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Home › Medications › melatonin

melatonin

15 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials of melatonin

19 trials tracked of melatonin: 6 in phase 3 or 4 and 3 with published results. The most-cited published study has 81 citations.

19Trials tracked
6Phase 3 & 4
0Recruiting
3With published results
Phase distribution
Phase 3 6 Phase 2 10 Phase 1 1 Other / NA 2
  1. Phase 3 Anxiolytic and Analgesic Effects of Melatonin Completed · 81 cited
  2. Phase 3 Melatonin for Fatigue and Other Symptoms in Patients With Advanced Cancer Completed · 50 cited
  3. Phase 3 Comparing the Effect of Melatonin, Diazepam, and Placebo on Decreasing the Level of Anxiety Preoperatively Completed · 1 cited
  4. Phase 3 Melatonin Intervention For Neurocognitive Deficits in the St. Jude Lifetime Cohort Completed
  5. Phase 3 Getting SMART for Pediatric Epilepsy Completed
  6. Phase 3 Melatonin Versus Placebo and the Effect on Appetite in Advanced Cancer Patients Completed
Show 13 more trials
  1. Phase 2 Melatonin Supplements for Improving Sleep in Individuals With Hypertension Completed
  2. Phase 2 Melatonin and Nighttime Blood Pressure in African Americans-8 mg Study Completed
  3. Phase 2 Melatonin and Nighttime Blood Pressure in African Americans--24 mg Study Completed
  4. Phase 2 Pilot Study of Melatonin and Epilepsy Completed
  5. Phase 2 Improving Sleep and Daytime Functioning Among Children Diagnosed With Attention Deficit Hyperactivity Disorder (ADHD) Completed
  6. Phase 2 Combined Drug Approach to Prevent Ischemia-reperfusion Injury During Transplantation of Livers (CAPITL) Completed
  7. Phase 2 Melatonin and the Metabolic Syndrome Completed
  8. Phase 2 Sleep Management And Recovery After Traumatic Brain Injury in Kids: Pilot Intervention of Melatonin Completed
  9. Phase 2 Bringing Relief to Adolescents Naturally Using Melatonin for Migraine Completed
  10. Phase 2 CHOCOlate MeLatonin for AdolescenT MigrainE Completed
  11. Phase 1 Multiple Dose Study Of BIIB118 (PF-05251749) In Healthy Volunteers Completed
  12. N/A Treatment of Osteopenia With Melatonin Completed
  13. N/A Study of Melatonin on Sleep, Pain, and Confusion After Joint Replacement Surgery Completed

Showing the 19 most-cited and recently-updated of 19 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Oral melatonin adjunct therapy improves echocardiographic parameters and clinical outcomes in neonates with persistent pulmonary hypertension of the newborn
Pediatrics RCT
Oral melatonin adjunct therapy improves echocardiographic parameters and clinical outcomes in neonates with persistent pulmonary hypertension of the newborn Could The Sleep Hormone Help Newborn Hearts Heal Faster?
This randomized controlled trial evaluated oral melatonin added to standard therapy versus standard therapy alone in 80 neonates with persis…
Adding melatonin to standard care helped newborn hearts pump stronger and got babies off ventilators sooner in a careful 80-baby trial.
Apr 13, 2026
High-dose melatonin linked to hepatotoxicity in small PP-MS trial, prompting early halt
Neurology RCT
High-dose melatonin linked to hepatotoxicity in small PP-MS trial, prompting early halt High-dose melatonin trial halted after liver safety concerns in MS patients
A phase I/II RCT of 8 patients with PP-MS on stable ocrelizumab found that adjunctive high-dose oral melatonin (300 mg/day) was associated w…
A high-dose melatonin trial for multiple sclerosis stopped early after three of four patients developed mild liver injury, though the issue …
Apr 4, 2026
Emergency department visits for unsupervised melatonin ingestion in infants and young children reported
Pediatrics
Emergency department visits for unsupervised melatonin ingestion in infants and young children reported Are more young children ending up in emergency rooms after eating melatonin?
An observational report describes emergency department visits in the US for unsupervised melatonin ingestion among infants and young childre…
A new report tracks emergency room visits for infants and young children who ate melatonin without supervision.
CDC Apr 4, 2026