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COVID-19 pneumonia

Part of Pneumonia

1 published article · Updated continuously

Clinical Trial Landscape

Clinical Trials for COVID-19 pneumonia

11 trials tracked for COVID-19 pneumonia: 3 in phase 3 or 4 and 2 with published results. The most-cited published study has 1327 citations.

11Trials tracked
3Phase 3 & 4
0Recruiting
2With published results
Phase distribution
Phase 3 3 Phase 2 5 Other / NA 3
  1. Phase 3 A Study to Evaluate the Efficacy and Safety of Tocilizumab in Hospitalized Participants With COVID-19 Pneumonia Completed · 1,327 cited
  2. Phase 3 A Study to Evaluate the Safety and Efficacy of Tocilizumab in Patients With Severe COVID-19 Pneumonia Completed · 1,091 cited
  3. Phase 3 A Study to Evaluate the Efficacy and Safety of Remdesivir Plus Tocilizumab Compared With Remdesivir Plus Placebo in Hospitalized Participants With Severe COVID-19 Pneumonia Completed
  4. Phase 2 Clinical Trial to Evaluate CERC-002 in Adults With COVID-19 Pneumonia and Acute Lung Injury Completed
  5. Phase 2 Multiple Dosing of Mesenchymal Stromal Cells in Patients With ARDS (COVID-19) Completed
  6. Phase 2 Double-blind, Randomized, Controlled Clinical Trial to Assess Efficacy of MSC in Patients With COVID-19 ARDS Completed
Show 5 more trials
  1. Phase 2 A Study to Investigate Intravenous Tocilizumab in Participants With Moderate to Severe COVID-19 Pneumonia Completed
  2. Phase 2 A Study to Evaluate the Safety and Efficacy of MSTT1041A (Astegolimab) or UTTR1147A in Patients With Severe COVID-19 Pneumonia Completed
  3. N/A The Development of a COVID19 Oral Vaccine Consisting of Bacillus Subtilis Spores Completed
  4. N/A Association of Androgenetic Alopecia and Severity of Coronavirus Disease 2019 (COVID-19). Completed
  5. N/A Therapeutic Plasma Exchange Followed by Convalescent Plasma Transfusion in Severe and Critically Ill COVID-19 Patients Completed

Showing the 11 most-cited and recently-updated of 11 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.

Research across Pneumonia

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AI diagnostic tools show high accuracy but limited real-world validation in systematic review
Oncology Meta-analysis
AI diagnostic tools show high accuracy but limited real-world validation in systematic review Artificial intelligence shows high accuracy in detecting various medical conditions
This systematic review of 24 studies synthesizes evidence on AI and deep learning for disease detection across multiple imaging modalities. …
New analysis of 24 studies shows AI tools can reach over 90% accuracy in spotting everything from lung cancer to skin disorders.
CD4+ T cells and Tim-3 regulate immune responses and cytokine-mediated injury in severe pediatric pneumonia
Gastroenterology Sys. Review
CD4+ T cells and Tim-3 regulate immune responses and cytokine-mediated injury in severe pediatric pneumonia Immune system hurdles shape severity of severe childhood pneumonia
This narrative review examines how CD4+ T cells, Tim-3 (HAVCR2), and cytokines influence the host immune response in severe pneumonia. The a…
New research explores how specific immune cells and proteins may drive the intense inflammation seen in children with severe pneumonia.
Brain-Lung-Immune-Microbiome Axis replaces biomechanical models in understanding ventilator-associated pneumonia after traumatic brain injury
Infectious Disease Sys. Review
Brain-Lung-Immune-Microbiome Axis replaces biomechanical models in understanding ventilator-associated pneumonia after traumatic brain injury New Framework Explains Lung Infections After Brain Injuries
This narrative review explores the transition from a traditional biomechanical model of ventilator-associated pneumonia to a multidimensiona…
A new model suggests that brain injuries create a complex immune and microbiome response that leads to lung infections in intensive care pat…
Adrenergic receptor signaling modulates pulmonary innate immunity and barrier integrity in acute lung injury
Diabetes & Endocrinology Sys. Review
Adrenergic receptor signaling modulates pulmonary innate immunity and barrier integrity in acute lung injury Understanding How Nerve Signals Influence Lung Health During Severe Respiratory Infections
This systematic review synthesizes the role of adrenergic receptors (ARs) as a molecular interface between the sympathetic nervous system an…
New research explores how specific nerve signals help control inflammation and protect the lungs during severe lung infections.
Colistin-based inhalation regimens rank highest for clinical response in multidrug-resistant Acinetobacter baumannii pneumonia
Infectious Disease Sys. Review
Colistin-based inhalation regimens rank highest for clinical response in multidrug-resistant Acinetobacter baumannii pneumonia Colistin Inhalation Tops for Drug-Resistant Pneumonia
This network meta-analysis of 1420 patients with multidrug-resistant Acinetobacter baumannii (MDRAB) pneumonia compared colistin, tigecyclin…
For tough pneumonia, inhaled colistin works best, but sulbactam is a good alternative without the toxicity.
Nebulised Chinese herbal medicine as adjunctive therapy improves clinical effective rate in pediatric pneumonia
Pediatrics Meta-analysis
Nebulised Chinese herbal medicine as adjunctive therapy improves clinical effective rate in pediatric pneumonia Chinese Herbal Medicine Boosts Pneumonia Treatment in Children
This meta-analysis of randomized controlled trials evaluated nebulised Chinese herbal medicine as an adjunctive therapy for pediatric pneumo…
Adding nebulised Chinese herbal medicine to standard care improved pneumonia recovery in children, a meta-analysis of 1,764 patients found.
No risk score outperformed WHO IMCI criteria for predicting pediatric pneumonia mortality
Infectious Disease RCT
No risk score outperformed WHO IMCI criteria for predicting pediatric pneumonia mortality Risk Scores Do Not Outperform Standard Care for Pneumonia
This secondary analysis of a randomized controlled trial evaluated five risk scores in 1010 children with pneumonia across five African coun…
New analysis shows standard clinical tools are just as effective as complex risk scores for predicting pneumonia outcomes in children.
Evaluating the Impact of Rapid Diagnostic Panels on Pediatric Pneumonia Management
Pediatrics RCT
Evaluating the Impact of Rapid Diagnostic Panels on Pediatric Pneumonia Management New Testing Panel May Help Target Antibiotics for Child Pneumonia
A randomized trial explores how rapid diagnostic panels influence antibiotic adjustments and de-escalation for children with pneumonia.
A new testing panel may help doctors more accurately target antibiotics and reduce unnecessary medications for children with pneumonia.
Inhaled antibiotics improve clinical cure and reduce mortality in ventilator-associated pneumonia
Infectious Disease Meta-analysis
Inhaled antibiotics improve clinical cure and reduce mortality in ventilator-associated pneumonia Inhaled antibiotics help cure pneumonia and lower death risk in ICU patients
This systematic review and meta-analysis of adjunctive inhaled antibiotics for ventilator-associated pneumonia found significantly improved …
Adding inhaled antibiotics to standard care improved cure rates and reduced death in patients with ventilator-associated pneumonia.
Newer antibiotics reduce nephrotoxicity and improve eradication of carbapenem-resistant gram-negative bacilli versus generic antibiotics in HABP/VABP
Infectious Disease Meta-analysis
Newer antibiotics reduce nephrotoxicity and improve eradication of carbapenem-resistant gram-negative bacilli versus generic antibiotics in HABP/VABP Newer antibiotics no better at preventing pneumonia deaths
This systematic review and meta-analysis evaluated newer antibiotics versus generic antibiotics for hospital-acquired and ventilator-associa…
Newer antibiotics for hospital-acquired pneumonia don't lower death risk more than older generics, but they do spare kidneys.
Systemic corticosteroid therapy significantly decreased length of hospital stay and fever duration in children with community-acquired pneumonia
Infectious Disease Meta-analysis
Systemic corticosteroid therapy significantly decreased length of hospital stay and fever duration in children with community-acquired pneumonia Shorter hospital stays and fever for kids with pneumonia using steroids
This systematic review and meta-analysis evaluated systemic corticosteroid therapy versus controls in children with community-acquired pneum…
A large review found that adding steroids to standard antibiotics helped children with pneumonia leave the hospital faster and get over thei…
High mortality rates observed in community-acquired pneumonia patients within intensive care units across low- and middle-income regions
Emergency Medicine Meta-analysis
High mortality rates observed in community-acquired pneumonia patients within intensive care units across low- and middle-income regions Community-acquired pneumonia kills one in three ICU patients in low- and middle-income countries
A systematic review and meta-analysis of 48,707 patients reveals stark mortality risks for community-acquired pneumonia in resource-limited …
A massive review shows that one in three patients with pneumonia admitted to ICUs in low- and middle-income countries dies within a month.