Phase 2 N=73 Cognitive Stimulation
Substance Use Disorders
Primary: Working Memory — 0.86; 0.04 digits recalled
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
N/A N=49 Cognitive Dysfunction in Parkinson's Disease
Parkinson's Disease
Primary: Change in Magnetoencephalography (MEG) Connectivity Measures
N/A N=75 Cognitive Behavior Therapy and Work Outcome
Schizophrenia
Primary: Work Quality — 3.01; 3.23; 3.33 scores on a scale
N/A N=20 Electrophysiologic Studies of Cognition in Epilepsy Patients
Drug-resistant Epilepsy
Primary: Heartbeat Evoked Potential (HEP) for Attention — -1.5 µV
N/A N=35 Neural Bases of Cognitive Rehabilitation for Brain Injury
Brain Injury
Primary: Change From Baseline on a Composite Measure (Z-score) of Attention, Working Memory, and Executive Functions — 0.26; .01 Change to Z (composite) score
Early Phase 1 N=124 Boost Study 21270 (Cognition)
Cognitive Function Abnormal
Primary: Task Completion Rate — 66; 57 Percentage of eligible participants
N/A N=95 Cognitive Dysfunction In Parkinson's
Parkinson's
Primary: Differences in Error Rates on the NBack Task Between Real and Sham Stimulation Trials — -0.79; -0.1 incorrect responses
N/A N=60 Cognitive Markers in Prodromal MS
Multiple Sclerosis
Primary: Cerebral Metabolic Rate of Oxygen (CMRO2) — 8.17 micro-mol/100g/min
Phase 4 N=60 Characterizing and Predicting Drug Effects on Cognition
Cognitive Deficits
Primary: Change From Baseline in COWA Unique Word Count — -0.407725385; -0.425898667; -0.412534118; -0.108298333 Word Count
N/A N=121 Cognition Intervention Study Dortmund
Cognition - Other
Primary: Tonic Alertness (Mean Reaction Time) — 281; 279 Milliseconds — p=0.79
Phase 3 N=1,498 Cognition in the Study of Tamoxifen and Raloxifene
Cognition · Aging
Primary: Mean Change From Baseline on the the Benton Visual Retention Test Scores by Treatment Group — -0.73; -1.41 Number of errors
N/A N=110 Cognition and Psychotherapy in PTSD
Posttraumatic Stress Disorder (PTSD)
Primary: Change in PTSD Checklist (PCL-5) — 9.25; 11.94; 15.91 change in units on a scale
N/A N=9 Genetic and Neural Factors in Alcohol-Related Cognition
Alcohol Abuse
Primary: Changes in Alcohol-influenced Behavior — 1.56; 1.49 units on a scale
N/A N=26 Brain Stimulation and Enhancing Cognition in Older Adults
Cognitive Impairment, Mild · Depressive Symptoms · Anxiety
Primary: Cognitive and Memory Function — 56.5; 49.8 score on a scale
N/A N=36 Brain Function and Decision-Making
Behavior, Social · Psychology, Social · Social Interaction
Primary: Change in Prefrontal Cortex Brain Activity Assessed by fMRI — -0.002; 0.015 Percent BOLD Signal Change
N/A N=6 Cognitive Rehab for Parkinson's
Parkinson's Disease · Mild Cognitive Impairment
Primary: Change in NIH Sponsored Executive Abilities: Measures and Instruments for Neurobehavioral Evaluation and Research (NIH-EXAMINER) Executive Composite Score — 0.34; -.42…
N/A N=153 Social Cognition Intervention
Psychosis
Primary: Mayer-Salovey-Caruso Emotional Intelligence Test (MSCEIT) — 87.30; 87.30; 88.46; 89.23 units on a scale — p=< .05
N/A N=287 Examining the Effectiveness of Cognitive Training
Cognitive Change
Primary: Proportion of Correct Targets Identified Minus False Identifications in the n-Back Task — .80; .70; .68; .21 score on a scale
N/A N=51 Efficacy of Social Cognition Training in Schizophrenia
Schizophrenia
Primary: Social Cognitive Measures — 0.11; -1.68 score on a scale
Phase 4 N=53 Treating Cognition in Schizophrenia With Atomoxetine and Cognitive Remediation
Cognition in Schizophrenia
Primary: Neuropsychological Measures for MATRICS — 20.82; 18.03; 25.43; 11.64 score on a scale
N/A N=69 Cognitive Training for Patients With Schizophrenia
Schizophrenia · Schizoaffective Disorder · Other Primary Psychotic Disorders
Primary: UCSD Performance-based Skills Assessment Total Score (Measures Functional Capacity) — 82.7; 84.4 units on a scale
Phase 4 N=121 Emotional and Cognitive Control in Late-Onset Depression
Depression
Primary: Change in Depression Severity (Measured by Montgomery Asberg Depression Rating Scale) — 25.26; 1.03; 13.78; 1.08 score on a scale — p=< 0.025
N/A N=40 Preventing Cognitive Decline
Cognitive Decline
Primary: Percentage of Trials Correct On Working Memory Test — 87.69; 91.57; 88.01; 91.68 percentage of correct trials — p=>0.05
N/A N=22 Brain and Cognitive Changes After Reasoning Training in Individuals With Mild Cognitive Impairment
Mild Cognitive Impairment
Primary: Change From Baseline in California Verbal Learning Task Score — 3.04; 5.17; 4.22; 7.04 score on a scale
N/A N=37 Effectiveness of Cognitive Remediation in a Supported Education Setting
Psychosis
Primary: Completion of Academic Semesters — 1.95; 1.67; 1.89; 1.67 Courses completed — p=0.029
Early Phase 1 N=10 Cognition, Age, and RaPamycin Effectiveness - DownregulatIon of thE mTor Pathway
Cognitive Impairment, Mild · Alzheimer Disease
Primary: Blood Brain Barrier Penetration of RAPA — 0 ng/ml
N/A N=59 Cognitive Rehabilitation in Schizophrenia
Cognitive Impairment · Schizophrenia
Primary: Wisconsin Card Sort Percent Perseverative Errors (Standard Score) — 87.54; 87.88; 91.80 standard score units — p=<.97
N/A N=12 Brain Stimulation and Cognitive Training
Bipolar Disorder · Schizo Affective Disorder · Schizophrenia
Primary: Participant Retention in Combination Treatment — 4; 5 Participants
N/A N=15 Brain Stimulation and Cognitive Training - Efficacy
Schizophrenia · Schizo Affective Disorder · Bipolar Disorder
Primary: Change in Working Memory Performance - Measurement and Treatment Research to Improve Cognition in Schizophrenia (MATRICS) Consensus Cognitive Battery (MCCB)…
N/A N=241 Cognition and Smoking Relapse (HCS)
Smoking Cessation
Primary: Cognitive Function — 0.125; -.093; -.059; -.008 z-score