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Home › Conditions › Dehydration

Dehydration

Part of Water-Electrolyte Imbalance

0 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Dehydration

12 trials tracked for Dehydration: 4 in phase 3 or 4 and 1 with published results. The most-cited published study has 35 citations.

12Trials tracked
4Phase 3 & 4
0Recruiting
1With published results
Phase distribution
Phase 4 4 Phase 2 1 Phase 1 1 Other / NA 6
  1. Phase 4 Subcutaneous Rehydration Compared to Intravenous Rehydration Completed · 35 cited
  2. Phase 4 Descriptive Study of Cardiac Output During Rehydration With Recombinant Human Hyaluronidase in Pediatrics Completed
  3. Phase 4 Study of Techniques of Subcutaneous Administration of Fluids Enabled by Human Recombinant Hyaluronidase Completed
  4. Phase 4 Study of Subcutaneous Rehydration With Recombinant Human Hyaluronidase for Infants and Children Completed
  5. Phase 2 IV Glucose for Dehydration Treatment Completed
  6. Phase 1 EASI Access II --- Follow-up Study to the EASI Access Trial Completed
Show 6 more trials
  1. N/A Ultrasound of the Inferior Vena Cava (IVC) and Dehydration Status in Pediatric Emergency Patients Completed
  2. N/A Buoy Electrolyte Study on Hydration Status of Active Men and Women Completed
  3. N/A LifeFlow Fluid Study- Non- Critical Pediatric Patients Having a Trans Abdominal Ultrasound Completed
  4. N/A Parenteral Hydration in Advanced Cancer Patients Completed
  5. N/A Rotavirus Burden and Genotypes in a Sentinel Hospital Surveillance System in Lebanon Completed
  6. N/A Analysis of Sweat Secretion and Body Dehydration Monitoring Completed

Showing the 12 most-cited and recently-updated of 12 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

What the trials found For clinicians

Dehydration: what the trials found

Clinical evidence regarding the management of dehydration includes the use of recombinant human hyaluronidase and Hylenex [1, 2]. In studies evaluating recombinant human hyaluronidase, mean total volumes of fluid administered at single infusion sites or across all infusion sites did not show statistically significant differences between groups (p=0.5064; p=0.5035) 1.

The administration of hyaluronidase combined with rehydration fluid was associated with a post-treatment Gorelick Dehydration Score of 0.5 and -3.0 3. Additionally, the use of Hylenex-facilitated subcutaneous Lactated Ringer's infusion demonstrated consistent times for infusing 1000 mL of fluid across study groups (approximately 6.8 minutes) 4.

Recent results — preliminary, needs further review

  • Administration of 5% Dextrose in Normal Saline (D5 in NS) for acute gastroenteritis was associated with a significant increase in serum ketones (1.10 to 2.39, p=0.0003) 5.
  • Other interventions under investigation include human recombinant hyaluronidase (HRH) 6, Buoy Electrolyte 7, LifeFlow 9, and the Spectrophon dehydration body monitor 10.

For the clinician treating this condition

  • Hyaluronidase-based interventions, including Hylenex, are established in clinical literature for managing hydration status [1, 2].
  • Hylenex-facilitated subcutaneous Lactated Ringer's infusion provides a consistent timeframe for delivering 1000 mL of fluid 4.

AI synthesis of 8 cited trials, updated Jun 29, 2026. Informational only — not medical advice; trial data sourced from ClinicalTrials.gov. How we use AI.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
No published articles yet for this condition. Check back soon.