Mode
Home
Research
Clinical Trials Drug Pipeline Weekly Digests
Reference
Conditions Medications
Community
Questions
Text Size
Log in / Sign up
Home › Medications › fentanyl

fentanyl

17 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials of fentanyl

74 trials tracked of fentanyl: 45 in phase 3 or 4 and 10 with published results. The most-cited published study has 116 citations.

74Trials tracked
45Phase 3 & 4
0Recruiting
10With published results
Phase distribution
Phase 4 31 Phase 3 14 Phase 2 12 Phase 1 4 Other / NA 13
  1. Phase 3 Pain Reduction With Intranasal Medications for Extremity Injuries Completed · 116 cited
  2. Phase 4 Single Injection Adductor Canal Block vs Catheter for Total Knee Arthroplasty Completed · 78 cited
  3. Phase 4 The Platelet Aggregation After tiCagrelor Inhibition and FentanYl Trial (PACIFY) Completed · 67 cited
  4. Phase 4 Comparison of Meperidine and Fentanyl on Pain Scale and QOL in Brachytherapy Completed · 43 cited
  5. Phase 4 Influence of Dexmedetomidine and Lidocaine on Opioid Consumption in Laparoscopic Intestine Resection Completed · 30 cited
  6. Phase 4 Chloroprocaine Spinal Anesthesia for Cervical Cerclage (CP Spinal) Completed · 21 cited
Show 44 more trials
  1. Phase 4 Remifentanil and Glycemic Response in Cardiac Surgery Completed · 19 cited
  2. Phase 4 Determining the Prognostic Value of Continuous Intrathecal Infusion Completed · 15 cited
  3. Phase 4 Ketamine Versus Fentanyl for Surgical Abortions Completed · 9 cited
  4. Phase 4 Designing Optimal Prevention and Management of Postoperative Nausea and Emesis for Patients Undergoing Laparoscopic Sleeve Gastrectomy Completed · 2 cited
  5. Phase 4 Intranasal Fentanyl for Initial Treatment of a Vaso-occlusive Crisis Completed
  6. Phase 4 Safety Study of Analgesia After Craniotomy Surgery With End Tidal (ET) Carbon Dioxide (CO2) Monitoring Completed
  7. Phase 4 Open Label Crossover Study Pharmacokinetics (PK) Study in Healthy Volunteers Receiving Various Forms of Fentanyl Completed
  8. Phase 4 Comparison of Epidural Fentanyl and Clonidine for Breakthrough Pain Completed
  9. Phase 4 Comparison of PIEB vs CEI for Labor Analgesia Completed
  10. Phase 4 A Non-inferiority Trial on Pain Relief During Oocyte Retrieval Completed
  11. Phase 4 Labetalol and Esmolol: Vital Signs and Post Operative Pain Management Completed
  12. Phase 4 Study of Sedative Medications in Patients With Severe Infection and Respiratory Failure Completed
  13. Phase 4 Programmed Intermittent Bolus Dosing Versus Continuous Epidural Infusion for Epidural Analgesia in Abdominal Surgery. Completed
  14. Phase 4 Effect of Dexmedetomidine on Postoperative Glucose and Insulin Levels. Completed
  15. Phase 4 Optimizing Outpatient Anesthesia (OSPREy-Outpatient Surgery Pain Relief Enhancement) Completed
  16. Phase 4 Intranasal Fentanyl as an Analgesic for Cystoscopic Procedures Completed
  17. Phase 4 Dexmedetomidine vs Fentanyl for BMT Completed
  18. Phase 4 The Effect of Choice of Intraoperative Opioid on Postoperative Pain Completed
  19. Phase 4 An Efficacy and Safety Study of Fentanyl Transdermal Patch in Filipino Participants With Osteoarthritis and Chronic Low Back Pain Completed
  20. Phase 4 Efficacy of Multimodal Peri- and Intraarticular Drug Injections in Total Knee Arthroplasty Completed
  21. Phase 4 Airway Responses During Desflurane Anesthesia Via a Laryngeal Mask Airway: Effects of Fentanyl Pretreatment Completed
  22. Phase 4 Dexmedetomidine for Immediate Perioperative Analgesia in Pediatric Patients Undergoing Tonsillectomy Completed
  23. Phase 4 RCT Comparing the Analgesic Efficacy of 4 Therapeutic Strategies Based on 4 Different Major Opioids (Fentanyl, Oxycodone, Buprenorphine vs Morphine) in Cancer Patients With Moderate/Severe Pain, at the Moment of Starting 3rd Step of WHO Analgesic Ladder. Completed
  24. Phase 4 Open-Label, Safety Study Evaluating the Use of Dexmedetomidine in Pediatric Subjects Undergoing Procedure-Type Sedation Completed
  25. Phase 4 Effects of General Anesthesia and Spinal-Morphine Anesthesia on Recovery and Comfort After Benign Abdominal Hysterectomy Completed
  26. Phase 4 Effect of Fentanyl on Coughing and Recovery After Anesthesia With an LMA Laryngeal Mask Airway)for Airway Management Completed
  27. Phase 3 Decrease Emergence Agitation and Provide Pain Relief for Children Undergoing Tonsillectomy & Adenoidectomy Completed
  28. Phase 3 Safety and Efficacy Study of Fentanyl Buccal Tablet Use in the Emergency Department for Isolated Extremity Injury Completed
  29. Phase 3 Safety and Clinical Utility Study of SSEC Fentanyl 40 mcg for Acute Post-op Pain Management in Pediatric Participants Completed
  30. Phase 3 Gabapentin Compared to Standard of Care in Preventing Mucositis in Patients With Stage III-IV Head and Neck Cancer Undergoing Primary or Adjuvant Chemoradiation Therapy Completed
  31. Phase 3 Dexmedetomidine to Treat Bariatric Surgery-associated Pain Completed
  32. Phase 3 Open-Label, Safety, and Efficacy Study of Dexmedetomidine in Preterm Subjects Ages ≥28 Weeks to <36 Weeks Gestational Age Completed
  33. Phase 3 Study Evaluating Safety and Efficacy of Dexmedetomidine (DEX) in Intubated and Mechanically Ventilated Pediatric Intensive Care Unit (PICU) Subjects Completed
  34. Phase 3 An Efficacy and Safety Study of Fentanyl (JNS020QD) in Participants With Cancer Pain Completed
  35. Phase 3 An Efficacy and Safety Study of Fentanyl in Participants With Chronic Pain Completed
  36. Phase 3 Dexmedetomidine Versus Fentanyl Following Pressure Equalization Tube Placement Completed
  37. Phase 3 Evaluate the Use of Paravertebral Block in Reconstructive Breast Surgery Completed
  38. Phase 3 A Confirmatory Study of Fentanyl in Participants With Osteoarthritis or Low Back Pain Completed
  39. Phase 3 A Confirmatory Study of Fentanyl in Participants With Post-herpetic Neuralgia, Complex Regional Pain Syndrome or Postoperative Pain Syndrome Completed
  40. Phase 2 Fentanyl Administered Intraorally for Rapid Treatment of Orthopedic Pain Completed
  41. Phase 2 Evaluation of DEX-IN During Outpatient Procedures Completed
  42. Phase 2 Fentanyl Sublingual Spray for the Treatment of Moderate to Severe Post-Operative Pain Completed
  43. Phase 2 IN Sub-Dissociative Ketamine vs IN Fentanyl Completed
  44. Phase 2 Analgesics in the Pre-hospital Setting: Implications on Hemorrhage Tolerance - Fentanyl Completed

Showing the 50 most-cited and recently-updated of 74 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Systematic Review Analyzes Pharmacometric Modeling of Opioids and Fentanyl in Pregnancy
Drug Pipeline Meta-analysis
Systematic Review Analyzes Pharmacometric Modeling of Opioids and Fentanyl in Pregnancy Opioid Dosing in Pregnancy May Need a Rethink
This systematic review evaluates pharmacometric modeling approaches, including population pharmacokinetic and physiologically based pharmaco…
Pregnancy speeds up how the body processes pain meds, meaning standard doses may leave moms in pain or risk baby safety.
Frontiers Apr 20, 2026
Meta-analysis shows dexmedetomidine lowers mean arterial pressure compared to midazolam-fentanyl in surgical patients
Anesthesiology & Pain Medicine Meta-analysis
Meta-analysis shows dexmedetomidine lowers mean arterial pressure compared to midazolam-fentanyl in surgical patients A Calmer Sedative May Make Surgery Safer for Patients
This systematic review and meta-analysis evaluated 259 surgical patients receiving either dexmedetomidine or midazolam-fentanyl during intra…
A newer sedative keeps patients calmer with steadier vitals and fewer breathing problems than the older standard combination during surgery.
Frontiers Apr 15, 2026
Retrospective cross-sectional study characterizes arachnoiditis patient presentation and treatment responses in 1105 participants
Neurology
Retrospective cross-sectional study characterizes arachnoiditis patient presentation and treatment responses in 1105 participants Back Pain That Won't Go Away
This retrospective cross-sectional study characterized clinical presentation, comorbidities, and treatments in 1105 participants with physic…
A massive online community of chronic pain patients helped researchers finally map the symptoms and treatments for the often missed conditio…
medRxiv Apr 15, 2026
Alfentanil-remimazolam shortens emergence time versus fentanyl-remimazolam in first-trimester abortion anesthesia
Rheumatology RCT
Alfentanil-remimazolam shortens emergence time versus fentanyl-remimazolam in first-trimester abortion anesthesia A Gentler Anesthesia Lets You Wake Up Faster After Surgery
A randomized trial in 120 patients undergoing first-trimester surgical abortion found that alfentanil-remimazolam led to shorter emergence a…
For common outpatient surgeries, a tweak in anesthesia drugs could mean a smoother, faster wake-up with fewer involuntary movements.
Frontiers Apr 12, 2026
Outpatient IV sedation for dental care in special needs patients shows 3.3% minor complication rate
Dermatology Cohort
Outpatient IV sedation for dental care in special needs patients shows 3.3% minor complication rate Study describes use of IV sedation for dental care in patients with special needs
A retrospective cohort study of 212 special health care needs patients (mean age 11.1 years) undergoing outpatient IV sedation for dental pr…
Over 2,200 dental procedures were safely performed on children with autism and Down syndrome using IV sedation at a Venezuelan clinic, with …
Frontiers Apr 8, 2026