Balanced crystalloids reduce time to DKA resolution by 1.60 hours compared to 0.9% saline
Balanced Crystalloids May Speed Recovery in Pediatric Diabetic Ketoacidosis
This meta-analysis of 320 pediatric patients with diabetic ketoacidosis found that balanced crystalloids significantly reduced the time to D…
A review of data suggests balanced crystalloid fluids may resolve diabetic ketoacidosis faster than standard saline in children.
Early subcutaneous basal insulin plus IV insulin reduces time to DKA resolution by 4.06 hours
Early Subcutaneous Insulin Shortens Recovery Time for Diabetic Ketoacidosis
This meta-analysis of randomized controlled trials evaluated adding early subcutaneous basal insulin to intravenous insulin for adults with …
Adding early subcutaneous insulin to IV treatment can speed up recovery for patients with diabetic ketoacidosis without increasing safety ri…
SGLT2 inhibitor use associated with increased diabetic ketoacidosis risk, especially with elevated HbA1c
New review shows SGLT2 drugs raise DKA risk when blood sugar is high
This meta-analysis of observational and randomized trials found SGLT2 inhibitor use is associated with an increased risk of diabetic ketoaci…
A big review of many studies found that medicines for diabetes called SGLT2 inhibitors can increase the chance of a serious condition called…
Scoping review maps burden of diabetic emergencies in African healthcare settings
Diabetic emergencies in Africa show wide variation in rates and outcomes
This scoping review synthesizes data from 25 studies regarding diabetic emergencies in Africa. The authors report wide variation in reported…
A review of 25 studies finds diabetic emergencies in Africa vary widely, with high death rates and long hospital stays.
Review of 16 cases shows 25% mortality for pulmonary mucormycosis in DKA patients treated with amphotericin B
Treatment for rare lung infection kills one in four patients with diabetic ketoacidosis
This case report and literature review synthesizes data from 16 patients with diabetic ketoacidosis complicated by invasive pulmonary mucorm…
A review of 16 patients found that one in four died from this rare lung infection. Early diagnosis and surgery are key.
Review of immune checkpoint inhibitor-associated diabetes mellitus in two patients
Diabetes Danger Lingers Months After Cancer Treatment Ends
This narrative review and case report describes two patients with immune checkpoint inhibitor-associated diabetes mellitus. The authors synt…
• Some patients develop dangerous diabetes long after stopping immunotherapy • Helps cancer survivors using newer immune-boosting drugs • St…
Cadonilimab therapy in cervical cancer associated with new-onset type 1 diabetes and diabetic ketoacidosis in a case report
A Cancer Drug Triggered Sudden Diabetes in an 81-Year-Old
This systematic review includes a case report of an 81-year-old female with cervical squamous cell carcinoma who developed diabetic ketoacid…
A powerful cancer drug can switch off the body's insulin supply almost overnight, causing sudden, life-threatening diabetes in patients with…
Capnography shows high diagnostic accuracy for diabetic ketoacidosis in meta-analysis
Capnography shows promise for detecting diabetic ketoacidosis in early research
A meta-analysis of 7 observational studies including 1,123 diabetic patients found capnography had 91% sensitivity and 90% specificity for d…
A simple breath test that measures carbon dioxide levels could help doctors spot dangerous diabetic ketoacidosis earlier by correctly identi…
Research across Diabetes
Related studies from across the Diabetes family.
AI-OCT reports reduced false-positive DME referral rates from 69.1% to 24.1%
AI technology reduces unnecessary referrals for diabetic macular edema
This randomized clinical trial evaluated the impact of AI-OCT reports on identifying diabetic macular edema (DME) in patients with diabetes.…
New research shows that adding AI-powered imaging can significantly cut down on false alarms when screening patients for eye issues caused b…
Vitamin D supplementation shows low certainty reductions in urinary markers for diabetic kidney disease
Vitamin D shows limited benefit for diabetic kidney disease
This umbrella review meta-analysis evaluates vitamin D and its analogs in patients with diabetic kidney disease. While some reduction in uri…
Vitamin D may lower protein in urine for diabetic kidney disease, but evidence is weak and no benefit for kidney function or survival.
Fluocinolone Acetonide Implant Shows Reduced Injection Frequency for Diabetic Macular Edema
Fluocinolone Acetonide Implant May Reduce Injection Frequency for DME
A Phase 4 trial shows fluocinolone acetonide implants achieve similar visual outcomes to aflibercept with significantly fewer total injectio…
A new eye implant for diabetic macular edema may significantly reduce the number of monthly injections needed to maintain vision.
miR-29a-3p and miR-204-5p are downregulated in diabetic nephropathy as potential biomarker candidates
Specific MicroRNA Signatures Linked to Type 1 Diabetes Complications
This systematic review and meta-analysis of 9 studies involving 34 contrasts identified specific circulating miRNA signatures associated wit…
Researchers identified specific microRNA signals that may help track kidney and eye damage in patients with Type 1 Diabetes.
High prevalence of microvascular and macrovascular complications among adult Ugandans with diabetes
High rates of diabetes complications found in adult Ugandans
This meta-analysis examined the prevalence of various diabetic complications, including neuropathy and retinopathy, in a large cohort of adu…
More than half of Ugandan adults with diabetes suffer from nerve damage, highlighting a critical need for earlier screening and better care.
Immunometabolic dysregulation drives hyperalgesia and hypoesthesia in diabetic peripheral neuropathy
New research explores how inflammation drives nerve damage in diabetes
This narrative review explores the pathophysiology of diabetic peripheral neuropathy, focusing on how hyperglycemia, lipotoxicity, and intes…
Chronic high blood sugar causes more than just high glucose; it triggers a cycle of inflammation and immune stress that damages nerves.
Chronic hyperglycemia causes multi-level nerve damage across the peripheral, autonomic, and central nervous systems
Understanding how high blood sugar damages the entire nervous system in diabetes
This narrative review synthesizes how chronic hyperglycemia impacts the entire neuroaxis in patients with diabetes. It details metabolic and…
High blood sugar can damage nerves throughout the whole body. This affects your senses, movement, and internal organs.
Intravitreal ziv-aflibercept reduces central macular thickness and improves visual acuity in DME and RVO
Trial shows ziv-aflibercept improves vision in macular edema cases
This systematic review and meta-analysis of 5 RCTs and 8 observational studies found that intravitreal ziv-aflibercept significantly reduced…
A new eye treatment called ziv-aflibercept may help reduce swelling and improve vision for patients with specific types of macular edema.
Local antibiotic delivery systems increase healing rates in diabetic foot osteomyelitis compared with control groups in this meta-analysis
Local Antibiotics May Boost Healing in Diabetic Foot Infections
This systematic review and meta-analysis evaluated local antibiotic delivery systems versus control groups for patients with diabetic foot o…
A new analysis suggests local antibiotic delivery may improve healing for diabetic foot bone infections, but more research is needed.
Antibiotic cement achieves 85.2% healing rate in diabetic foot osteomyelitis meta-analysis
Antibiotic cement may help heal diabetic foot infections without major surgery
A systematic review and meta-analysis of 82 patients with diabetic foot osteomyelitis found a weighted healing rate of 85.2% with antibiotic…
A meta-analysis suggests antibiotic-impregnated cement can heal diabetic foot osteomyelitis in most patients, though some still need surgery…
Perioperative anti-VEGF injections improve vision and reduce bleeding in proliferative diabetic retinopathy
Anti-VEGF injections before eye surgery improve vision and reduce bleeding in diabetic retinopathy
This network meta-analysis evaluated the timing of perioperative anti-VEGF injections for proliferative diabetic retinopathy. Results indica…
A network meta-analysis of 2,646 eyes found that perioperative anti-VEGF injections improved vision and reduced bleeding in patients with pr…
Exosomes show promise as biomarkers and therapeutic vectors in diabetic complications
Review suggests exosomes may help target multiple diabetes complications
This narrative review explores the role of exosomes in diabetic kidney disease, retinopathy, and peripheral neuropathy. It highlights their …
A narrative review suggests exosomes might inform strategies to target multiple diabetes complications together, though clinical standardiza…
Questions about Diabetic Ketoacidosis
How accurate is capnography for detecting diabetic ketoacidosis?
Capnography shows high diagnostic accuracy for detecting diabetic ketoacidosis by showing significantly lower carbon dioxide levels in affected patients compared to those without the condition.
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