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Dental pain

1 published article · Updated continuously

Clinical Trial Landscape

Clinical Trials for Dental pain

16 trials tracked for Dental pain: 6 in phase 3 or 4 and 1 with published results. The most-cited published study has 41 citations.

16Trials tracked
6Phase 3 & 4
0Recruiting
1With published results
Phase distribution
Phase 4 2 Phase 3 4 Phase 2 8 Phase 1 1 Other / NA 1
  1. Phase 3 Maxigesic 325 Acute Dental Pain Study Completed · 41 cited
  2. Phase 4 Buffered Local Anesthetic Completed
  3. Phase 4 Dose Response of a Tubule Occlusion Agent Completed
  4. Phase 3 Evaluation of EXPAREL for Prolonged Postsurgical Analgesia in Subjects Undergoing Third Molar Extraction Completed
  5. Phase 3 Evaluation of the Efficacy and Safety of Diclofenac HPBCD 75mg/ml in Treatment of Pain Following Dental Surgery Completed
  6. Phase 3 Evaluation of the Efficacy and Safety of Diclofenac HPBCD 25, 50 mg/ml in the Treatment of Post-surgical Pain Following Dental Surgery Completed
Show 10 more trials
  1. Phase 2 Study of Long-Acting Acetaminophen in Postoperative Dental Pain Completed
  2. Phase 2 Study of Diclofenac Capsules to Treat Dental Pain Completed
  3. Phase 2 Study of Buprenorphine HCl Buccal Film in the Treatment of Dental Pain Completed
  4. Phase 2 Dental Pain Study of Analgesics in Patients Undergoing Molar Removal Completed
  5. Phase 2 Phase 2 Study of Indomethacin Capsules to Treat Dental Pain Completed
  6. Phase 2 Safety and Efficacy Study of XPF-001 to Treat Pain Following Wisdom Tooth Extraction Completed
  7. Phase 2 Study of Naproxen Capsules to Treat Dental Pain Completed
  8. Phase 2 A Study of Acetaminophen for Post Surgical Dental Pain Completed
  9. Phase 1 The Effects of Potassium Nitrate in Reducing Dentinal Hypersensitivity Completed
  10. N/A Nonpharmacologic Reduction of Periprocedural Distress and Drug Use Completed

Showing the 16 most-cited and recently-updated of 16 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

What the trials found For clinicians

Dental pain: what the trials found

Non-buffered Anesthetic was associated with a significant reduction in pain scores as measured by the Behavior Pain Scale (2.24 vs. 2.61, p=0.005). This intervention did not result in statistically significant changes in heart rate (p=0.775) or diastolic blood pressure (p=0.682).

Diclofenac HPBCD demonstrated a statistically significant reduction in pain intensity (PID) on a 0-100 VAS (36.5 vs. 12.3, p<0.001). However, when administered as a subcutaneous injection (75mg/ml), the difference in pain intensity was not statistically significant (p=0.862).

Bupivacaine liposome was evaluated for opioid-free duration; the percentage of patients remaining opioid-free at 24, 48, and 72 hours remained consistent at 19% and 12% respectively across the study period.

The 5% calcium sodium phosphosilicate toothpaste did not produce statistically significant changes in evaporative air sensitivity (p=0.6674 at 7 days; p=0.3628 at 15 days) or cold water sensitivity (p=0.9759) on a Visual Analog Scale (VAS).

Recent results — preliminary, needs further review

  • Acetaminophen showed significant improvements in Sum of Pain Intensity Difference (SPID24) and Sum of Pain Relief (TOTPAR24) (p=0.0258; p=0.0087).
  • Acetaminophen ER showed significant improvements in Time Weighted Sum of Pain Intensity Difference (SPID 0-10) and Time to Meaningful Pain Relief (p<0.001).
  • Celecoxib 400 mg showed significant results in Total Patient Pain Relief Over 0 to 8 Hours (p<0.001).
  • Naproxen Test showed significant results in Total Pain Relief (TOTPAR) Over 0 to 12 Hours (p<0.001).
  • Diclofenac Test (lower dose) showed significant results in Total Patient Pain Relief Over 0 to 12 Hours (p<0.001).

For the clinician treating this condition

  • Non-buffered Anesthetic is associated with significant reductions in pain scores without significant impacts on heart rate or diastolic blood pressure.
  • Diclofenac HPBCD shows significant pain intensity reduction in certain formulations, though results were not statistically significant in a specific subcutaneous 75mg/ml concentration.
  • Calcium sodium phosphosilicate toothpaste did not demonstrate statistically significant improvements in evaporative or cold water sensitivity at the 7 or 15-day marks.

AI synthesis of 0 cited trials, updated Nov 6, 2026. Informational only — not medical advice; trial data sourced from ClinicalTrials.gov. How we use AI.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.