Necroptosis emerges as pathogenic hub in asthma, linking type 2 inflammation and steroid resistance
Necroptosis may drive severe inflammation in asthma cases
This systematic review posits necroptosis as an active pathogenic hub in asthma, driving type 2 inflammation, a neutrophilic steroid-refract…
New research identifies necroptosis as a potential driver of steroid-resistant inflammation and airway remodeling in patients with asthma.
Radiotherapy with re-irradiation achieves long-term remission in orbital Rosai-Dorfman disease
Radiotherapy Shows Promise for Orbital Rosai-Dorfman Disease Treatment
This case report describes a 58-year-old man with orbital Rosai-Dorfman disease who achieved complete remission for five years after initial…
A patient with orbital Rosai-Dorfman disease saw significant improvement in vision and remission after undergoing targeted radiation therapy…
Nemolizumab Q4W improves IGA success maintenance by 11.8% over withdrawal in atopic dermatitis
Trial shows nemolizumab maintains skin results for atopic dermatitis
This Phase 3 randomized controlled trial evaluated nemolizumab in 507 adolescents and adults with moderate-to-severe atopic dermatitis who w…
A new trial found that nemolizumab helps maintain clear skin and reduce itching for adults and teens with moderate to severe atopic dermatit…
Steroid avoidance may reduce death and diabetes after kidney transplant but raises rejection risk
Steroid avoidance after kidney transplant may reduce death and diabetes
This systematic review of 53 studies (8317 participants) found that steroid avoidance may reduce all-cause death at 1-5 years and post-trans…
Skipping steroids after a kidney transplant might lower the risk of death and diabetes, but could raise the chance of rejection.
Adjunctive corticosteroids may modestly reduce hospital stay for bacterial facial infections but evidence certainty is low
Adding steroids to facial infection treatment may shorten hospital stays by about one and a half days
This systematic review and meta-analysis evaluated adjunctive corticosteroid therapy versus standard treatment alone in patients with bacter…
A large review found that adding steroids to standard care for facial infections might shorten hospital stays, but the evidence is not yet s…
Immunomodulatory therapies showed no mortality benefit or neurological harm in 2605 adults after cardiac arrest
New drug review shows no benefit for heart attack survivors
This systematic review and meta-analysis evaluated immunomodulatory therapeutics in adults following in- and out-of-hospital cardiac arrest.…
A large review of immune drugs found no clear benefit for heart attack survivors and did not lower death rates within 30 days.
Systemic corticosteroid therapy significantly decreased length of hospital stay and fever duration in children with community-acquired pneumonia
Shorter hospital stays and fever for kids with pneumonia using steroids
This systematic review and meta-analysis evaluated systemic corticosteroid therapy versus controls in children with community-acquired pneum…
A large review found that adding steroids to standard antibiotics helped children with pneumonia leave the hospital faster and get over thei…
Kounis syndrome shows male predominance 75 percent and 4 percent mortality in systematic review
Most patients with Kounis syndrome recover well, though some face serious risks
This systematic review and meta-analysis of 71 cases of Kounis syndrome synthesized demographic patterns, clinical features, and outcomes. T…
A review of 71 cases shows most people with Kounis syndrome recover, but some face heart attacks or death.
Case report details treatment of ANCA-associated vasculitis with Evans syndrome and cerebral infarction in a 72-year-old woman
Treatment stabilized some symptoms but not others in a single patient case
This case report describes a 72-year-old female with ANCA-associated vasculitis, Evans syndrome, and cerebral infarction treated with cortic…
A 72-year-old woman with complex blood vessel disease saw some health markers improve while others remained poor after specific treatments.
Fecal Microbial Transplantation Shows Promise for Treating Gastrointestinal Acute Graft-Versus-Host Disease in Patients
Fecal transplant shows promise for gut graft-versus-host disease
A meta-analysis of 262 patients found that fecal microbial transplantation significantly improved complete response rates for gastrointestin…
A review of 262 patients found fecal transplants may improve gut graft-versus-host disease response rates compared to standard drugs.
Marburg MS case shows treatment challenges and fatal outcome
A Rare MS Variant Defied Treatment Until This Switch
A 46-year-old woman with aggressive Marburg MS faced treatment-limiting toxicity and died despite multiple therapies, highlighting urgent ca…
A woman with a rare, aggressive form of multiple sclerosis tried many treatments without success, and doctors tried a new approach too late.
Narrative review suggests suprachoroidal injections may improve vision and reduce edema in diabetic macular edema
New eye injection method reduces shots and protects vision for diabetics
This narrative review examines suprachoroidal space injections versus conventional intravitreal therapies for diabetic macular edema. The au…
A new injection technique for diabetic eye disease could spare patients from frequent shots and lower the risk of cataracts while improving …