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Home › Conditions › adhesive capsulitis

Adhesive capsulitis

2 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for adhesive capsulitis

7 trials tracked for adhesive capsulitis: 2 in phase 3 or 4 and 1 with published results. The most-cited published study has 406 citations.

7Trials tracked
2Phase 3 & 4
0Recruiting
1With published results
Phase distribution
Phase 4 2 Phase 2 3 Other / NA 2
  1. Phase 4 Intra-articular Doxycycline: A Novel Treatment of Adhesive Capsulitis Completed · 406 cited
  2. Phase 4 A Study to Determine the Safety and Effectiveness of a Connective Tissue Allograft (ActiveMatrix) Verses Standard of Care in Adhesive Capsulitis of the Shoulder Completed
  3. Phase 2 AA4500 for the Treatment of Adhesive Capsulitis of the Shoulder Completed
  4. Phase 2 Clinical Study for the Treatment of Adhesive Capsulitis of the Shoulder Completed
  5. Phase 2 Safety and Efficacy of EN3835 in Participants With Frozen Shoulder Completed
  6. N/A Should the Joint Capsule of the Painful Stiff Shoulder be Ruptured During Intra-articular Hydraulic Distension? Completed
Show 1 more trials
  1. N/A Percutaneous Interruption of the Coracohumeral Ligament for the Treatment of Frozen Shoulder Completed

Showing the 7 most-cited and recently-updated of 7 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

What the trials found Updated — new results For clinicians

Adhesive capsulitis: what the trials found

Corticosteroid administration for adhesive capsulitis has been shown to result in changes to the American Shoulder and Elbow Surgeons (ASES) Score, with reported values of 34.1 and 28.3 in one cohort, and 35.3 and 40.9 in another 1.

Methylprednisolone Injectable Product has been utilized as an intervention for the condition 2.

Recent results — preliminary, needs further review

  • EN3835 showed no statistically significant difference in the Adapted ASES Composite Score at Day 95 (p=0.659) 3.
  • AA4500 0.29 mg/1 mL resulted in varying changes from baseline to Day 92 in the ASES Composite Score, ranging from 9.9 to 41.6 4.
  • Collagenase Clostridium Histolyticum was evaluated as an intervention 5.
  • Local anesthetic and TENEX were compared for pain intensity; the local anesthetic group showed a change of 8, while the TENEX group showed a change of 3 6.
  • Capsule-Preserving Intra-articular Hydraulic Distension was investigated as a treatment modality 7.

For the clinician treating this condition

  • Corticosteroid injections are associated with measurable changes in ASES scores for patients with adhesive capsulitis 1.
  • Methylprednisolone is an established injectable option for management 2.

AI synthesis of 7 cited trials, updated Jun 29, 2026. Informational only — not medical advice; trial data sourced from ClinicalTrials.gov. How we use AI.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Combined physical therapy and intra-articular corticosteroid injections improve range of motion in adhesive capsulitis
Physical Medicine & Rehab Meta-analysis
Combined physical therapy and intra-articular corticosteroid injections improve range of motion in adhesive capsulitis Combining physical therapy and steroid injections improves frozen shoulder mobility
This meta-analysis of 198 patients with adhesive capsulitis found that combining physical therapy with intra-articular corticosteroid inject…
Adding corticosteroid injections to physical therapy helps patients with frozen shoulder regain more movement and function in the short term…
Jun 25, 2026
Suprascapular Nerve Block Added to Steroid Injection Shows Early Pain Benefit in Adhesive Capsulitis
Anesthesiology & Pain Medicine RCT
Suprascapular Nerve Block Added to Steroid Injection Shows Early Pain Benefit in Adhesive Capsulitis Does adding a nerve block to steroid shots help frozen shoulder patients feel better faster?
A randomized trial in 96 patients with adhesive capsulitis compared intra-articular steroid (IAS) injection alone to IAS plus suprascapular …
Adding a nerve block to steroid shots gives frozen shoulder patients quick pain relief, but it doesn't improve long-term shoulder function c…
Apr 8, 2026