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Home › Conditions › Complicated Appendicitis

Complicated Appendicitis

3 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Complicated Appendicitis

3 trials tracked for Complicated Appendicitis: 2 in phase 3 or 4 and 1 with published results. The most-cited published study has 205 citations.

3Trials tracked
2Phase 3 & 4
0Recruiting
1With published results
Phase distribution
Phase 4 1 Phase 3 1 Phase 2 1
  1. Phase 3 Efficacy and Safety Study of Eravacycline Compared With Meropenem in Complicated Intra-abdominal Infections Completed · 205 cited
  2. Phase 4 Optimal Care of Complicated Appendicitis Completed
  3. Phase 2 Antibiotic Instillation in Appendicitis Completed

Showing the 3 most-cited and recently-updated of 3 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Peripheral blood inflammatory markers associated with complicated acute appendicitis in retrospective cohort study
Orthopedics & Sports Medicine Cohort
Peripheral blood inflammatory markers associated with complicated acute appendicitis in retrospective cohort study Blood marker helps predict complicated appendicitis severity
This retrospective study of 533 patients evaluated the diagnostic value of peripheral blood composite inflammatory markers for identifying c…
Doctors may soon use a specific blood marker to tell if your appendicitis is simple or turning into a much more serious complication.
Frontiers Apr 30, 2026
NLR, SII, and appendiceal diameter combination shows diagnostic accuracy for complicated appendicitis
Orthopedics & Sports Medicine Cohort
NLR, SII, and appendiceal diameter combination shows diagnostic accuracy for complicated appendicitis Can simple blood tests and a scan help doctors spot a more serious appendicitis?
A retrospective single-center diagnostic cohort study of 207 patients with pathologically confirmed appendicitis found that combining…
Combining two simple blood markers with a scan width helps doctors spot serious appendicitis about 87% of the time before surgery.
Frontiers Apr 3, 2026
Short-course antibiotics after appendectomy for complicated appendicitis show similar infection risk to long-course therapy
Infectious Disease Meta-analysis
Short-course antibiotics after appendectomy for complicated appendicitis show similar infection risk to long-course therapy Short-course antibiotics after complicated appendectomy show similar infection risk to longer courses
A meta-analysis of 3251 patients from 4 RCTs and 9 observational studies found short-course antibiotic therapy (<3 days) after appendectomy …
Shorter antibiotics after complicated appendectomy carry similar infection risks to longer courses while often shortening hospital stays.
Apr 2, 2026

Questions about Complicated Appendicitis

What appendiceal diameter helps diagnose complicated appendicitis in patients?

A maximum appendiceal diameter of 10.5 mm or greater helps diagnose complicated appendicitis, though a larger cutoff of 14.5 mm is also noted in other research.

Full answer →