.
Apr 3, 2026
Telemedicine-Assisted Buprenorphine Induction Non-Inferior to Standard Care for OUD Retention
Anesthesiology & Pain Medicine RCT
Telemedicine-Assisted Buprenorphine Induction Non-Inferior to Standard Care for OUD Retention Can starting addiction treatment by video work as well as in-person visits?
A randomized controlled non-inferiority trial in 138 adults with opioid use disorder in India found telemedicine-assisted buprenorphine indu…
Patients starting opioid addiction treatment via video calls stay in care just as well as those with in-person visits during the first week.
Apr 2, 2026