Etalanetug reduces CSF tau biomarkers in dominantly inherited Alzheimer's disease in phase 1b/2 study
Can a new drug slow Alzheimer's toxic tau protein in the brain?
This open-label phase 1b/2 study in 8 participants with mild-to-moderate cognitive impairment due to dominantly inherited Alzheimer's diseas…
An early study shows an experimental drug lowers two key tau proteins in spinal fluid for people with a rare inherited form of Alzheimer's.
Plasma biomarkers diverge sequentially up to 26 years before symptom onset in autosomal dominant Alzheimer's disease
Can a blood test spot Alzheimer's risk decades before symptoms appear?
A longitudinal cohort study of 73 ADAD mutation carriers and 40 non-carriers found eight plasma biomarkers elevated sequentially from 26 to …
A blood test can spot Alzheimer's risk up to 26 years before symptoms appear in people with a specific inherited gene mutation.
CSF protein changes in autosomal dominant Alzheimer's disease show inflammatory markers follow amyloid and tau abnormalities
Study maps protein changes in inherited Alzheimer's disease before symptoms appear
An observational study of 484 participants with pathogenic PSEN1, PSEN2, and APP mutations from the DIAN network analyzed 972 CSF samples.
Inherited Alzheimer's shows inflammation and brain damage appearing after amyloid and tau changes, proving a multi-protein test predicts sym…
Research across Alzheimer's Disease
Related studies from across the Alzheimer's Disease family.
Rapid advancements in imaging and blood-based biomarkers are transforming the diagnosis and management of ADRD
New guidelines help doctors tell delirium from dementia
This clinical guideline provides a narrative review on the evolving diagnostic and treatment landscape for Alzheimer's disease and related d…
Delirium is acute and fluctuating; dementia is chronic. New guidelines help doctors tell them apart.
MIND diet shows greater cognitive improvement in community-dwelling adults with high biomarker levels over three years
MIND diet linked to better brain health in older adults with high biomarkers
In a randomized clinical trial, the MIND diet demonstrated superior longitudinal cognitive outcomes compared to a control diet among older a…
Older adults on the MIND diet showed greater cognitive improvement than controls when they had higher levels of specific brain biomarkers.
Periodontal disease is associated with a 2.67 odds ratio for Alzheimer's disease
Gum disease linked to higher Alzheimer's risk in large analysis
This meta-analysis of 291,057 participants identified a significant association between periodontal disease and Alzheimer's disease (OR = 2.…
A large analysis of 291,057 people found that gum disease is linked to nearly 3 times higher odds of Alzheimer's disease, but more research …
Extended occupational therapy showed no significant improvement in behavioral symptoms for dementia patients
Extended occupational therapy shows no added benefit for dementia
This randomized controlled trial evaluated community-dwelling adults with mild-to-moderate dementia in France. Participants received occupat…
Adding four more months of occupational therapy did not improve behavioral symptoms in people with mild-to-moderate dementia, compared to st…
Regulatory suspension prohibits DCLVA use for Alzheimer's disease due to unresolved physiological uncertainties and scientific gaps
Regulatory suspension blocks use of DCLVA for Alzheimer's disease
This narrative review examines the potential of deep cervical lymphaticovenous anastomosis (DCLVA) for patients with Alzheimer's disease. Th…
A regulatory suspension currently prohibits using Deep cervical lymphaticovenous anastomosis for Alzheimer's disease because major scientifi…
Obesity in older adults lowers Alzheimer's risk while underweight status and weight loss increase it
Obesity protects older adults from Alzheimer's risk, but not younger ones
This systematic review and meta-analysis examined thirty-eight studies on anthropometric measures in individuals with Alzheimer's disease ri…
A meta-analysis of thirty-eight studies found that obesity lowers Alzheimer's risk in people over sixty, while increasing risk in those unde…
GLP-1 receptor agonists may reduce cognitive decline in type 2 diabetes patients with dementia
GLP-1 drugs may slow cognitive decline in type 2 diabetes
A systematic review of systematic reviews and meta-analyses found that GLP-1 receptor agonists are associated with reduced overall cognitive…
A review of reviews suggests GLP-1 drugs like Ozempic may help protect memory and thinking in people with type 2 diabetes.
Ceramides emerge as key players in Alzheimer's pathology but therapeutic targeting faces hurdles
Ceramides may help Alzheimer's but brain barriers and safety remain unclear
This narrative review examines the role of ceramides in Alzheimer's disease, highlighting their involvement in neural and immune homeostasis…
A review suggests ceramides could support brain health in Alzheimer's, yet blood-brain barriers and safety concerns limit current use.
Meta-analysis identifies 311 serum metabolite associations in Alzheimer's disease trajectory
New blood tests reveal how Alzheimer's changes your body over seven years
This meta-analysis of 1,430 ADNI participants identified 311 significant serum metabolite associations across 15 Alzheimer's disease phenoty…
A seven-year study found that specific chemicals in your blood change over time as Alzheimer's disease progresses, offering new clues about …
HMC3 microglial model illuminates neurodegenerative mechanisms and early therapeutic discovery
New tool helps scientists study brain cell stress in Alzheimer's and Parkinson's disease
This narrative review synthesizes experimental evidence from HMC3 human microglial cell line and co-culture systems to explore mechanisms in…
Scientists use a special human brain cell line to study stress and cell death in diseases like Alzheimer's and Parkinson's, offering a new w…
TREM2 activation lowers amyloid plaques and tau in Alzheimer's disease animal models across twelve studies
Boosting TREM2 activity helps clear brain plaques and improves memory in mouse models of Alzheimer's disease
A systematic review and meta-analysis of twelve preclinical studies shows TREM2 overexpression or agonist antibodies significantly reduce am…
A review of twelve studies shows that increasing TREM2 activity reduces harmful brain proteins and fixes memory loss in mice. This suggests …
Acupuncture Boosts Cognition in Alzheimer's and Mild Cognitive Impairment
Meta-analysis shows acupuncture improves cognitive function in Alzheimer's and mild cognitive impairment
A meta-analysis of 3362 patients finds acupuncture, alone or with Western medicine, significantly improves cognitive function in Alzheimer's…
A large analysis of 3,362 patients suggests acupuncture may improve cognitive function in Alzheimer's disease and mild cognitive impairment,…