Research across Systemic Lupus Erythematosus
Related studies from across the Systemic Lupus Erythematosus family.
Dapirolizumab pegol increases BICLA response rate by 14.6% over placebo in moderate-to-severe SLE
Trial shows dapirolizumab pegol improves symptoms for lupus patients
This Phase 3 randomized controlled trial of 321 patients with moderate-to-severe, active SLE found that dapirolizumab pegol added to standar…
A new clinical trial found that dapirolizumab pegol significantly improved disease activity for adults with moderate to severe systemic lupu…
SLE patients have a 2- to 3-fold higher risk of intracerebral hemorrhage compared to non-SLE populations
Lupus Patients Face Higher Risk of Brain Bleeding
This literature review and case report analyze the association between systemic lupus erythematosus (SLE) and intracranial hemorrhage (ICH).…
Patients with systemic lupus erythematosus may face a much higher risk of brain bleeds compared to those without the condition.
Systemic immune-inflammation index and systemic inflammation response index correlate with disease activity in systemic lupus erythematosus
Inflammation markers are higher in lupus patients than in healthy people
This meta-analysis of eleven studies involving individuals with systemic lupus erythematosus and healthy controls examined inflammatory mark…
A new analysis shows inflammation markers are much higher in people with lupus. These markers also track closely with how active the disease…
Stress-induced IL-6 upregulation impairs skeletal growth and bone health in children with inflammatory diseases
Stress hormones may harm bone growth in children with inflammatory conditions
This narrative review synthesizes evidence from animal models and pediatric inflammatory disorders showing that stress-induced IL-6 upregula…
A review suggests stress-induced IL-6 upregulation impairs skeletal growth and bone health in kids with inflammatory disorders, highlighting…
Adrenal insufficiency is first manifestation in 73.6% of APS patients with adrenal involvement
Review finds adrenal crisis common in lupus and antiphospholipid syndrome cases
This systematic review and pooled individual-patient analysis of 155 published APS/SLE-spectrum patients with adrenal involvement found that…
A review of 155 patients shows adrenal crisis is frequent in lupus and antiphospholipid syndrome, highlighting the need for urgent care.
STAT3 inhibition targets cytokine signaling and renal inflammation in systemic lupus erythematosus and lupus nephritis
New review suggests STAT3 inhibition could help lupus kidney disease
This narrative review examines the role of STAT3 in systemic lupus erythematosus and lupus nephritis. The authors argue that STAT3 integrate…
A narrative review suggests targeting STAT3 might treat lupus kidney inflammation, though direct drug targeting remains unproven in patients…
SLE linked to 53% higher odds of cognitive impairment in meta-analysis of 7 million
Lupus linked to higher risk of cognitive decline
This meta-analysis of 7 observational studies involving over 7 million participants found that systemic lupus erythematosus (SLE) is signifi…
People with lupus may face 53% higher odds of cognitive impairment, a large analysis finds.
Epstein–Barr virus infection shows higher seropositivity and viral loads in systemic lupus erythematosus patients compared to healthy controls
Epstein-Barr virus linked to lupus in new review of patient data
A mini review highlights that Epstein–Barr virus infection is more prevalent and active in patients with systemic lupus erythematosus than i…
A new review finds that Epstein-Barr virus is more common and active in lupus patients, suggesting a role in the disease.
Subcutaneous anifrolumab improves BICLA response by 15.5% in moderate to severe SLE
Anifrolumab injection improves lupus outcomes in trial
This phase 3 RCT in 367 adults with moderate to severe SLE found that subcutaneous anifrolumab 120 mg weekly plus standard therapy improved …
A weekly injection of anifrolumab helped more people with lupus achieve disease control than placebo, a phase 3 trial shows.
Tubulointerstitial inflammation and fibrosis predict renal function decline in adult lupus nephritis patients across multiple studies
Kidney damage in lupus is linked to specific tissue changes seen in scans
A systematic review of 3,607 adult patients reveals that tubulointerstitial inflammation and fibrosis significantly increase the risk of ren…
A large review found that kidney tissue changes called tubulointerstitial inflammation and fibrosis raise the risk of kidney failure in lupu…
Core set domains capture SLE treatment response in 89.5% of cases at week 52
Core set domains capture most lupus disease activity in a global trial
This phase III randomized controlled trial evaluated subjects with Systemic Lupus Erythematosus across a global setting. The study compared …
A global trial found that a core set of domains captured most lupus disease activity without missing important patient responses.
Meta-analysis finds hydroxychloroquine does not reduce most pregnancy complications in SLE
Hydroxychloroquine May Lower Risk of Fetal Growth Restriction in Lupus Pregnancy
This meta-analysis of observational studies and RCTs assessed hydroxychloroquine use in pregnant women with SLE. It found no significant red…
In lupus pregnancies, hydroxychloroquine was linked to lower risks of fetal growth restriction and gestational diabetes, but not other compl…