Etalanetug reduces CSF tau biomarkers in dominantly inherited Alzheimer's disease in phase 1b/2 study
Can a new drug slow Alzheimer's toxic tau protein in the brain?
This open-label phase 1b/2 study in 8 participants with mild-to-moderate cognitive impairment due to dominantly inherited Alzheimer's diseas…
An early study shows an experimental drug lowers two key tau proteins in spinal fluid for people with a rare inherited form of Alzheimer's.
Plasma biomarkers diverge sequentially up to 26 years before symptom onset in autosomal dominant Alzheimer's disease
Can a blood test spot Alzheimer's risk decades before symptoms appear?
A longitudinal cohort study of 73 ADAD mutation carriers and 40 non-carriers found eight plasma biomarkers elevated sequentially from 26 to …
A blood test can spot Alzheimer's risk up to 26 years before symptoms appear in people with a specific inherited gene mutation.
CSF protein changes in autosomal dominant Alzheimer's disease show inflammatory markers follow amyloid and tau abnormalities
Study maps protein changes in inherited Alzheimer's disease before symptoms appear
An observational study of 484 participants with pathogenic PSEN1, PSEN2, and APP mutations from the DIAN network analyzed 972 CSF samples.
Inherited Alzheimer's shows inflammation and brain damage appearing after amyloid and tau changes, proving a multi-protein test predicts sym…
Research across Alzheimer's Disease
Related studies from across the Alzheimer's Disease family.
Sleep and circadian disturbances characterize behavioral patterns and physiology in patients with Alzheimer disease
Sleep and Circadian Disturbances Impact Patients with Alzheimer's Disease
This narrative review explores how sleep and circadian disturbances impact patients with Alzheimer disease. It synthesizes findings on behav…
Understanding how sleep patterns and internal body clocks affect those with Alzheimer's disease can help identify key areas for clinical car…
Gut microbiota-associated signals may influence immune homeostasis and neuroinflammation in neurodegenerative diseases
Gut bacteria may influence immune health in the central nervous system
This systematic review explores how gut microbiota-associated signals, including short-chain fatty acids and bile acids, may influence immun…
Gut bacteria and their byproducts may influence immune responses and inflammation in the brain, potentially impacting several neurodegenerat…
Amyloid and tau pathology in the biomarker-detectable range occurred in 19.6% of decedents
Study links specific brain protein patterns to Alzheimer disease progression
This cross-sectional clinicopathologic study of 2,711 decedents analyzed the relationship between amyloid and tau pathology and cognitive im…
New research shows that specific combinations of amyloid and tau proteins in the brain are linked to the progression of Alzheimer disease sy…
Gut-Brain Homeostatic Continuum framework proposes a multi-layered system for understanding Alzheimer disease pathogenesis
New Framework Suggests Gut Health Links to Alzheimer's Disease
This narrative review introduces the Gut-Brain Homeostatic Continuum (GBHC) as a conceptual framework for Alzheimer disease. It frames the d…
A new conceptual framework suggests Alzheimer's disease may involve a breakdown in the complex balance between gut health and brain function…
Epidemiological studies report a modest bidirectional inverse association between cancer and Alzheimer disease
Understanding the Complex Link Between Cancer and Alzheimer's Disease Progression
This mini review examines the epidemiological and preclinical links between cancer and Alzheimer disease. It identifies a modest inverse ass…
New research looks at why some people with cancer show a lower risk of dementia. Scientists are studying the complex link between these cond…
Photobiomodulation shows consistent anti-inflammatory effects but inconsistent clinical results in various neurodegenerative disorders
Red and near-infrared light may help certain brain disorders
This narrative review explores the role of photobiomodulation in treating Alzheimer's disease, Multiple Sclerosis, Parkinson's disease, and …
Red and near-infrared light therapy shows promise for some brain conditions, though results are mixed for others.
Diabetic Retinopathy Tied to Higher Dementia Incidence in Pooled Analysis
Diabetes eye damage may link to higher risk of dementia
Pooled data from nearly 3 million patients link diabetic retinopathy to higher incident dementia, though crude analyses show no significant …
A large study of over 2 million people suggests that eye damage from diabetes is linked to a higher risk of developing dementia.
Luteolin monotherapy improves cognitive and memory impairments in rodent models of Alzheimer disease
Luteolin may improve memory and brain health in rodent models
This meta-analysis of preclinical rodent models indicates that luteolin monotherapy significantly ameliorates cognitive and memory impairmen…
A review of research suggests the compound luteolin could protect memory and reduce brain inflammation in models of Alzheimer's disease.
AI-driven MRI analysis shows potential for automated feature extraction and objective prediction in Alzheimer disease
Artificial intelligence helps doctors find signs of Alzheimer's disease
This systematic review evaluates the role of artificial intelligence, including deep learning and machine learning, in MRI analysis for Alzh…
New tools use artificial intelligence to spot subtle patterns in brain scans that might help catch Alzheimer's disease earlier.
Multidomain lifestyle intervention provides cognitive benefits regardless of baseline p-tau217 levels in older adults
Lifestyle changes may help those at risk of Alzheimer's disease
This secondary analysis of a randomized controlled trial involving 1260 older adults at risk of dementia found that a multidomain lifestyle …
A study of over 1,200 older adults shows that lifestyle changes can provide cognitive benefits regardless of certain blood markers.
Structured assessment is needed to distinguish traumatic brain injury sequelae from independent Alzheimer disease
Distinguishing brain injury effects from Alzheimer's disease progression
This narrative review explores the complexities of managing cognitive decline in patients with a history of traumatic brain injury. The auth…
Doctors are working to tell the difference between cognitive decline caused by old brain injuries and the start of Alzheimer's disease.
Protein glycosylation and glycation drive amyloid aggregation and neuroinflammation in Alzheimer disease
New research identifies how sugar and protein changes impact Alzheimer's
This systematic review examines how protein glycosylation and glycation contribute to Alzheimer disease pathology. The authors conclude that…
Scientists have identified how specific chemical changes to proteins and sugars may drive Alzheimer's disease and offer paths for earlier di…