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Home › Medications › insulin

insulin

27 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials of insulin

56 trials tracked of insulin: 31 in phase 3 or 4 and 17 with published results. The most-cited published study has 156 citations.

56Trials tracked
31Phase 3 & 4
0Recruiting
17With published results
Phase distribution
Phase 4 19 Phase 3 12 Phase 2 10 Phase 1 5 Other / NA 10
  1. Phase 3 Safety and Efficacy of Ertugliflozin in the Treatment of Participants With Type 2 Diabetes Mellitus Who Have Inadequate Glycemic Control on Metformin and Sitagliptin (MK-8835-006; VERTIS SITA2) Completed · 156 cited
  2. Phase 4 Nephropathy In Type 2 Diabetes and Cardio-renal Events Completed · 129 cited
  3. Phase 3 Validation of Macimorelin as a Test for Adult Growth Hormone Deficiency Completed · 115 cited
  4. Phase 3 Diabetes Study of Linagliptin and Empagliflozin in Children and Adolescents (DINAMO)TM Completed · 109 cited
  5. Phase 4 Study of Management of Pasireotide-induced Hyperglycemia in Adult Patients With Cushing's Disease or Acromegaly Completed · 80 cited
  6. Phase 4 Effect of Dapagliflozin on 24-hour Blood Glucose in T2DM Patients Inadequately Controlled With Either Metformin Or Insulin Completed · 79 cited
Show 44 more trials
  1. Phase 3 Dapagliflozin As Additional Treatment To Liraglutide And Insulin In Patients With Type 1 Diabetes Completed · 71 cited
  2. Phase 4 Efficacy and Safety Study of Canagliflozin (TA-7284) in Combination With Insulin in Patients With Type 2 Diabetes Mellitus Completed · 70 cited
  3. Phase 3 A Pooled Analysis of the Safety and Efficacy of MK-0431A and MK-0431A XR in Pediatric Participants With Type 2 Diabetes Mellitus With Inadequate Glycemic Control on Metformin Therapy (Alone or in Combination With Insulin) (MK-0431A-170/MK-0431A-289) Completed · 31 cited
  4. Phase 3 Heart And Lung Failure - Pediatric INsulin Titration Trial Completed · 26 cited
  5. Phase 4 Efficacy and Safety Study of Teneligliptin (MP-513) in Combination With Insulin in Patients With Type 2 Diabetes Completed · 25 cited
  6. Phase 4 Study of Glycemic Control on Liver Transplantation Outcomes Completed · 23 cited
  7. Phase 3 A Study of Omarigliptin (MK-3102) in Participants With Type 2 Diabetes Mellitus With Chronic Kidney Disease or Kidney Failure on Dialysis (MK-3102-019) Completed · 21 cited
  8. Phase 4 Intravenous Insulin vs Subcutaneous Insulin Infusion in Intrapartum Management of Type 1 Diabetes Mellitus Completed · 15 cited
  9. Phase 4 Long-Term Safety Study of Canagliflozin (TA-7284) in Combination With Insulin in Patients With Type 2 Diabetes Mellitus Completed · 14 cited
  10. Phase 4 Intraoperative Glucose Control in Liver Transplant Completed · 14 cited
  11. Phase 4 Omarigliptin Add-on to Insulin in Japanese Participants With Type 2 Diabetes Mellitus (T2DM, MK-3102-039) Completed · 4 cited
  12. Phase 4 Use of Exenatide and Pramlintide to Decrease Post-prandial Hyperglycemia Completed
  13. Phase 4 Post-meal Insulin Dosing With Adjuvant Pre-meal Pramlintide in Children With Type 1 Diabetes Mellitus Completed
  14. Phase 4 Post-marketing Clinical Trial of KAD-1229 in Patients With Type 2 Diabetes Mellitus Completed
  15. Phase 4 Metabolic Analysis for Treatment Choice in Gestational Diabetes Mellitus Completed
  16. Phase 4 Comparison of Meal-Time Dosing of Insulin in Cystic Fibrosis Related Diabetes Completed
  17. Phase 4 Diabetes in the Elderly: Prospective Study Completed
  18. Phase 4 Strict Glycemic Control by Insulin Infusion:Observations on Emergency Department Initiation Completed
  19. Phase 4 Metformin Versus Insulin in Gestational Diabetes Completed
  20. Phase 4 Study of Efficacy and Safety of Vildagliptin as add-on Insulin Therapy in T2DM Patients Completed
  21. Phase 3 Ertugliflozin Type 2 Diabetes Mellitus (T2DM) Pediatric Study (MK-8835/PF-04971729) (MK-8835-059) Completed
  22. Phase 3 Efficacy and Safety of Liraglutide in Combination With Insulin Therapy Compared to Insulin Alone in Japanese Subjects With Type 2 Diabetes Completed
  23. Phase 3 Glycemic Control and Complications in Diabetes Mellitus Type 2 (VADT) Completed
  24. Phase 3 A Study in China Evaluating the Safety and Efficacy of Adding Sitagliptin to Stable Therapy With Insulin With or Without Metformin in Participants With Type 2 Diabetes Mellitus (T2DM) (MK-0431-254) Completed
  25. Phase 3 Efficacy and Safety Study of Alogliptin and Insulin in the Treatment of Type 2 Diabetes. Completed
  26. Phase 2 Effectiveness of Metformin Compared to Insulin in Pregnant Women With Mild Preexisting or Early Gestational Diabetes Completed
  27. Phase 2 Intranasal Insulin for Improving Cognitive Function in Multiple Sclerosis Completed
  28. Phase 2 Study of Nasal Insulin to Fight Forgetfulness - Device Study Completed
  29. Phase 2 Autologous Stem Cell and Hyperbaric Oxygen Therapy in Type 2 Diabetes Mellitus Completed
  30. Phase 2 Study of Nasal Insulin to Fight Forgetfulness - Long-acting Insulin Detemir - 120 Days (SL120) Completed
  31. Phase 2 Role of Exenatide in Type 1 Diabetes Completed
  32. Phase 2 A Study to Test MK-0941 in Adults With Type 2 Diabetes Mellitus With Inadequate Glycemic Control on Insulin (MK-0941-018) Completed
  33. Phase 2 A Study to Evaluate a Potassium Normalization Treatment Regimen Including Sodium Zirconium Cyclosilicate (ZS) Among Patients With S-K ≥5.8 Completed
  34. Phase 2 Albiglutide Versus Placebo in Insulin-treated Subjects With New-onset Type 1 Diabetes Mellitus Completed
  35. Phase 2 Early Insulin and Development of ARDS Completed
  36. Phase 1 Investigating the Role of the Polyol Pathway in the Central Nervous System Production of Fructose Completed
  37. Phase 1 Single Ascending Dose Study of MK-1092 in Healthy Participants and in Participants With Type 1 and Type 2 Diabetes Mellitus (MK-1092-001) Completed
  38. Phase 1 Effect of LY2189265 on Insulin Secretion in Response to Intravenous Glucose Completed
  39. Phase 1 Mechanisms for Restoration of Hypoglycemia Awareness Completed
  40. Phase 1 Effect of Hyperglycemia on Microvascular Perfusion in Healthy Adults Completed
  41. N/A Glycemic Control Using Insulin Levemir Versus Insulin NPH for Diabetes in Pregnancy Completed
  42. N/A Physiologic Response to Glucagon at Varying Insulin Levels Completed
  43. N/A Resolution of Type 2 Diabetes Mellitus: Intensive vs. Conventional Glycaemic Control After Obesity Surgery Completed
  44. N/A Preservation of Beta-cell Function in Type 2 Diabetes Mellitus Completed

Showing the 50 most-cited and recently-updated of 56 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Tubeless automated insulin delivery reduces HbA1c more than multiple daily injections in type 1 diabetes
Diabetes & Endocrinology RCT
Tubeless automated insulin delivery reduces HbA1c more than multiple daily injections in type 1 diabetes Tubeless insulin pump system helps lower blood sugar better than injections in study
A 13-week randomized controlled trial in 188 children and adults with type 1 diabetes and elevated HbA1c found that tubeless automated insul…
A tubeless insulin pump system lowered average blood sugar better than injections for people with type 1 diabetes in a new study.
Apr 3, 2026
Tight glycemic targets in GDM reduce LGA births and cesarean rates but increase insulin use
Diabetes & Endocrinology RCT
Tight glycemic targets in GDM reduce LGA births and cesarean rates but increase insulin use Can stricter blood sugar targets during pregnancy lead to healthier births?
A single-center, open-label RCT of 650 women with GDM found tight glycemic targets (fasting <5.1 mmol/L, postprandial <7.0 mmol/L) reduced L…
Stricter blood sugar targets for pregnant women with diabetes lower risks of large babies and C-sections but require more insulin therapy.
Apr 3, 2026
Game-based education improves treatment compliance and reduces anxiety in adults starting insulin for type 2 diabetes
Psychiatry RCT
Game-based education improves treatment compliance and reduces anxiety in adults starting insulin for type 2 diabetes Could playing a game help people stick with their new insulin treatment?
A randomized controlled trial of 72 adults with type 2 diabetes starting insulin therapy compared a game-based education program to standard…
A game-based education program helped adults with type 2 diabetes stick to their new insulin shots and feel less anxious compared to standar…
Apr 3, 2026