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Home › Conditions › Frozen shoulder

Frozen shoulder

0 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Frozen shoulder

5 trials tracked for Frozen shoulder: 2 in phase 3 or 4 and 2 with published results. The most-cited published study has 407 citations.

5Trials tracked
2Phase 3 & 4
0Recruiting
2With published results
Phase distribution
Phase 4 1 Phase 3 1 Phase 2 3
  1. Phase 4 Intra-articular Doxycycline: A Novel Treatment of Adhesive Capsulitis Completed · 407 cited
  2. Phase 3 The Anti-Freaze-F Study- "Anti-TNF for Treatment of Frozen Shoulder - a Feasibility Study" Completed · 4 cited
  3. Phase 2 AA4500 for the Treatment of Adhesive Capsulitis of the Shoulder Completed
  4. Phase 2 Clinical Study for the Treatment of Adhesive Capsulitis of the Shoulder Completed
  5. Phase 2 Safety and Efficacy of EN3835 in Participants With Frozen Shoulder Completed

Showing the 5 most-cited and recently-updated of 5 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

What the trials found For clinicians

Frozen shoulder: what the trials found

A single-patient phase 4 trial evaluated methylprednisolone injectable product for frozen shoulder, but no outcome data were reported, limiting conclusions 1. A small phase 3 trial of adalimumab injection (N=9) reported SPADI scores of 70.8, 55.4, 40.1, and 45.8 at successive time points, suggesting some improvement, but the lack of a comparator and small sample size preclude definitive efficacy claims 2.

Recent results — preliminary, needs further review

  • In a phase 2 trial (N=198), EN3835 showed no significant difference in ASES composite score change from baseline at day 95 compared to control (41.35 vs 41.16, p=0.659), indicating no benefit over placebo 3.
  • Another phase 2 trial (N=50) of AA4500 reported ASES composite score changes from baseline to day 92 of 26.9, 41.6, 35.9, 19.3, and 9.9 across dose groups, but without statistical comparison, efficacy remains unconfirmed 4.
  • A phase 2 trial (N=322) of collagenase clostridium histolyticum was listed but no outcome data were provided, so its findings are not yet assessable 5.

For the clinician treating this condition

  • Evidence for methylprednisolone injectable product is limited to a single-patient trial with no reported outcomes, so its efficacy is not established 1.
  • Adalimumab showed numerical improvement in SPADI scores in a small trial, but the lack of control group and small N limit interpretation 2.
  • EN3835 failed to demonstrate superiority over control in a larger trial, suggesting it may not be effective for frozen shoulder 3.

AI synthesis of 5 cited trials, updated Aug 8, 2026. Informational only — not medical advice; trial data sourced from ClinicalTrials.gov. How we use AI.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
No published articles yet for this condition. Check back soon.