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Home › Conditions › Breast Reconstruction

Breast Reconstruction

2 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Breast Reconstruction

18 trials tracked for Breast Reconstruction: 6 in phase 3 or 4 and 4 with published results. The most-cited published study has 74 citations.

18Trials tracked
6Phase 3 & 4
0Recruiting
4With published results
Phase distribution
Phase 4 3 Phase 3 3 Phase 2 1 Other / NA 11
  1. Phase 3 Mentor Siltex® Contour Profile Gel Mammary Prosthesis Clinical Trial Completed · 74 cited
  2. Phase 4 Impact of the Serratus Plane Block in Pain and the Use of Opioids in Breast Surgery Completed · 44 cited
  3. Phase 4 Effectiveness of Exparel TAP Block in Breast Free Flap Reconstruction Completed · 22 cited
  4. Phase 4 Comparing Local Anesthetics for TAP Block During Abdominally-based Free Flap for Breast Reconstruction Completed · 17 cited
  5. Phase 3 CPG Styles Study: A Study of the Safety of the Contour Profile Gel Breast Implants (CPG Styles Study) Completed
  6. Phase 3 Core Gel Study of the Safety and Effectiveness of Mentor Round Low Bleed Silicone Gel-filled Mammary Prostheses Completed
Show 12 more trials
  1. Phase 2 Immunophenotyping of Fresh Stromal Vascular Fraction From Adipose Derived Stem Cells (ADSC) Enriched Fat Grafts Completed
  2. N/A Safety and Effectiveness of Style 410 Silicone-Filled Breast Implant Study Completed
  3. N/A Evaluation of the Cook Biodesign® Nipple Reconstruction Cylinder (NRC) Completed
  4. N/A The SERI® Surgical Scaffold Use in Reconstruction Post Market Study for Tissue Support and Repair in Breast Reconstruction Surgery Completed
  5. N/A Safety and Effectiveness of Natrelle(TM) Cohesive Round Silicone-Filled Breast Implants Completed
  6. N/A Randomized Controlled Trial of Subcuticular Skin Closure Versus Steri-strip S Closure Completed
  7. N/A The Use of Alloderm Versus Dermacell in Immediate Implant Based Breast Reconstruction Completed
  8. N/A Implementing BREASTChoice Into Practice Completed
  9. N/A Mentor MemoryGel Post-Approval Study Completed
  10. N/A Sientra Sponsored Silimed Gel-Filled Breast Implant Core Clinical Study Completed
  11. N/A A Pilot Study to Evaluate the BodyLogic TM System (Mentor) in Augmentation Mammaplasty Completed
  12. N/A Adjunct Study of Natrelle(TM) Cohesive Round Silicone-Filled Breast Implants Completed

Showing the 18 most-cited and recently-updated of 18 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

What the trials found Updated — new results For clinicians

Breast Reconstruction: what the trials found

Established evidence includes the use of Serrato, which significantly reduced total opioid usage (p < 0.05) 2. Liposomal bupivacaine was shown to result in post-op pain scores of 4.3 and 3.3 3, while its use alone was noted as an established intervention 4. Several types of silicone-filled breast implants, including Natrelle(TM) [15, 18] and Mentor Round Low Bleed Gel-filled Mammary Protheses (Siltex and Smooth Surface) 7, are established. Additionally, the Mentor Siltex® Contour Profile Gel Mammary Prosthesis 5 and The Contour Profile Gel (CPG) breast implants 6 are established.

N/A

Recent results — preliminary, needs further review

  • Alloderm was evaluated for postoperative duration of drain placements, but results were not statistically significant (p=0.15) 1.

For the clinician treating this condition

  • Serrato is associated with a statistically significant reduction in total opioid usage 2.
  • Liposomal bupivacaine is an established intervention for pain management [3, 4].
  • Multiple silicone-filled and contour profile gel implants are established options for breast reconstruction [5, 6, 7, 15, 18].

AI synthesis of 7 cited trials, updated Jul 8, 2026. Informational only — not medical advice; trial data sourced from ClinicalTrials.gov. How we use AI.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Combining CTA and US reduces complication rates in DIEP flap reconstruction compared to US alone
Radiology & Imaging Meta-analysis
Combining CTA and US reduces complication rates in DIEP flap reconstruction compared to US alone Combining imaging tests may lower complications in breast reconstruction
This meta-analysis of 3238 patients evaluates preoperative imaging modalities for DIEP flap reconstruction. The analysis indicates that comb…
Using both CT scans and ultrasounds together during surgery can reduce complication rates for patients undergoing DIEP flap reconstruction.
Jul 27, 2026
Online patient education materials for breast reconstruction show low usability and high reading levels
Primary Care & Family Medicine Meta-analysis
Online patient education materials for breast reconstruction show low usability and high reading levels Online Breast Reconstruction Resources Often Hard for Patients to Read
This systematic review and meta-analysis of 1634 online patient education materials (OPEMs) found that content is often difficult to read an…
Most online materials about breast reconstruction are written at a college level, making it difficult for many patients to find clear inform…
Jul 27, 2026