Research across Systemic Lupus Erythematosus
Related studies from across the Systemic Lupus Erythematosus family.
Deep learning models show high sensitivity and specificity for SLE and lupus nephritis diagnosis
Machine Learning Models Show Promise for Diagnosing Lupus Conditions
This meta-analysis of 29 studies evaluated the diagnostic performance of machine learning and deep learning models for SLE, lupus nephritis,…
New analysis shows deep learning models may offer high accuracy in identifying various types of lupus and related kidney or neurological con…
Voclosporin doubles proteinuria reduction in lupus nephritis but raises adverse events
Voclosporin Shows Better Results for Lupus Nephritis Protein Reduction
This meta-analysis of randomized controlled trials in 770 adults with lupus nephritis found that adding voclosporin to standard treatment si…
Adding voclosporin to standard treatment may help reduce protein in the urine for adults with Lupus Nephritis, though it carries higher safe…
No direct evidence exists regarding altered ncRNA levels in breast milk from mothers with SLE
Breast Milk RNA in Lupus Mothers: What We Know
This literature review examines the presence of ncRNA molecules in human breast milk and their potential impact on the neonatal immune syste…
A review finds no direct proof that lupus changes RNA in breast milk, but highlights the need for more research on infant immunity.
High disease activity in paediatric SLE is associated with increased risk of multisystem involvement
High disease activity linked to organ damage in children with lupus
This meta-analysis of 4934 paediatric patients with systemic lupus erythematosus (pSLE) indicates that high disease activity is associated w…
Children with high disease activity in lupus are much more likely to experience serious complications like kidney damage and neurological is…
Obinutuzumab improves SRI-4 response by 23.1 percentage points in active systemic lupus erythematosus
Trial shows obinutuzumab improves outcomes for systemic lupus erythematosus
This Phase 3 randomized controlled trial of 303 adults with active systemic lupus erythematosus found obinutuzumab significantly superior to…
A new clinical trial shows that obinutuzumab significantly improved response rates for adults with active systemic lupus erythematosus compa…
Aortic root and coronary ostium involvement in Libman-Sacks endocarditis: a rare case
Rare Heart Complications Found in Patient with Lupus and Syndrome
This case report describes a 25-year-old woman with systemic lupus erythematosus and antiphospholipid syndrome who developed Libman-Sacks en…
A single case report reveals a patient with lupus and antiphospholipid syndrome who developed a rare, life-threatening heart valve obstructi…
cGAS-STING pathway activation drives inflammation, fibrosis, and podocyte injury in various kidney diseases
New research identifies a key pathway in kidney disease progression
This systematic review synthesizes preclinical data on the cGAS-STING signaling pathway's role in acute kidney injury, chronic kidney diseas…
A specific signaling pathway called cGAS-STING acts as a central hub, linking inflammation and metabolism to several types of serious kidney…
Natural products like polysaccharides and TCM formulas may modulate gut microbiota to protect renal function
Natural Products May Help Manage Chronic Kidney Disease Symptoms
This systematic review examines the role of natural polysaccharides, traditional Chinese medicine formulas, and plant polyphenols in modulat…
Natural compounds like plant polyphenols may help protect the kidneys by improving gut health and reducing inflammation in patients with kid…
Chemokine network emerges as rational lupus nephritis target as standard therapy fails 30% to 40%
Chemokine Networks May Offer New Targets for Lupus Nephritis
This systematic review synthesizes evidence on the chemokine network in lupus nephritis, highlighting its role in driving immune cell infilt…
New research identifies the chemokine system as a potential target to improve treatment for patients with lupus nephritis and systemic lupus…
High-risk APOL1 genotypes more than double odds of lupus nephritis ESRD
High Risk APOL1 Genotypes Linked to Kidney Damage in Lupus
This meta-analysis of 1,885 patients of African ancestry with systemic lupus erythematosus found that high-risk APOL1 genotypes were associa…
A specific genetic marker called APOL1 may signal an increased risk of end-stage renal disease for patients with lupus and kidney involvemen…
CAR T-cell therapy targeting CD19 or BCMA may induce sustained remission in specific autoimmune diseases
CAR T-cell Therapy Shows Potential for Autoimmune Disease Remission
This systematic review examines CAR T-cell therapies for patients with systemic lupus erythematosus, idiopathic inflammatory myopathy, and s…
A new type of cell therapy may offer a way to reset the immune system in patients with lupus, scleroderma, and inflammatory myopathy.
Seven genome-wide significant loci and eight HLA alleles associated with shingles susceptibility identified
Genetic Links Connect Shingles to Stroke and Lupus Risk
This meta-analysis of a large genome-wide association study identifies seven genomic loci, including IGHG1 and IFNAR2, linked to shingles. M…
New research identifies specific genetic markers for shingles and suggests a potential link between the virus and conditions like stroke and…