Tryptophan metabolism pathways like IDO and TDO2 influence immune cell function in end-stage liver disease
New research explores how liver enzymes impact transplant immunity
This systematic review examines the role of tryptophan metabolism, specifically the kynurenine pathway and AhR signaling, in immune toleranc…
Scientists are looking at how specific pathways in the body might help patients with end-stage liver disease accept transplants.
FIPS AUC 0.821 outperforms MELD scores for 90-day mortality prediction in TIPS for ascites
New score outperforms MELD for predicting death after TIPS for bleeding
This meta-analysis of 5,180 patients undergoing TIPS for ascites or gastroesophageal bleeding compared MELD-based scores and the FIPS index …
A new scoring system called FIPS may better predict 90-day death risk after TIPS for bleeding than older MELD scores.
Hepatologist-led palliative care matches specialist care for cirrhosis and cancer patients
Trained liver doctors provided care that matched specialists for patients with serious liver disease
A US trial found hepatologist-delivered palliative care noninferior to specialist care for improving quality of life in advanced liver disea…
Patients with advanced liver disease saw similar quality of life improvements when cared for by trained liver doctors versus specialists. Bo…
Narrative review on sepsis in end-stage liver disease and acute-on-chronic liver failure
Patients with severe liver disease and sepsis face high risks and need careful care plans
This narrative review synthesizes evidence on sepsis in patients with end-stage liver disease and acute-on-chronic liver failure. It describ…
People with advanced liver sickness and sepsis often have weak immune systems and get hard-to-treat infections. Doctors say new treatments l…
Research across Cirrhosis
Related studies from across the Cirrhosis family.
Ultrasound imaging serves as a versatile diagnostic tool for multiple diabetes-related complications
Ultrasound Imaging Helps Detect Various Diabetes Related Complications
This meta-analysis evaluates the diagnostic role of ultrasound imaging in identifying various complications of diabetes mellitus. The analys…
Ultrasound imaging can help doctors identify and monitor several different complications caused by diabetes, including nerve and heart issue…
Salvia miltiorrhiza components show potential for hepatocyte protection and hepatic stellate cell control
Salvia miltiorrhiza shows potential for treating liver fibrosis
This narrative review examines the roles of Salvia miltiorrhiza, salvianolic acid A, and tanshinones in liver fibrosis. The review suggests …
New research explores how compounds in Salvia miltiorrhiza might protect liver cells and control the scarring process in liver fibrosis.
cGAS-STING pathway serves as a central axis for innate immune activation in MASLD and HCC
New research identifies a key immune pathway in fatty liver disease
This systematic review explores the role of the cGAS-STING pathway in metabolic dysfunction-associated steatotic liver disease and hepatocel…
A specific immune pathway called cGAS-STING may play a major role in how fatty liver disease progresses and leads to serious complications.
Hepatic macrophage metabolic reprogramming and bidirectional signaling dictate the balance between liver injury and regeneration
New research identifies how liver cells communicate during chronic disease
This systematic review synthesizes the role of hepatic macrophages in metabolic dysfunction-associated steatotic liver disease, alcohol-asso…
New research reveals how specific immune cells in the liver switch between causing inflammation and repairing tissue damage.
Lactylation Targeting Shows Preclinical Anti-Fibrotic Potential in Liver Fibrosis
New Research Identifies Potential Targets for Liver Fibrosis Treatment
This narrative review examines lactylation, particularly H3K18La, as a mechanistic driver of liver fibrosis and evaluates preclinical interv…
Scientists have identified specific biological pathways and natural compounds that may help slow down the progression of liver fibrosis in e…
Transcriptomic analysis identifies 846 genes and key pathways associated with MASLD fibrosis progression
New data reveals how liver scarring progresses in fatty liver disease
This meta-analysis of hepatic transcriptomic data in approximately 1000 patients identifies 846 genes associated with MASLD fibrosis progres…
Researchers identified specific genes and cell changes that drive liver scarring in patients with metabolic dysfunction-associated steatotic…
Dioscin shows therapeutic potential for various liver disorders including MASLD and hepatocellular carcinoma
Plant Compound Dioscin Shows Promise For Liver Disease
This systematic review evaluates the hepatoprotective effects and pharmacokinetics of Dioscin in various liver diseases. The review conclude…
A plant compound called Dioscin may help protect the liver, but human evidence is still missing and high doses carry risks.
Phase 2 Trial Evaluating Zalfermin and Semaglutide Combinations for Metabolic Dysfunction Associated Steatohepatitis
Trial Shows Semaglutide May Impact Liver Fibrosis in MASLD
A 52-week trial assessed whether zalfermin combined with semaglutide improves liver fibrosis in patients with advanced steatohepatitis.
A new trial suggests semaglutide may improve liver fibrosis in patients with MASLD, while other combinations did not show significant result…
Narrative review explores macrophage reprogramming for liver fibrosis and MASH
Scientists explore new ways to reprogram liver cells to heal damaged tissue and stop scarring
This narrative review summarizes macrophage reprogramming strategies for liver fibrosis and MASH. Approaches include gene modulation, pharma…
A recent review looks at fresh methods to change how liver immune cells behave. These changes could help heal liver scarring and improve hea…
Systematic review and meta-analysis evaluates ML and DL models for diagnosing MASH and fibrosis
AI models help doctors spot liver disease with high accuracy
This systematic review and meta-analysis of 106 studies assessed machine learning (ML) and deep learning (DL) models for diagnosing metaboli…
New computer tools can diagnose fatty liver disease and scarring with impressive accuracy. This review analyzed data from many studies to se…
L-taurine shows no overall fatigue benefit in decompensated cirrhosis but may help non-anemic patients
Taurine for cirrhosis fatigue fails overall but helps one group
This randomized controlled trial in 220 adults with decompensated cirrhosis found no significant difference in fatigue scores with L-taurine…
Taurine did not reduce fatigue in most cirrhosis patients, but those without anemia saw meaningful improvement, suggesting a targeted approa…
Influenza vaccine induces stronger immune responses in liver cirrhosis patients
Flu Shot Works Better in Advanced Liver Disease
This prospective observational study found that patients with liver cirrhosis mount stronger humoral and cell-mediated immune responses to t…
You’re living with cirrhosis. Every cold feels dangerous.