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Home › Conditions › Dentin Hypersensitivity

Dentin Hypersensitivity

0 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Dentin Hypersensitivity

6 trials tracked for Dentin Hypersensitivity: 2 in phase 3 or 4 and 1 with published results. The most-cited published study has 36 citations.

6Trials tracked
2Phase 3 & 4
0Recruiting
1With published results
Phase distribution
Phase 3 2 Phase 2 1 Other / NA 3
  1. Phase 3 Clinical Efficacy Of BioMin F, Colgate Sensitive Pro-Relief And Sensodyne Rapid Action Dentifrices In DH Completed · 36 cited
  2. Phase 3 The Efficacy of a Toothpaste to Reduce Sensitivity Completed
  3. Phase 2 Study to Characterize the Efficacy of a Dual Active Dentifrice for the Relief of Dentin Hypersensitivity Completed
  4. N/A A Clinical Study to Assess the Effects of Various Dentifrice Technologies on Dentinal Hypersensitivity Completed
  5. N/A A Comparison Study of Hypersensitivity Treatment Completed
  6. N/A Cyanoacrylate and Laser and Dentin Sensitivity Completed

Showing the 6 most-cited and recently-updated of 6 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

What the trials found For clinicians

Dentin Hypersensitivity: what the trials found

Fluoro-Calcium-Phospho-Silicate based dentifrices demonstrated statistically significant reductions in pain response across multiple stimuli. Specifically, these products showed significant percent changes in mean scores for pain response from baseline when tested with Schiff Cold Air Sensitivity Scale (air blast), Visual Analog Scale (mechanical stimulus), and Visual Analog Scale (water jet) 1.

A combination of Triclosan, Silicon dioxide, and fluoride was found to significantly reduce hypersensitivity. This was evidenced by significant reductions in tactile hypersensitivity (Yeaple Probe) and air blast hypersensitivity at the 4-week mark 2.

Recent results — preliminary, needs further review

  • Potassium Nitrate showed a reduction in mean Schiff Sensitivity Scores from baseline at Day 3 and Day 7, but these findings are not yet corroborated 3.
  • 3M Clinpro Fluoride Aqueous Solution showed a reduction in pain from baseline at 24 hours, 7 days, and 21 days post-application, but these findings are not yet corroborated 4.
  • Stannous fluoride toothpaste was evaluated for dentin hypersensitivity, but results are not yet corroborated 5.
  • Cyanoacrylate was evaluated for dentin hypersensitivity, but results are not yet corroborated 6.

For the clinician treating this condition

  • Fluoro-Calcium-Phospho-Silicate based dentifrices are effective in reducing pain responses across air blast, mechanical, and water jet stimuli 1.
  • A combination of Triclosan, Silicon dioxide, and fluoride provides significant reduction in both tactile and air blast hypersensitivity 2.

AI synthesis of 6 cited trials, updated Sep 23, 2026. Informational only — not medical advice; trial data sourced from ClinicalTrials.gov. How we use AI.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
No published articles yet for this condition. Check back soon.