N/A N=95 Cognitive Dysfunction In Parkinson's
Parkinson's
Primary: Differences in Error Rates on the NBack Task Between Real and Sham Stimulation Trials — -0.79; -0.1 incorrect responses
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
N/A N=35 Neural Bases of Cognitive Rehabilitation for Brain Injury
Brain Injury
Primary: Change From Baseline on a Composite Measure (Z-score) of Attention, Working Memory, and Executive Functions — 0.26; .01 Change to Z (composite) score
N/A N=49 Cognitive Dysfunction in Parkinson's Disease
Parkinson's Disease
Primary: Change in Magnetoencephalography (MEG) Connectivity Measures
Phase 2 N=4 Enhancing Attention in Adults With Compulsive Hoarding
Hoarding Disorder
Primary: Number of Patients Who Met and Exceeded Response Criteria of Attention Deficit Hyperactivity Disorder Symptom Scale — 4 participants
Phase 4 N=60 Characterizing and Predicting Drug Effects on Cognition
Cognitive Deficits
Primary: Change From Baseline in COWA Unique Word Count — -0.407725385; -0.425898667; -0.412534118; -0.108298333 Word Count
Phase 3 N=61 Effects of Dalfampridine on Cognition in Multiple Sclerosis
Multiple Sclerosis
Primary: Symbol Digit Modalities Test — 41.18; 35.06; 45.05; 38.63 score on a scale
N/A N=10 Transcranial Direct Current Stimulation (tDCS)
Brain Fog
Primary: Perceived Ease of Use After 4 Weeks of Daily tDCS Use (TAM Score) — 30.5 units on a scale
N/A N=110 Cognition and Psychotherapy in PTSD
Posttraumatic Stress Disorder (PTSD)
Primary: Change in PTSD Checklist (PCL-5) — 9.25; 11.94; 15.91 change in units on a scale
N/A N=69 Cognitive Training for Patients With Schizophrenia
Schizophrenia · Schizoaffective Disorder · Other Primary Psychotic Disorders
Primary: UCSD Performance-based Skills Assessment Total Score (Measures Functional Capacity) — 82.7; 84.4 units on a scale
N/A N=21 Assessment and Treatment of Cognitive Functioning Deficits in Veterans With PTSD
Posttraumatic Stress Disorder
Primary: Prospective-Retrospective Memory Questionnaire (PRMQ; Crawford et al., 2006) — 50.38; 38.5; 47.875; 42.5 score on a scale
N/A N=46 Targeting Self-regulatory Deficits Through Cognitive Remediation Intervention
Drug Use Disorders
Primary: Change in Stop Signal Reaction Time — -8.62 ms — p=.003
N/A N=59 Cognitive Rehabilitation in Schizophrenia
Cognitive Impairment · Schizophrenia
Primary: Wisconsin Card Sort Percent Perseverative Errors (Standard Score) — 87.54; 87.88; 91.80 standard score units — p=<.97
Phase 2 N=63 Treatment Study for Cognitive Deficits in Schizophrenia
Schizophrenia
Primary: Composite MATRICS Consensus Cognitive Battery Score — 27.9; 31.3; 32.5 composite score — p=0.21
N/A N=112 Semantic Learning Deficits in School Age Children With Developmental Language Disorder
Developmental Language Disorder
Primary: Mean Percent Correct Semantic Meaning Identification — 73.6; 75.12; 77.1; 82.3 percentage of correct responses — p=0.36
N/A N=268 Cognitive Rehabilitation for Gulf War Illness
Gulf War Illness
Primary: Disability - WHO-DAS 2 Change — -2.81; -2.21 score on a scale — p=0.712
N/A N=85 Improving Basic and Social Cognition in Veterans With Schizophrenia
Schizoaffective Disorder · Schizophrenia
Primary: Mean Test Scores for Facial Emotion Identification. — 45.5; 41.1; 43.8; 45.1 number of correct answers — p=<.001
N/A N=89 Impact of Hyperarousal on Simple and Complex Cognitive Task Performance Among Insomnia Sufferers
Insomnia · Primary Insomnia · Chronic Insomnia
Primary: Number of Incorrect Trials During the Computer-administered Attention-Switching Task Test.Attention-Switching Task Latency Error Rate — 5.11; 3.1 trials
N/A N=110 Cognitive Rehabilitation for PD
Parkinson's Disease
Primary: Wechsler Adult Intelligence Scale-IV (WAIS-IV) Matrix Reasoning Test Total Scaled Score — 0.22; 0.42 score on a scale — p=0.6662
N/A N=251 Cognitive Problems in Veterans With Heart Failure
Heart Failure · Cognition Disorders
Primary: SLUMS Scores — 24.39 scores on a scale
Phase 1 N=52 Behavioral and Neuroimaging Changes After Cognitive Rehab in Traumatic Brain Injuries (TBI) and Mild Cognitive Impairment (MCI)
Mild Cognitive Impairment · Alzheimer's Disease · Traumatic Brain Injury
Primary: Memory Test Accuracy on Trained Stimuli — 53.9; 37.6; 48.9; 37.3 Percent correct
Phase 4 N=33 Modafinil for Treatment of Cognitive Dysfunction in Schizophrenia
Schizophrenia · Schizoaffective Disorder
Primary: Percent Change in Accuracy on High-control (i.e., Difficult) Condition of Preparing to Overcome Prepotency Task — 8.6; 9.2 percent change in accuracy
N/A N=78 Semantic Memory, Financial Capacity, and Brain Perfusion in Mild Cognitive Impairment (MCI) (CASL)
Alzheimer Disease · Dementia
Primary: FCI Score at Follow-up — 147.3; 164.0; 123.3; 150.8 points awarded for correct items
Phase 4 N=29 Modafinil Effects on Cognition in Schizophrenia Patients
Schizophrenia
Primary: Cognitive Performance — 76.7; 75.5; 67.2; 77.1 percentage correct of all trials
N/A N=59 Cognitive Training in the Treatment of AUD
Alcohol Use Disorder Cognitive Decline
Primary: Days of Heavy Alcohol Use Assessed by Weekly Time Line Follow-back and Breathalyzer — 5.49; 3.0 Days — p=<.05
Phase 2 N=73 Cognitive Stimulation
Substance Use Disorders
Primary: Working Memory — 0.86; 0.04 digits recalled
Phase 4 N=63 Targeting Cognition in Bipolar Disorder With Pramipexole
Bipolar Disorder
Primary: MATRICS Consensus Cognitive Battery — 35.45; 38.07 T-score — p=0.38
Phase 4 N=60 The Effects of Nicotine on Cognition in Schizophrenia
Schizophrenia
Primary: Effects of Nicotine Patch Compared With Placebo in Non- Smokers With Schizophrenia and Control Groups on Attention Measured by the Continuous Performance Test Identical…
N/A N=146 Cognitive Training and Practice Effects in Mild Cognitive Impairment
Mild Cognitive Impairment
Primary: Auditory Memory Attention Index — 89.0; 94.3 standard score units — p=<0.01
N/A N=72 Treatment to Enhance Cognition in Bipolar Disorder
Bipolar Disorder · Psychosis
Primary: MATRICS Consensus Cognitive Battery (MCCB) — 45.2; 45.5; 47.7; 49.3 T-scores
N/A N=145 Cognitive Rehabilitation Therapy for Mild Cognitive Impairment
Mild Cognitive Impairment
Primary: Change in Objective Cognitive Performance Composite z Score — .24; .14 Z score