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Home › Medications › normal saline

normal saline

4 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials of normal saline

151 trials tracked of normal saline: 75 in phase 3 or 4 and 19 with published results. The most-cited published study has 2302 citations.

151Trials tracked
75Phase 3 & 4
0Recruiting
19With published results
Phase distribution
Phase 4 39 Phase 3 36 Phase 2 40 Phase 1 9 Other / NA 27
  1. Phase 4 Intravenous Dexmedetomidine for Cesarean Section Completed · 2,302 cited
  2. Phase 4 The CHECK Trial: A Comparison of Headache Treatment in the ED: Compazine Versus Ketamine Completed · 559 cited
  3. Phase 3 Ascorbic Acid, Corticosteroids, and Thiamine in Sepsis (ACTS) Trial Completed · 253 cited
  4. Phase 4 Biomarker Assessment of Glutamatergic Target Engagement Completed · 104 cited
  5. Phase 3 Lactated Ringers With or Without Rectal Indomethacin to Prevent Post-ERCP Pancreatitis Completed · 95 cited
  6. Phase 4 Tranexamic Acid (TXA) Versus Epsilon Aminocaproic Acid (EACA) Versus Placebo for Spine Surgery Completed · 65 cited
Show 44 more trials
  1. Phase 4 Ropivacaine Block Alone or With Perineural or Systemic Dexamethasone for Pain in Shoulder Surgery Completed · 65 cited
  2. Phase 3 Naloxone for Optimizing Hypoxemia Of Lung Donors Completed · 23 cited
  3. Phase 4 Evaluation of Dexmedetomidine on Post-operative Narcotic Requirements and Pain Scores in Bariatric Patients Completed · 21 cited
  4. Phase 4 OnabotulinumtoxinA (BOTOX®) Treatment for Urinary Incontinence in Patients With Overactive Bladder Completed · 18 cited
  5. Phase 4 Does IV Acetaminophen Reduce Opioid Requirement in Pediatric Patients With Acute Sickle Cell Crises? Completed · 16 cited
  6. Phase 3 Metoclopramide for Post Traumatic Headache Completed · 16 cited
  7. Phase 4 Multimodal Pain Management for Cesarean Delivery Completed · 14 cited
  8. Phase 3 Pediatric Tonsillectomy Pain Reduction Study Completed · 13 cited
  9. Phase 3 The Use of Intraperitoneal Ropivacaine in Bariatric Bypass Surgery Completed · 12 cited
  10. Phase 3 Furosemide and Albumin for Diuresis of Edema: A Pilot Randomized Controlled Trial Completed · 10 cited
  11. Phase 3 Comparing TAP Blocks Bupivacaine, and Placebo for Plane Completed · 8 cited
  12. Phase 3 Ketamine for Postoperative Avoidance of Depressive Symptoms: The K-PASS Feasibility Trial Completed · 5 cited
  13. Phase 4 Prophylactic Antibiotics in Admitted Cirrhotics Completed · 4 cited
  14. Phase 4 Intranasal Fentanyl for Initial Treatment of a Vaso-occlusive Crisis Completed
  15. Phase 4 Low Doses of Ketamine and Postoperative Quality of Recovery Completed
  16. Phase 4 Corticosteroid/Ropivacaine Versus Corticosteroid/Saline Injections for Knee Osteoarthritis Completed
  17. Phase 4 The Combination of Adductor Canal Block and Periarticular Injection. A Novel Technique for Patients Undergoing Total Knee Replacement (ACB PAI) Completed
  18. Phase 4 Combined Administration of Nebulized Amikacin in Patients With Acute Exacerbation of Non-Cystic Fibrosis Bronchiectasis Completed
  19. Phase 4 Efficacy of Tranexamic Acid in Foot and Ankle Surgeries Completed
  20. Phase 4 Topical Tranexamic Acid (TXA) in Joint Arthroplasty Completed
  21. Phase 4 Hyperosmolar Saline Irrigation Fluid in Arthroscopic Knee Surgery Completed
  22. Phase 4 Use of On-Q Pump for Pain Post C-Section Completed
  23. Phase 4 A Trial Comparing Single Intra-op Dose of Methadone Versus Placebo in Patients Undergoing Spine Surgery Completed
  24. Phase 4 Low Dose Ketamine as an Adjunct to Opiates for Acute Pain in the Emergency Department Completed
  25. Phase 4 Peri-operative Use of a Pain Injection in Pediatric Patients With Cerebral Palsy Completed
  26. Phase 4 Dosage of Epidural Morphine in Elderly Patients Completed
  27. Phase 4 Mepolizumab for the Treatment of Chronic Cough With Eosinophilic Airways Diseases Completed
  28. Phase 4 Efficacy of Intra-articular Collagen Injection in Patients With Knee Joint Pain Compared to Normal Saline Injection Completed
  29. Phase 4 Comparing Outcomes for Prontosan Versus Normal Saline for Negative Pressure Wound Therapy With Instillation Completed
  30. Phase 4 Usefulness of Dexmedetomidine on Post-operative Pain Management in Patients With Interstitial Cystitis Completed
  31. Phase 4 Effects of Epidural Local Anesthetics on Propofol Induction Completed
  32. Phase 4 Effect of Nafamostat on Postreperfusion Syndrome (PRS) Completed
  33. Phase 4 Regimen of Alfentanil in Propofol Sedative Fibro-bronchoscopy Completed
  34. Phase 4 Greater Occipital Nerve Block for Migraine Prophylaxis Completed
  35. Phase 4 Symptomatic Relief of Acute Dyspeptic Pain in Emergency Department With Pantoprazole Completed
  36. Phase 4 Efficacy of IV Lidocaine at Alleviating Pain Associated With Propofol Infusion in Pediatric Patients Undergoing Sedation Completed
  37. Phase 4 Low Dose Ketamine Study on Opioid Tolerance and Hyperalgesia Completed
  38. Phase 4 A Study of Subject Satisfaction With BOTOX® Cosmetic Treatment in Facial Rhytides Completed
  39. Phase 4 Control of Tourniquet Pain With an Axillary Ring of Subcutaneous Local Anesthetic Completed
  40. Phase 4 Infrapatellar Nerve Block for Post-operative Knee Arthroscopy Pain Control Completed
  41. Phase 4 The Impact of Pain Scores on Intrauterine Lidocaine Versus Normal Saline Infusion at the Time of IUD Placement Completed
  42. Phase 4 Randomized Study of Caspofungin Prophylaxis Followed by Pre-emptive Therapy for Invasive Candidiasis in the Intensive Care Unit (ICU) Completed
  43. Phase 3 Use of Artefill® for Moderate to Severe Atrophic Acne Scar Correction Completed
  44. Phase 3 A Safety and Efficacy Study of OnabotulinumtoxinA in Forehead and Glabellar Facial Rhytides Completed

Showing the 50 most-cited and recently-updated of 151 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Balanced crystalloid solutions reduce mortality and acute kidney injury in adult patients with sepsis
Rheumatology Meta-analysis
Balanced crystalloid solutions reduce mortality and acute kidney injury in adult patients with sepsis Balanced crystalloid solutions show lower death rates in sepsis patients
This meta-analysis of 7 trials involving 8,173 adults with sepsis found that balanced crystalloids significantly reduced mortality (RR 0.92)…
A large review of over 8,000 patients suggests balanced crystalloid fluids may reduce mortality and kidney damage for those with sepsis.
Frontiers Aug 21, 2026
Normal saline tract instillation reduces pneumothorax and chest tube requirements during CT-guided lung biopsy
Radiology & Imaging Meta-analysis
Normal saline tract instillation reduces pneumothorax and chest tube requirements during CT-guided lung biopsy Saline trick cuts lung biopsy complication risk
Researchers evaluated the impact of normal saline tract instillation on complications following CT-guided lung biopsies. The analysis found …
A simple saline rinse during lung biopsy may cut the risk of lung collapse and chest tube placement, new analysis finds.
Aug 5, 2026
Intravenous dexmedetomidine improves sleep quality scores in women after elective cesarean section
Orthopedics & Sports Medicine RCT
Intravenous dexmedetomidine improves sleep quality scores in women after elective cesarean section A single dose of dexmedetomidine improved sleep for women after elective cesarean section
This randomized controlled trial enrolled 68 women undergoing elective cesarean section.
Women who received a specific medicine infusion slept better in the first few days after having an elective cesarean section.
Frontiers May 1, 2026
L9LS monoclonal antibody reduces malaria infection in children in western Kenya
Pediatrics RCT
L9LS monoclonal antibody reduces malaria infection in children in western Kenya A malaria shot for babies shows real protection in Kenya
This randomized controlled trial evaluated the L9LS monoclonal antibody in infants and children in a high perennial malaria transmission set…
A long-acting antibody shot reduced malaria infections by 43% in young children in Kenya, with no major safety concerns.
Apr 27, 2026