Etalanetug reduces CSF tau biomarkers in dominantly inherited Alzheimer's disease in phase 1b/2 study
Can a new drug slow Alzheimer's toxic tau protein in the brain?
This open-label phase 1b/2 study in 8 participants with mild-to-moderate cognitive impairment due to dominantly inherited Alzheimer's diseas…
An early study shows an experimental drug lowers two key tau proteins in spinal fluid for people with a rare inherited form of Alzheimer's.
Plasma biomarkers diverge sequentially up to 26 years before symptom onset in autosomal dominant Alzheimer's disease
Can a blood test spot Alzheimer's risk decades before symptoms appear?
A longitudinal cohort study of 73 ADAD mutation carriers and 40 non-carriers found eight plasma biomarkers elevated sequentially from 26 to …
A blood test can spot Alzheimer's risk up to 26 years before symptoms appear in people with a specific inherited gene mutation.
CSF protein changes in autosomal dominant Alzheimer's disease show inflammatory markers follow amyloid and tau abnormalities
Study maps protein changes in inherited Alzheimer's disease before symptoms appear
An observational study of 484 participants with pathogenic PSEN1, PSEN2, and APP mutations from the DIAN network analyzed 972 CSF samples.
Inherited Alzheimer's shows inflammation and brain damage appearing after amyloid and tau changes, proving a multi-protein test predicts sym…
Research across Alzheimer's Disease
Related studies from across the Alzheimer's Disease family.
Transcranial pulse stimulation improves MMSE and MoCA scores in patients with Alzheimer's disease
Different brain stimulation methods show specific benefits for Alzheimer's
This network meta-analysis of 1,445 patients evaluated various neuromodulation techniques for Alzheimer's disease. The analysis found that t…
New research shows that different types of brain stimulation can improve specific symptoms of Alzheimer's, from memory to daily activities.
Platelet-rich plasma shows potential for tissue repair and functional recovery in various nerve injuries
Platelet-rich plasma shows potential for nerve and brain repair
This systematic review evaluates the preclinical potential of platelet-rich plasma (PRP) for treating spinal cord, sciatic, and facial nerve…
Platelet-rich plasma may help repair nerve damage and improve brain function in early studies, though more human testing is needed to ensure…
Excitatory rTMS provides small to moderate MMSE improvements in mild to moderate Alzheimer's Disease
rTMS Shows Small to Moderate Gains for Alzheimer's Patients
This meta-analysis of 143 patients with mild-to-moderate Alzheimer's Disease found that excitatory rTMS protocols resulted in small-to-moder…
A review of clinical trials suggests that repetitive transcranial magnetic stimulation may offer modest cognitive improvements for people wi…
IL-34/CSF1R signaling modulates CNS immune cell development and impacts neurodegenerative disease progression
IL-34 Signaling Pathway Shows Complex Role in Brain Disorders
This systematic review examines the role of the IL-34/CSF1R signaling axis in CNS-resident immune cells and its impact on neurological disor…
A specific signaling pathway may play a dual role in brain health, potentially protecting nerves or contributing to diseases like Alzheimer'…
eSMARTER digital platform meets non-inferiority goals for Alzheimer's genetic and biomarker result disclosure
Digital Platforms Match Clinician Support for Alzheimer's Genetic Results
This randomized non-inferiority trial of 651 adults with Alzheimer's disease found that the eSMARTER digital platform was non-inferior to cl…
A new digital platform provides a scalable way to share Alzheimer's genetic results while maintaining patient well-being and knowledge.
Organochlorine pesticide exposure is associated with a 2.19 odds ratio for Alzheimer's disease risk
Pesticide exposure linked to higher risk of Alzheimer's disease
This meta-analysis of human studies indicates a significant positive association between organochlorine pesticide (OCP) exposure and Alzheim…
New data shows a strong link between organochlorine pesticides and Alzheimer's disease, highlighting the impact of environmental toxins on b…
Impact of Domain Specific Physical Activity on Risk of All Cause Dementia
High levels of physical activity linked to lower dementia risk
A massive meta-analysis of over 4 million participants reveals that specific types of physical activity significantly influence dementia ris…
Active lifestyles, especially during leisure time, are linked to a lower risk of developing Alzheimer's and other forms of dementia.
p-tau217/Aβ42 ratio nearly doubles the diagnostic odds ratio for amyloid pathology in Alzheimer's disease
Blood Test Ratio Improves Alzheimer's Detection Accuracy
This meta-analysis of 18,073 individuals with amyloid pathology evaluated the accuracy of plasma p-tau217 and its ratio with Aβ42 across mul…
A blood test measuring two proteins may spot Alzheimer's brain changes more accurately than one protein alone, a new review finds.
Melanin-concentrating hormone serves as a key neuromodulatory network for memory and sleep in Alzheimer's disease
Brain chemical MCH may affect memory and sleep in Alzheimer's
This mini-review explores the role of melanin-concentrating hormone (MCH) in memory processing, sleep architecture, and synaptic efficacy. T…
A brain chemical called MCH may influence memory and sleep in Alzheimer's, but evidence is early and mostly from lab studies.
Exercise plus antioxidants may add neuroprotection in Alzheimer's and Parkinson's, but evidence is context-dependent
Exercise and Antioxidants May Offer Neuroprotection for Alzheimer's and Parkinson's
This narrative review examines exercise and antioxidant interventions (vitamins, selenium, zinc, flavonoids) for Alzheimer's and Parkinson's…
Combining exercise with antioxidants like vitamins and flavonoids may offer extra protection for the brain in some experimental settings.
PGE2 signaling via EP receptors drives tumor progression and context-dependent neuroinflammation in various diseases
Understanding the Role of PGE2 Signaling in Brain Health and Cancer
This systematic review examines the role of PGE2 signaling across neurological, oncological, and metabolic conditions. The findings indicate…
New research shows how different parts of a single protein pathway can either protect your brain or help tumors grow.
Ginseng components show potential neuroprotective effects in preclinical models of multiple neurodegenerative diseases
Ginsenosides Show Potential Neuroprotective Effects for Several Brain Diseases
This systematic review synthesizes evidence regarding the role of ginseng and its active components, such as ginsenosides, in models of Alzh…
Research into ginseng components suggests potential neuroprotective benefits for conditions like Alzheimer's and Parkinson's, though results…