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COVID-19 pneumonia

Part of Pneumonia

1 published article · Updated continuously

Clinical Trial Landscape

Clinical Trials for COVID-19 pneumonia

11 trials tracked for COVID-19 pneumonia: 3 in phase 3 or 4 and 2 with published results. The most-cited published study has 1329 citations.

11Trials tracked
3Phase 3 & 4
0Recruiting
2With published results
Phase distribution
Phase 3 3 Phase 2 5 Other / NA 3
  1. Phase 3 A Study to Evaluate the Efficacy and Safety of Tocilizumab in Hospitalized Participants With COVID-19 Pneumonia Completed · 1,329 cited
  2. Phase 3 A Study to Evaluate the Safety and Efficacy of Tocilizumab in Patients With Severe COVID-19 Pneumonia Completed · 1,096 cited
  3. Phase 3 A Study to Evaluate the Efficacy and Safety of Remdesivir Plus Tocilizumab Compared With Remdesivir Plus Placebo in Hospitalized Participants With Severe COVID-19 Pneumonia Completed
  4. Phase 2 Clinical Trial to Evaluate CERC-002 in Adults With COVID-19 Pneumonia and Acute Lung Injury Completed
  5. Phase 2 Multiple Dosing of Mesenchymal Stromal Cells in Patients With ARDS (COVID-19) Completed
  6. Phase 2 Double-blind, Randomized, Controlled Clinical Trial to Assess Efficacy of MSC in Patients With COVID-19 ARDS Completed
Show 5 more trials
  1. Phase 2 A Study to Investigate Intravenous Tocilizumab in Participants With Moderate to Severe COVID-19 Pneumonia Completed
  2. Phase 2 A Study to Evaluate the Safety and Efficacy of MSTT1041A (Astegolimab) or UTTR1147A in Patients With Severe COVID-19 Pneumonia Completed
  3. N/A The Development of a COVID19 Oral Vaccine Consisting of Bacillus Subtilis Spores Completed
  4. N/A Association of Androgenetic Alopecia and Severity of Coronavirus Disease 2019 (COVID-19). Completed
  5. N/A Therapeutic Plasma Exchange Followed by Convalescent Plasma Transfusion in Severe and Critically Ill COVID-19 Patients Completed

Showing the 11 most-cited and recently-updated of 11 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.

Research across Pneumonia

Related studies from across the Pneumonia family.

Antibiotic exposure disrupts gut microbiota in 58% to 94% of critically ill children
Infectious Disease Sys. Review
Antibiotic exposure disrupts gut microbiota in 58% to 94% of critically ill children Antibiotics and gut health in critically ill children
This narrative review examines antibiotic exposure in critically ill children in the PICU, reporting that 58% to 94% receive antibiotics, wh…
Common antibiotics used in intensive care can disrupt a child's gut health, increasing the risk of serious infections like pneumonia.
iNKT cell activators show promise in preclinical models for stroke-associated pneumonia immunomodulation
Pulmonology & Critical Care Meta-analysis
iNKT cell activators show promise in preclinical models for stroke-associated pneumonia immunomodulation New immune treatments show promise for stroke and pneumonia
This systematic review of 38 preclinical studies examines the immunopathology of stroke-associated pneumonia (SAP) and the role of immunomod…
Researchers identify how stroke triggers immune failure and find a promising new way to protect the lungs from pneumonia infections.
IL-6 overexpression linked to alveolar damage in severe pneumonia on ventilation
Primary Care & Family Medicine Sys. Review
IL-6 overexpression linked to alveolar damage in severe pneumonia on ventilation IL-6 Levels Linked to Lung Damage in Severe Pneumonia
This narrative review synthesizes basic and clinical evidence on IL-6 in mechanically ventilated patients with severe pneumonia. It finds th…
High levels of a protein called IL-6 may be linked to increased lung damage and inflammation in patients with severe pneumonia.
Low-dose corticosteroids reduce 90-day mortality in adults with severe community-acquired pneumonia
Pulmonology & Critical Care Meta-analysis
Low-dose corticosteroids reduce 90-day mortality in adults with severe community-acquired pneumonia Low dose steroids may lower death rates in severe lung infections
This meta-analysis of 4,622 patients found that low-dose corticosteroids (≤400 mg hydrocortisone-equivalent daily) significantly reduced sho…
A review of clinical trials suggests that low-dose corticosteroids can reduce 90-day mortality for adults with severe lung infections like p…
Oral amoxicillin or amoxicillin-clavulanate is non-inferior to intravenous treatment for severe CAP in children
Pediatrics RCT
Oral amoxicillin or amoxicillin-clavulanate is non-inferior to intravenous treatment for severe CAP in children Trial shows oral antibiotics work for children with severe pneumonia
This randomized controlled trial of 1,101 children with severe community-acquired pneumonia in sub-Saharan Africa found that step-down oral …
A large trial in Africa found that switching children from IV to oral antibiotics for pneumonia is as safe and effective as staying on IV tr…
Impact of Systemic Prophylactic Antibacterials on Ventilator Associated Pneumonia in ICU Patients
Infectious Disease Meta-analysis
Impact of Systemic Prophylactic Antibacterials on Ventilator Associated Pneumonia in ICU Patients Antibacterials may lower pneumonia rates in patients on ventilators
Meta-analysis data suggests systemic prophylactic antibacterials significantly reduce the incidence of ventilator-associated pneumonia in IC…
A large review suggests that using certain medications can help prevent lung infections in patients requiring breathing machines in the ICU.
Nursing Care Improves Pediatric Pneumonia Outcomes
Pediatrics Meta-analysis
Nursing Care Improves Pediatric Pneumonia Outcomes Nursing care boosts satisfaction, cuts pneumonia complications in kids
Meta-analysis of 166,859 pediatric pneumonia cases shows nursing interventions boost satisfaction and cut complications.
Structured nursing care for children with pneumonia improves satisfaction and reduces complications, a large meta-analysis finds.
Precision synbiotic reduces URTI incidence from 85.4% to 55.4% in toddlers
Nutrition & Obesity Medicine RCT
Precision synbiotic reduces URTI incidence from 85.4% to 55.4% in toddlers New synbiotic formula may cut common toddler infections and eczema
This multicenter randomized controlled trial of 390 healthy toddlers aged 1-3 years found that a precision synbiotic significantly reduced u…
A new combination of a specific sugar and healthy bacteria could significantly reduce respiratory infections, diarrhea, and skin issues in t…
Protocol for comparing azithromycin and doxycycline with beta-lactams in community-acquired pneumonia
Infectious Disease RCT
Protocol for comparing azithromycin and doxycycline with beta-lactams in community-acquired pneumonia New trial to test azithromycin vs doxycycline for pneumonia
This is a protocol for a planned randomized clinical trial involving 1120 adult patients hospitalized with community-acquired pneumonia. No …
A large trial will compare two antibiotic combos for hospitalized pneumonia patients. Which works better?
AI models provide high accuracy for pulmonary inflammation and COVID-19 detection in diverse populations
Rheumatology Sys. Review
AI models provide high accuracy for pulmonary inflammation and COVID-19 detection in diverse populations Artificial Intelligence Shows Promise for Detecting Lung Inflammation
This mini-review synthesizes evidence on artificial intelligence applications for detecting pulmonary inflammation and managing perioperativ…
New research shows that artificial intelligence tools can accurately identify lung conditions like pneumonia and COVID-19 from medical imagi…
Airway clearance techniques triple odds of treatment success in Chinese pneumonia patients
Rheumatology Meta-analysis
Airway clearance techniques triple odds of treatment success in Chinese pneumonia patients Airway clearance techniques may improve treatment for pneumonia patients
This meta-analysis of RCTs in Chinese adults with pneumonia found that adding airway clearance techniques to conventional treatment signific…
Adding airway clearance to standard care may help Chinese adults with pneumonia breathe better and face fewer complications.
Short-course antibiotic therapy yields comparable clinical and bacteriological success for adults with community-acquired pneumonia
Rheumatology Meta-analysis
Short-course antibiotic therapy yields comparable clinical and bacteriological success for adults with community-acquired pneumonia Shorter antibiotics work just as well for pneumonia
This meta-analysis of 21 RCTs found that short-course antibiotic therapy (≤5 days) provides comparable clinical, bacteriological, and radiol…
For adults with pneumonia, 5 days or less of antibiotics works as well as longer courses, with fewer severe side effects.