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Home › Conditions › Fragile X Syndrome

Fragile X Syndrome

Part of X-Linked Intellectual Disability

1 published article · Updated continuously

Clinical Trial Landscape

Clinical Trials for Fragile X Syndrome

18 trials tracked for Fragile X Syndrome: 3 in phase 3 or 4 and 3 with published results. The most-cited published study has 65 citations.

18Trials tracked
3Phase 3 & 4
0Recruiting
3With published results
Phase distribution
Phase 4 2 Phase 3 1 Phase 2 12 Phase 1 1 Other / NA 2
  1. Phase 4 Riluzole in Fragile X Syndrome Completed · 65 cited
  2. Phase 3 Clinical Study Of caNNabidiol in childrEn and adolesCenTs With Fragile X (CONNECT-FX) Completed · 65 cited
  3. Phase 4 Combining Lovastatin and a Parent-Implemented Language Intervention for Fragile X Syndrome Completed · 56 cited
  4. Phase 2 AFQ056 for Language Learning in Children With FXS Completed
  5. Phase 2 Ganaxolone Treatment in Children With Fragile X Syndrome Completed
  6. Phase 2 Trial of Sertraline to Treat Children With Fragile X Syndrome Completed
Show 12 more trials
  1. Phase 2 Acamprosate in Youth With Fragile X Syndrome Completed
  2. Phase 2 A 2-Period Crossover Study of BPN14770 in Adults Males With Fragile X Syndrome Completed
  3. Phase 2 Double-blind Placebo Controlled Study of Oxytocin in Fragile X Syndrome Completed
  4. Phase 2 A Prospective Open-label Study of Aripiprazole in Fragile X Syndrome Completed
  5. Phase 2 Randomized Controlled Study of Donepezil in Fragile X Syndrome Completed
  6. Phase 2 ERG/5-HTP in Fragile X Syndrome (FXS) Completed
  7. Phase 2 Safety and Efficacy of AFQ056 in Adolescent Patients With Fragile X Syndrome Completed
  8. Phase 2 Study of SPG601 in Adult Men With Fragile X Syndrome Completed
  9. Phase 2 Safety, Tolerability and Efficacy Study of STX209 in Subjects With Fragile X Syndrome Completed
  10. Phase 1 Neurophysiological and Acute Pharmacological Studies in FXS Patients Completed
  11. N/A Add-on Pilot Trial of Minocycline to Treat Fragile X Syndrome Completed
  12. N/A Trial of Minocycline to Treat Children With Fragile X Syndrome Completed

Showing the 18 most-cited and recently-updated of 18 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Arbaclofen Phase 3 Trials Establish Clinically Meaningful Change Thresholds in Fragile X Syndrome
Drug Pipeline Phase III
Arbaclofen Phase 3 Trials Establish Clinically Meaningful Change Thresholds in Fragile X Syndrome New Rules for Measuring Behavior Change in Fragile X
A review of two Phase 3 trials in 278 individuals with Fragile X Syndrome (aged 5-50 years) established clinically meaningful change thresho…
Imagine a parent watching their child struggle with daily routines.
Apr 24, 2026