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Home › Conditions › Phantom Limb Pain

Phantom Limb Pain

2 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Phantom Limb Pain

9 trials tracked for Phantom Limb Pain: 1 in phase 3 or 4 and 1 with published results. The most-cited published study has 43 citations.

9Trials tracked
1Phase 3 & 4
0Recruiting
1With published results
Phase distribution
Phase 4 1 Other / NA 8
  1. Phase 4 Treating Phantom Limb Pain Using Continuous Peripheral Nerve Blocks: A Department of Defense Funded Multicenter Study Completed · 43 cited
  2. N/A C-RFA of Residual Limb Neuroma Completed
  3. N/A Pulsed Electromagnetic Fields for Post-Amputation Pain Completed
  4. N/A Electrical Stimulation for the Treatment of Post-Amputation Pain Using the SPRINT System Completed
  5. N/A Virtual Reality for Phantom Limb Pain Completed
  6. N/A Mixed Reality Based System to Manage Phantom Pain Phantom Pain for Patients With Lower Limb Amputation Completed
Show 3 more trials
  1. N/A Cryoanalgesia to Treat Phantom Limb Pain Following Above-Knee Amputation Completed
  2. N/A Postoperative Peripheral Nerve Stimulation for Management of Post-amputation Pain Completed
  3. N/A Predicting Pain Response to Transcranial Direct Current Stimulation for Phantom Limb Pain in Limb Amputees Completed

Showing the 9 most-cited and recently-updated of 9 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

What the trials found Updated — new results For clinicians

Phantom Limb Pain: what the trials found

Evidence for the management of phantom limb pain includes the use of perineural infusion (continuous peripheral nerve blocks). Patients receiving this intervention reported an average Phantom Limb Pain intensity of 3.0 to 4.5 on the Numeric Rating Scale four weeks after initiation 2.

In addition to pain reduction, patients undergoing perineural infusion showed varied outcomes in physical and emotional functioning as measured by the Brief Pain Inventory Interference Domain (ranging from 0 to 28) and Beck Depression Inventory scores (ranging from 6 to 13) at the four-week mark 2.

Recent results — preliminary, needs further review

  • Active cryoneurolysis is currently being evaluated for phantom limb pain 1.

For the clinician treating this condition

  • Perineural infusion (continuous peripheral nerve block) is an established intervention that can reduce phantom limb pain intensity and impact functional scores at 4 weeks post-initiation.
  • Cryoneurolysis represents a recent, emerging intervention for this condition.

AI synthesis of 2 cited trials, updated Jun 29, 2026. Informational only — not medical advice; trial data sourced from ClinicalTrials.gov. How we use AI.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Systematic review of percutaneous ablation for residual and phantom limb pain after amputation
Physical Medicine & Rehab Meta-analysis
Systematic review of percutaneous ablation for residual and phantom limb pain after amputation Heat Therapy Stops Amputation Pain
This systematic review evaluated thermal radiofrequency ablation (RFA), pulsed RFA, and cryoablation for residual limb pain (RLP) and phanto…
Heat therapy stops the burning, aching pain felt in the space where an amputated limb used to be, offering relief where standard drugs often…
Frontiers Apr 15, 2026
Antibiotic duration and type associated with chronic post-amputation pain in military cohort
Anesthesiology & Pain Medicine Cohort
Antibiotic duration and type associated with chronic post-amputation pain in military cohort Study finds link between antibiotic use and chronic pain after traumatic amputation
A retrospective cohort study of 212 military personnel with traumatic amputations found prolonged antibiotic use (>21 days) and combined reg…
Using antibiotics for more than 21 days or taking two or more types together increased the risk of chronic pain after traumatic amputation i…
Frontiers Apr 3, 2026