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Home › Medications › hydroxychloroquine

hydroxychloroquine

8 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials of hydroxychloroquine

37 trials tracked of hydroxychloroquine: 15 in phase 3 or 4 and 11 with published results. The most-cited published study has 1406 citations.

37Trials tracked
15Phase 3 & 4
0Recruiting
11With published results
Phase distribution
Phase 4 5 Phase 3 10 Phase 2 20 Phase 1 1 Other / NA 1
  1. Phase 3 Post-exposure Prophylaxis / Preemptive Therapy for SARS-Coronavirus-2 Completed · 1,406 cited
  2. Phase 3 Outcomes Related to COVID-19 Treated With Hydroxychloroquine Among In-patients With Symptomatic Disease Completed · 430 cited
  3. Phase 3 To Evaluate The Effect Of SAR153191 (REGN88) Added To Other RA Drugs In Patients With RA Who Are Not Responding To Or Intolerant Of Anti-TNF Therapy (SARIL-RA-TARGET) Completed · 209 cited
  4. Phase 3 Pre-exposure Prophylaxis for SARS-Coronavirus-2 Completed · 128 cited
  5. Phase 3 To Evaluate The Safety of SAR153191 (REGN88) and Tocilizumab Added to Other RA Drugs in Patients With RA Who Are Not Responding to or Intolerant of Anti-TNF Therapy (SARIL-RA-ASCERTAIN) Completed · 124 cited
  6. Phase 3 Hydroxychloroquine for COVID-19 Post-exposure Prophylaxis (PEP) Completed · 93 cited
Show 31 more trials
  1. Phase 4 Treatments Against RA and Effect on FDG-PET/CT Completed · 73 cited
  2. Phase 4 IL-7 and IL-7R Expression in RA Patients With Active vs. Inactive Disease Treated With DMARD or CIMZIA Completed · 70 cited
  3. Phase 3 A Study of Subcutaneous Tocilizumab as Monotherapy and/or in Combination With Non-Biologic Disease Modifying Anti-Rheumatic Drugs (DMARDs) in Participants With Rheumatoid Arthritis Completed · 37 cited
  4. Phase 3 To Evaluate Sarilumab - SAR153191 (REGN88) - Auto-injector Device In Patients With Rheumatoid Arthritis Completed · 28 cited
  5. Phase 3 Healthcare Worker Exposure Response and Outcomes of Hydroxychloroquine Completed · 16 cited
  6. Phase 4 Effect of Sarilumab on Patient-reported Outcomes in Patients With Active Rheumatoid Arthritis Completed
  7. Phase 4 Reducing Risk of Type 2 Diabetes: Hydroxychloroquine Use in Pre-Diabetes Completed
  8. Phase 4 Treatment of Early Aggressive Rheumatoid Arthritis (TEAR) Completed
  9. Phase 3 Hydroxychloroquine to Improve Insulin Sensitivity in Rheumatoid Arthritis Completed
  10. Phase 2 Hydroxychloroquine in Previously Treated Patients With Metastatic Pancreatic Cancer Completed
  11. Phase 2 Preventive Approach to Congenital Heart Block With Hydroxychloroquine Completed
  12. Phase 2 Study of Hydroxychloroquine and Aldesleukin in Renal Cell Carcinoma Patients (RCC) Completed
  13. Phase 2 LY3214996 +/- HCQ in Pancreatic Cancer Completed
  14. Phase 2 Study of Anti-Malarials in Incomplete Lupus Erythematosus Completed
  15. Phase 2 Hydroxychloroquine, Palbociclib, and Letrozole Before Surgery in Treating Patients With Estrogen Receptor Positive, HER2 Negative Breast Cancer Completed
  16. Phase 2 Hydroxychloroquine vs. Azithromycin for Hospitalized Patients With Suspected or Confirmed COVID-19 Completed
  17. Phase 2 Hydroxychloroquine, Capecitabine, Oxaliplatin, and Bevacizumab in Treating Patients With Metastatic Colorectal Cancer Completed
  18. Phase 2 Hydroxychloroquine in the Prevention of COVID-19 Infection in Healthcare Workers Completed
  19. Phase 2 Vorinostat Plus Hydroxychloroquine Versus Regorafenib in Colorectal Cancer Completed
  20. Phase 2 Modulation of Autophagy in Patients With Advanced/Recurrent Non-small Cell Lung Cancer - Phase II Completed
  21. Phase 2 Hydroxychloroquine and Metabolic Outcomes in Patients Undergoing TPAIT Completed
  22. Phase 2 Hydroxychloroquine for the Treatment of Hidradenitis Suppurativa Completed
  23. Phase 2 Study of Pre-surgery Gemcitabine + Hydroxychloroquine (GcHc) in Stage IIb or III Adenocarcinoma of the Pancreas Completed
  24. Phase 2 Hydroxychloroquine in Treating Patients With Rising PSA Levels After Local Therapy for Prostate Cancer Completed
  25. Phase 2 Hydroxychloroquine, Radiation, and Temozolomide Treating Patients With Newly Diagnosed Glioblastoma Multiforme Completed
  26. Phase 2 Hydroxychloroquine and Phlebotomy for Treating Porphyria Cutanea Tarda Completed
  27. Phase 2 Randomized Phase II Trial of Pre-Operative Gemcitabine and Nab Paclitacel With or With Out Hydroxychloroquine Completed
  28. Phase 2 University of Utah COVID-19 Hydrochloroquine Trial Completed
  29. Phase 2 Paricalcitol and Hydroxychloroquine in Combination With Gemcitabine and Nab-Paclitaxel for Advanced Pancreatic Cancer Completed
  30. Phase 1 To Determine the Safety of Regorafenib, Hydroxychloroquine, and Entinostat Metastatic Colorectal Cancer Completed
  31. N/A Rheumatoid Arthritis: Comparison of Active Therapies in Patients With Active Disease Despite Methotrexate Therapy Completed

Showing the 37 most-cited and recently-updated of 37 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Meta-analysis finds hydroxychloroquine does not reduce most pregnancy complications in SLE
Rheumatology Meta-analysis
Meta-analysis finds hydroxychloroquine does not reduce most pregnancy complications in SLE Hydroxychloroquine May Lower Risk of Fetal Growth Restriction in Lupus Pregnancy
This meta-analysis of observational studies and RCTs assessed hydroxychloroquine use in pregnant women with SLE. It found no significant red…
In lupus pregnancies, hydroxychloroquine was linked to lower risks of fetal growth restriction and gestational diabetes, but not other compl…
May 22, 2026
Systematic review and meta-analysis of herpes zoster risk in rheumatoid arthritis patients
Rheumatology Meta-analysis
Systematic review and meta-analysis of herpes zoster risk in rheumatoid arthritis patients Rheumatoid Arthritis Patients Face Higher Shingles Risk Than General Public
This systematic review and meta-analysis synthesized data on herpes zoster risk in rheumatoid arthritis patients. The pooled proportion of h…
People with rheumatoid arthritis have a much higher chance of getting shingles, and doctors must watch for specific risk factors like high s…
Frontiers May 9, 2026
Scoping Review Assesses Active Surveillance Systems for Antivirals and Corticosteroids in COVID-19
Drug Pipeline Sys. Review
Scoping Review Assesses Active Surveillance Systems for Antivirals and Corticosteroids in COVID-19 How Hospitals Tracked COVID Drug Risks in Real Time
This scoping review analyzed 15 publications from 9,183 literature records to evaluate active surveillance systems for COVID-19 medications …
This study shows how doctors tracked COVID drug safety in real time, helping patients get safer care during a crisis.
Frontiers Apr 24, 2026
Systematic review identifies specific medications significantly associated with drug-induced hyperpigmentation across diverse drug classes
Drug Pipeline Meta-analysis
Systematic review identifies specific medications significantly associated with drug-induced hyperpigmentation across diverse drug classes These Common Meds Might Be Darkening Your Skin
A systematic review and meta-analysis evaluated twenty-two studies regarding the incidence of drug-induced hyperpigmentation.
A major review reveals many common medicines can cause noticeable skin darkening.
Frontiers Apr 24, 2026
Oral tofacitinib monotherapy with fire needling induced marked regression of cutaneous Rosai-Dorfman disease lesions in a single patient
Neurology Sys. Review
Oral tofacitinib monotherapy with fire needling induced marked regression of cutaneous Rosai-Dorfman disease lesions in a single patient A pill and a heated needle tamed a stubborn face disease
This case report and literature review describes a 55-year-old female with refractory cutaneous Rosai-Dorfman disease who failed prior thera…
A woman whose face was covered in stubborn red nodules finally saw improvement when doctors tried a surprising combination that crossed medi…
Frontiers Apr 13, 2026
Systematic review links neutrophil extracellular trap dysregulation to pregnancy complications
Diabetes & Endocrinology Sys. Review
Systematic review links neutrophil extracellular trap dysregulation to pregnancy complications Web of White Blood Cells Linked to Pregnancy Risks
A systematic review of emerging evidence indicates that dysregulation of neutrophil extracellular trap (NET) formation and clearance is stro…
A sticky web of white blood cells meant to fight germs can instead trigger serious pregnancy risks like preeclampsia and preterm birth when …
Frontiers Apr 12, 2026
Hydroxychloroquine did not prevent SLE progression in incomplete lupus patients in randomized trial
Rheumatology RCT
Hydroxychloroquine did not prevent SLE progression in incomplete lupus patients in randomized trial Hydroxychloroquine did not slow disease progression in incomplete lupus patients over two years
A randomized, double-blind trial of 180 patients with incomplete lupus erythematosus found hydroxychloroquine did not reduce progression to …
Hydroxychloroquine failed to slow lupus progression in patients with early symptoms over two years, matching placebo results.
Apr 8, 2026
Phase 2 trial finds hydroxychloroquine does not prevent rheumatoid arthritis in at-risk individuals
Rheumatology RCT
Phase 2 trial finds hydroxychloroquine does not prevent rheumatoid arthritis in at-risk individuals Hydroxychloroquine did not prevent rheumatoid arthritis in at-risk individuals in trial
In a phase 2 randomized controlled trial of 144 individuals at risk for rheumatoid arthritis with elevated anti-CCP3 antibodies, 12 months o…
A new trial found that taking hydroxychloroquine for a year did not stop people at high risk for rheumatoid arthritis from developing the di…
Apr 7, 2026