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COVID-19 pneumonia

Part of Pneumonia

1 published article · Updated continuously

Clinical Trial Landscape

Clinical Trials for COVID-19 pneumonia

11 trials tracked for COVID-19 pneumonia: 3 in phase 3 or 4 and 2 with published results. The most-cited published study has 1336 citations.

11Trials tracked
3Phase 3 & 4
0Recruiting
2With published results
Phase distribution
Phase 3 3 Phase 2 5 Other / NA 3
  1. Phase 3 A Study to Evaluate the Efficacy and Safety of Tocilizumab in Hospitalized Participants With COVID-19 Pneumonia Completed · 1,336 cited
  2. Phase 3 A Study to Evaluate the Safety and Efficacy of Tocilizumab in Patients With Severe COVID-19 Pneumonia Completed · 1,101 cited
  3. Phase 3 A Study to Evaluate the Efficacy and Safety of Remdesivir Plus Tocilizumab Compared With Remdesivir Plus Placebo in Hospitalized Participants With Severe COVID-19 Pneumonia Completed
  4. Phase 2 Clinical Trial to Evaluate CERC-002 in Adults With COVID-19 Pneumonia and Acute Lung Injury Completed
  5. Phase 2 Multiple Dosing of Mesenchymal Stromal Cells in Patients With ARDS (COVID-19) Completed
  6. Phase 2 Double-blind, Randomized, Controlled Clinical Trial to Assess Efficacy of MSC in Patients With COVID-19 ARDS Completed
Show 5 more trials
  1. Phase 2 A Study to Investigate Intravenous Tocilizumab in Participants With Moderate to Severe COVID-19 Pneumonia Completed
  2. Phase 2 A Study to Evaluate the Safety and Efficacy of MSTT1041A (Astegolimab) or UTTR1147A in Patients With Severe COVID-19 Pneumonia Completed
  3. N/A The Development of a COVID19 Oral Vaccine Consisting of Bacillus Subtilis Spores Completed
  4. N/A Association of Androgenetic Alopecia and Severity of Coronavirus Disease 2019 (COVID-19). Completed
  5. N/A Therapeutic Plasma Exchange Followed by Convalescent Plasma Transfusion in Severe and Critically Ill COVID-19 Patients Completed

Showing the 11 most-cited and recently-updated of 11 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.

Research across Pneumonia

Related studies from across the Pneumonia family.

EV-D68 infection may cause plastic bronchitis and severe pneumonia in pediatric patients
Cardiology Sys. Review
EV-D68 infection may cause plastic bronchitis and severe pneumonia in pediatric patients EV-D68 Infection Linked to Severe Lung Issues in Children
This case report and literature review describes a single 11-year-old girl with Enterovirus D68 infection leading to plastic bronchitis and …
A new case report identifies Enterovirus D68 as a potential cause of severe pneumonia and plastic bronchitis in children.
Short-course antibiotic therapy reduces medication non-adherence in children with non-severe community-acquired pneumonia
Pediatrics Meta-analysis
Short-course antibiotic therapy reduces medication non-adherence in children with non-severe community-acquired pneumonia Short antibiotic courses may help children finish their full prescriptions
This meta-analysis of 10 trials (n = 8970) found that short-course antibiotic therapy (≤ 5 days) for non-severe pediatric community-acquired…
Shorter antibiotic courses for mild pneumonia in children may help them stay on track with their medication without reducing treatment succe…
Higher baseline Prognostic Nutritional Index reduces mortality risk in sepsis and pneumonia patients
Rheumatology Meta-analysis
Higher baseline Prognostic Nutritional Index reduces mortality risk in sepsis and pneumonia patients Nutritional status helps predict survival in patients with severe infections
This meta-analysis of 28,757 patients with infectious diseases found that higher baseline Prognostic Nutritional Index (PNI) is associated w…
A high nutritional score at the start of treatment can help doctors identify which patients with sepsis or pneumonia are at the highest risk…
Omadacycline and baloxavir marboxil used in an 89-year-old with influenza A, psittacosis, and Klebsiella pneumonia
Rheumatology Sys. Review
Omadacycline and baloxavir marboxil used in an 89-year-old with influenza A, psittacosis, and Klebsiella pneumonia New drug combination helps elderly man with severe lung infections
This case report describes an 89-year-old man with influenza A, Chlamydia psittaci pneumonia, and Klebsiella pneumoniae who improved and was…
A combination of omadacycline and baloxavir marboxil helped an 89-year-old man recover from a complex, multi-organ infection in the ICU.
Autoantibody positivity and false-negative cytology can mask invasive mucinous adenocarcinoma in patients with IPAF
Allergy & Immunology Sys. Review
Autoantibody positivity and false-negative cytology can mask invasive mucinous adenocarcinoma in patients with IPAF Lung cancer can mimic autoimmune lung disease in some patients
This case report describes a 78-year-old female with invasive mucinous adenocarcinoma and interstitial pneumonia with autoimmune features. T…
A new case shows how a rare lung cancer can look like an autoimmune disease, making it hard for doctors to tell them apart.
MRSA nares PCR does not cut vancomycin duration in ICU CAP
Infectious Disease RCT
MRSA nares PCR does not cut vancomycin duration in ICU CAP MRSA Testing Does Not Reduce Vancomycin Use in Pneumonia Patients
In a single-center randomized trial of 277 adult ICU patients with suspected community-acquired pneumonia, MRSA nares PCR testing did not si…
A trial of 277 ICU patients found that MRSA nasal swab testing did not reduce the amount of vancomycin used for pneumonia.
Physical frailty tops risk factors for pneumonia after esophagectomy, meta-analysis finds
Geriatrics & Aging Meta-analysis
Physical frailty tops risk factors for pneumonia after esophagectomy, meta-analysis finds Physical frailty and muscle loss increase pneumonia risk after surgery
This meta-analysis of 60 cohort studies in esophageal cancer patients undergoing esophagectomy identified physical frailty as the highest-ra…
Patients with esophageal cancer face a higher risk of pneumonia after surgery if they show signs of physical frailty or muscle loss.
Short-course ceftriaxone reduces hospital stay and adverse events in children with pneumonia
Infectious Disease RCT
Short-course ceftriaxone reduces hospital stay and adverse events in children with pneumonia Shorter antibiotic courses may help children with pneumonia stay home
This randomized controlled trial of 200 children aged 1 to 14 years found that short-course ceftriaxone (5 to 7 days) resulted in shorter ho…
A new trial shows that a shorter course of ceftriaxone can reduce hospital stays and side effects for children with pneumonia.
Aerosolized liposomal amphotericin B provides strongest evidence for invasive pulmonary aspergillosis prophylaxis in high-risk patients
Gastroenterology Sys. Review
Aerosolized liposomal amphotericin B provides strongest evidence for invasive pulmonary aspergillosis prophylaxis in high-risk patients Aerosolized Amphotericin B Shows Promise for Lung Fungal Infections
This mini review synthesizes clinical experience regarding aerosolized antifungal therapies for various pulmonary fungal infections. It conc…
Aerosolized liposomal amphotericin B shows promise for preventing specific lung fungal infections in high-risk and immunocompromised patient…
mNGS achieves 85.83% pathogen detection rate in children with severe pneumonia compared to 49.97% for conventional methods
Pediatrics Sys. Review
mNGS achieves 85.83% pathogen detection rate in children with severe pneumonia compared to 49.97% for conventional methods New Genetic Test Finds More Pneumonia Germs in Kids
This systematic review evaluates metagenomic next-generation sequencing (mNGS) for identifying pathogens in children with severe pneumonia. …
A new genetic test detects pneumonia-causing germs in kids more often than standard methods, which could lead to better treatment.
Inhaled antibiotics may improve lung function and microbiological eradication in cystic fibrosis and bronchiectasis
Infectious Disease Meta-analysis
Inhaled antibiotics may improve lung function and microbiological eradication in cystic fibrosis and bronchiectasis Inhaled Antibiotics May Improve Lung Health in Chronic Lung Conditions
This meta-analysis evaluated the efficacy of inhaled antibiotics for patients with cystic fibrosis, non-cystic fibrosis bronchiectasis, and …
Inhaled antibiotics may improve lung function and clear infections for people with cystic fibrosis and other chronic lung conditions.
Antibiotic exposure disrupts gut microbiota in 58% to 94% of critically ill children
Infectious Disease Sys. Review
Antibiotic exposure disrupts gut microbiota in 58% to 94% of critically ill children Antibiotics and gut health in critically ill children
This narrative review examines antibiotic exposure in critically ill children in the PICU, reporting that 58% to 94% receive antibiotics, wh…
Common antibiotics used in intensive care can disrupt a child's gut health, increasing the risk of serious infections like pneumonia.