Research across Osteoarthritis
Related studies from across the Osteoarthritis family.
Metabolic reprogramming of chondrocytes through impaired oxidative phosphorylation contributes to articular cartilage collapse
Cells' energy crisis may drive osteoarthritis cartilage collapse
This systematic review synthesizes literature regarding metabolic reprogramming in chondrocytes during osteoarthritis. The authors conclude …
Osteoarthritis may be fueled by a cellular energy crisis, not just wear and tear. A new review suggests targeting metabolism could lead to n…
Gut microbiota dysbiosis linked to osteoarthritis pathology in preclinical and human studies
Gut health may play a role in osteoarthritis joint pain
This narrative review synthesizes evidence linking gut microbiota dysbiosis to osteoarthritis. Human studies show OA-associated changes in m…
New research suggests that imbalances in gut bacteria could contribute to cartilage damage and inflammation in people with osteoarthritis.
Chronic ACL deficiency increases risk of moderate to severe arthritis compared to reconstruction
ACL injuries and surgery impact long term risk of arthritis
This meta-analysis of matched cohort studies evaluates the risk of osteoarthritis in patients with chronic anterior cruciate ligament (ACL) …
People with torn ACL ligaments face higher risks of severe joint arthritis over time, especially if they undergo certain surgical procedures…
Peripheral mechanisms like proton-sensing channels and neurovascular remodeling contribute to pain in osteoarthritis
New research explores why osteoarthritis pain becomes hard to treat
This narrative review explores the complex pathophysiology of osteoarthritis pain, highlighting roles such as proton-sensing nociceptor acti…
Pain from osteoarthritis may be driven by nerve changes and inflammation, making it harder for doctors to manage as the condition progresses…
Circadian misalignment associated with increased risk of osteoporosis, sarcopenia, and osteoarthritis
Circadian Disruption Linked to Bone and Muscle Loss
This narrative review examines the impact of circadian disruption on musculoskeletal health, specifically regarding bone loss, muscle protei…
Shift work and irregular eating may harm bones and muscles. A new review explains how.
NF-κB signaling integrates mechanical stress and immunity in osteoarthritis joint degeneration
New review reveals how inflammation drives osteoarthritis joint damage
This narrative review synthesizes evidence on NF-κB signaling as a central hub integrating mechanical stress, innate immunity, and metabolic…
A new review explains how mechanical stress, immune signals, and metabolism combine to drive osteoarthritis, pointing to smarter treatments.
Cartilage Thickness Score shows higher values in future knee osteoarthritis cases in a cohort study
New cartilage score predicts knee osteoarthritis onset and progression in study cohorts
This observational cohort study in the Osteoarthritis Initiative found that the Cartilage Thickness Score was higher in individuals who late…
A new cartilage score predicts who will develop knee osteoarthritis or need a replacement before symptoms appear.
Gut microbiome metabolites regulate bone health via SCFAs, bile acids, and tryptophan pathways
Multi-omics approaches reveal new links between gut microbes and bone health
This narrative review synthesizes evidence that gut microbiome metabolites—SCFAs, bile acids, and tryptophan derivatives—regulate bone remod…
A narrative review suggests gut microbes may influence bone conditions like osteoporosis and osteoarthritis through specific metabolic pathw…
Umbrella review suggests curcumin may offer comparable efficacy and better tolerability than NSAIDs for osteoarthritis
Curcumin shows promise for osteoarthritis pain with fewer side effects than NSAIDs
This umbrella review synthesizes evidence on curcumin formulations versus non-steroidal anti-inflammatory drugs (NSAIDs) for osteoarthritis.…
An umbrella review suggests curcumin may help osteoarthritis pain and function as well as NSAIDs while offering a more favorable tolerabilit…
Review of senescence-associated secretory phenotype in aging osteoarthritis and disc degeneration
Aging cells release signals that may worsen bone and joint disease in older adults
This narrative review examines the senescence-associated secretory phenotype (SASP) in aging populations with osteoarthritis, intervertebral…
A review suggests aging cell signals could drive bone and joint problems. This insight helps doctors understand why these conditions worsen …
Systematic review of Dendrobium phenanthrene bioactivity across multiple disease models
Scientists found many plant chemicals that fight cancer and help diabetes in lab tests
This systematic review evaluates the bioactivity of 158 phenanthrene metabolites isolated from 53 Dendrobium taxa. The authors note that 64 …
A review of plant chemicals from Dendrobium plants shows strong activity against cancer and diabetes in lab studies. Most results come from …
Systematic review and meta-analysis of olive-derived compounds for osteoarthritis pain
Olive Oil Compounds Ease Knee Pain Better Than Expected
This systematic review and meta-analysis evaluated orally and/or topically administered olive-derived extracts or isolated bioactive compoun…
• Olive compounds cut knee pain modestly in studies • Helps adults with osteoarthritis or degenerative joint pain • Only three small trials …