Research across Cancer
Related studies from across the Cancer family.
Trastuzumab Deruxtecan Management of HER2 Positive Metastatic Breast Cancer with Visceral Crisis
Newer drug shows promise for advanced breast cancer and liver issues
A case report highlights the efficacy of trastuzumab deruxtecan in managing visceral crisis in HER2-positive metastatic breast cancer.
A new treatment approach may help patients with advanced breast cancer who are facing a sudden, serious crisis in their liver function.
Evaluating AI and Manual Stromal Immune Cell Quantification in HER2 Positive Breast Cancer
AI tools help predict outcomes for HER2-positive breast cancer
This Phase 3 analysis evaluates how manual, digital, and AI-based sTIL quantification impact prognostic and predictive outcomes in HER2+ bre…
New analysis shows that AI and manual counts of immune cells can help predict how well patients with HER2-positive breast cancer respond to …
Datopotamab deruxtecan showed no overall survival benefit versus investigator's choice chemotherapy in metastatic HR-positive breast cancer.
Datopotamab deruxtecan extends life for advanced breast cancer patients
This Phase III randomized controlled trial evaluated datopotamab deruxtecan versus investigator's choice chemotherapy in patients with inope…
New drug datopotamab deruxtecan helps advanced breast cancer patients live longer and stay disease-free
Statins reduce recurrence risk 23% and mortality in 267,913 HR+ breast cancer patients with HR 0.77
Statins lower recurrence and death risk in hormone receptor-positive breast cancer
This systematic review and meta-analysis evaluated statin use versus non-use in 267,913 patients with hormone receptor-positive breast cance…
A massive analysis of over 267,000 patients shows statins reduce recurrence and death risk in hormone receptor-positive breast cancer.
Immunotherapy improves complete response but lacks overall response benefit in HR+ breast cancer
Immunotherapy shows mixed results for hormone-positive breast cancer patients
This systematic review and meta-analysis evaluated immunotherapy in patients with hormone receptor-positive and human epidermal growth facto…
A large analysis found immunotherapy did not improve overall survival but did increase side effects for hormone-positive breast cancer patie…
Trastuzumab deruxtecan improves PFS vs chemotherapy in HR-positive, HER2-low breast cancer
Trial shows T-DXd beats chemo for breast cancer
In a phase 3 RCT of 866 patients with HR-positive, HER2-low/-ultralow metastatic breast cancer after endocrine therapy, trastuzumab deruxtec…
A new drug, T-DXd, helps people with a common type of advanced breast cancer live longer without their disease getting worse.
Review covers capecitabine and trastuzumab emtansine for triple-negative and HER2-positive breast cancer
Breast Cancer Chemo Is Getting Smarter and More Effective
This narrative review examines emerging therapies for women with breast cancer, including triple-negative and HER2-positive disease. The aut…
New blood tests and tumor markers are helping doctors choose the right chemo for breast cancer, reducing resistance and improving survival.
FDA Approves Enhertu (fam-trastuzumab deruxtecan-nxki) for Multiple HER2-Positive and HER2-Low Cancers
FDA approves Enhertu for several types of HER2 positive cancers.
FDA approved Enhertu for several indications including HER2-positive metastatic breast cancer, HER2-low and HER2-ultralow breast cancer, HER…
The FDA has approved Enhertu for multiple cancers, including breast, lung, stomach, and other solid tumors that have a specific protein call…
CDK4/6i plus AI or fulvestrant shows similar clinical benefit in HR+ HER2- MBC
Two drugs linked to longer survival than palbociclib in breast cancer
This retrospective single-center analysis of 341 patients with HR+/HER2− MBC found that palbociclib, abemaciclib, and dalpiciclib combined w…
In a real-world analysis, two CDK4/6 inhibitors showed longer survival times than palbociclib for metastatic breast cancer patients.
Review of 35 cases highlights diagnostic challenges in gastric metastasis from invasive lobular breast cancer
Breast Cancer Spreads to Stomach: Why Testing Must Change
This case report and literature review synthesizes data from 35 recent cases (2019–2024) of gastric metastasis from breast cancer.
Doctors must re-test stomach issues in breast cancer patients because the cells often change their identity.
Retrospective analysis identifies risk factors for trastuzumab-induced cardiotoxicity in HER2-positive breast cancer patients
Many Breast Cancer Patients Can Avoid Heart Damage — If Doctors Know the Warning Signs
This retrospective analysis of 298 HER2-positive breast cancer patients assessed trastuzumab-induced cardiotoxicity.
This could help doctors protect patients’ hearts before cancer therapy even begins.
Review of survey data highlights high rates of misdiagnosis and delayed diagnosis in metastatic invasive lobular breast cancer
One in Four Metastatic Breast Cancer Patients Misdiagnosed at First Visit
This cross-sectional survey review analyzed patient-reported data from 525 individuals with invasive lobular breast cancer (ILC).
One in four metastatic breast cancer patients were misdiagnosed at their first doctor visit, delaying care for a stealthy cancer that spread…
Questions about Breast Cancer-Related Lymphedema
Does axillary reverse mapping lower the chance of developing breast cancer-related lymphedema?
Axillary reverse mapping significantly lowers the risk of developing breast cancer-related lymphedema compared to standard surgery, with studies showing a much lower chance of the condition occurring.
Full answer →Which surgical technique reduces the risk of breast cancer-related lymphedema best?
Axillary reverse mapping and lymphovascular anastomoses are the two surgical techniques with the strongest evidence for reducing the risk of breast cancer-related lymphedema.
Full answer →Will transcutaneous electrical acupoint stimulation pretreatment help prevent breast cancer-related lymphedema?
Current high-quality evidence does not yet confirm if transcutaneous electrical acupoint stimulation (TEAS) prevents breast cancer-related lymphedema, as a major trial is currently underway to test this specific question.
Full answer →