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Neurology
Cohort
Plasma biomarkers diverge sequentially up to 26 years before symptom onset in autosomal dominant Alzheimer's disease
Can a blood test spot Alzheimer's risk decades before symptoms appear?
A longitudinal cohort study of 73 ADAD mutation carriers and 40 non-carriers found eight plasma biomarkers elevated sequentially from 26 to …
A blood test can spot Alzheimer's risk up to 26 years before symptoms appear in people with a specific inherited gene mutation.
medRxiv
Apr 6, 2026
Neurology
CSF protein changes in autosomal dominant Alzheimer's disease show inflammatory markers follow amyloid and tau abnormalities
Study maps protein changes in inherited Alzheimer's disease before symptoms appear
An observational study of 484 participants with pathogenic PSEN1, PSEN2, and APP mutations from the DIAN network analyzed 972 CSF samples. K…
Inherited Alzheimer's shows inflammation and brain damage appearing after amyloid and tau changes, proving a multi-protein test predicts sym…
medRxiv
Apr 4, 2026