Research across Systemic Lupus Erythematosus
Related studies from across the Systemic Lupus Erythematosus family.
Depressive symptoms affect about one third of patients with childhood-onset lupus, with tool-dependent variation
One in three children with lupus show signs of depression
This meta-analysis estimates the pooled prevalence of screening-positive depressive symptoms in childhood-onset systemic lupus erythematosus…
A large review of 652 patients shows that over 30% of children with childhood-onset lupus have symptoms of depression.
Autoimmune comorbidities recur with MS, but evidence cannot define a prodrome or distinct subgroups
Common autoimmune conditions often occur alongside multiple sclerosis
This scoping review synthesizes evidence on immune-mediated comorbidities in multiple sclerosis. Autoimmune thyroid disease, type 1 diabetes…
People with multiple sclerosis often have other autoimmune conditions like thyroid disease or psoriasis, but the link to disease progression…
Concurrent lupus nephritis and Graves' disease improved with combined immunosuppression and methimazole in a single case
Case Report Shows Treatment for Concurrent Lupus and Graves Disease
This case report describes a 39-year-old male with biopsy-proven ISN/RPS Class IV + V lupus nephritis and Graves' disease who showed early c…
A new case report describes a treatment plan for a patient managing both lupus nephritis and Graves disease at the same time.
IL-5/IL-5Rα blockade provides clinically validated benefit in EGPA but requires phenotype-specific evidence for other conditions
Targeting Eosinophils Shows Promise for Specific Autoimmune Conditions
This narrative review explores the role of eosinophils and IL-5/IL-5Rα and IL-4Rα blockade in various autoimmune diseases. The authors concl…
New research highlights how targeting specific immune cells like eosinophils can help manage certain inflammatory and autoimmune diseases.
Telitacicept Shows Satisfactory Response in Complex Overlap Syndrome Case
Telitacicept Shows Potential in Rare Overlap Syndrome Case
This is a single case report describing a patient with systemic lupus erythematosus, immune-mediated necrotizing myopathy, Sjögren's syndrom…
A single case report describes a patient with four autoimmune conditions who responded well to a regimen containing telitacicept.
2024 ACR guidelines for lupus nephritis require caution in pediatric practice due to adult-derived evidence
Adult Lupus Kidney Guidelines May Not Fit Children
This guideline review examines the application of 2024 ACR guidelines for lupus nephritis in pediatric patients. While core principles are a…
New lupus nephritis guidelines cover kids, but most of the evidence behind them comes from adults.
BAFF and APRIL signaling pathways drive pathogenic autoantibody production in IgA nephropathy and lupus nephritis
Biologic Therapies Target Specific Pathways in Kidney Diseases
This systematic review examines the role of BAFF and APRIL signaling pathways in IgA nephropathy, lupus nephritis, and primary membranous ne…
Newer biologic treatments are targeting specific immune pathways to manage conditions like IgA nephropathy and lupus nephritis.
Arthritis affects 60.68% of SLE patients in Pakistan, with regional and temporal variation
More patients with lupus develop arthritis in recent years
This meta-analysis of 10 studies estimates the pooled prevalence of arthritis in patients with systemic lupus erythematosus in Pakistan at 6…
A new look at data shows that over 60% of lupus patients in Pakistan have arthritis, with rates rising in more recent studies.
Corticosteroids are the first-line treatment for patients with systemic lupus erythematosus and shrinking lung syndrome
Corticosteroids May Help Rare Lupus Lung Complication
This systematic review examines the clinical presentation and management of shrinking lung syndrome in patients with systemic lupus erythema…
A rare lupus lung problem often starts with breathlessness, and steroids were the most common first treatment in a review of 120 cases.
Prolactin and estradiol levels are elevated in patients with active systemic lupus erythematosus
Hormone levels vary in people with systemic lupus erythematosus
This meta-analysis of 5389 individuals with systemic lupus erythematosus (SLE) found significantly higher prolactin and estradiol levels in …
New data shows that people with systemic lupus erythematosus often have different hormone levels, especially during active periods of the di…
Higher mycophenolic acid levels correlate with 12-fold higher odds of clinical response in SLE
Higher Mycophenolic Acid Levels Linked to Better Lupus Response
This systematic review and meta-analysis of 24 studies indicates that higher mycophenolic acid (MPA) levels are associated with improved cli…
Higher levels of the medication mycophenolic acid are linked to better clinical responses in patients with systemic lupus erythematosus.
Rituximab-based therapy associated with moderate renal response and reduced proteinuria in relapsing lupus nephritis
Rituximab Shows Promise for Managing Difficult Lupus Nephritis Cases
This meta-analysis of 445 patients evaluated rituximab-based rescue or add-on therapy for relapsing or refractory lupus nephritis. The analy…
Rituximab may help manage kidney damage in patients with difficult-to-treat lupus nephritis by improving renal response and lowering protein…