Research across Osteoarthritis
Related studies from across the Osteoarthritis family.
NF-κB signaling integrates mechanical stress and immunity in osteoarthritis joint degeneration
New review reveals how inflammation drives osteoarthritis joint damage
This narrative review synthesizes evidence on NF-κB signaling as a central hub integrating mechanical stress, innate immunity, and metabolic…
A new review explains how mechanical stress, immune signals, and metabolism combine to drive osteoarthritis, pointing to smarter treatments.
Cartilage Thickness Score shows higher values in future knee osteoarthritis cases in a cohort study
New cartilage score predicts knee osteoarthritis onset and progression in study cohorts
This observational cohort study in the Osteoarthritis Initiative found that the Cartilage Thickness Score was higher in individuals who late…
A new cartilage score predicts who will develop knee osteoarthritis or need a replacement before symptoms appear.
Gut microbiome metabolites regulate bone health via SCFAs, bile acids, and tryptophan pathways
Multi-omics approaches reveal new links between gut microbes and bone health
This narrative review synthesizes evidence that gut microbiome metabolites—SCFAs, bile acids, and tryptophan derivatives—regulate bone remod…
A narrative review suggests gut microbes may influence bone conditions like osteoporosis and osteoarthritis through specific metabolic pathw…
Umbrella review suggests curcumin may offer comparable efficacy and better tolerability than NSAIDs for osteoarthritis
Curcumin shows promise for osteoarthritis pain with fewer side effects than NSAIDs
This umbrella review synthesizes evidence on curcumin formulations versus non-steroidal anti-inflammatory drugs (NSAIDs) for osteoarthritis.…
An umbrella review suggests curcumin may help osteoarthritis pain and function as well as NSAIDs while offering a more favorable tolerabilit…
Review of senescence-associated secretory phenotype in aging osteoarthritis and disc degeneration
Aging cells release signals that may worsen bone and joint disease in older adults
This narrative review examines the senescence-associated secretory phenotype (SASP) in aging populations with osteoarthritis, intervertebral…
A review suggests aging cell signals could drive bone and joint problems. This insight helps doctors understand why these conditions worsen …
Systematic review of Dendrobium phenanthrene bioactivity across multiple disease models
Scientists found many plant chemicals that fight cancer and help diabetes in lab tests
This systematic review evaluates the bioactivity of 158 phenanthrene metabolites isolated from 53 Dendrobium taxa. The authors note that 64 …
A review of plant chemicals from Dendrobium plants shows strong activity against cancer and diabetes in lab studies. Most results come from …
Systematic review and meta-analysis of olive-derived compounds for osteoarthritis pain
Olive Oil Compounds Ease Knee Pain Better Than Expected
This systematic review and meta-analysis evaluated orally and/or topically administered olive-derived extracts or isolated bioactive compoun…
• Olive compounds cut knee pain modestly in studies • Helps adults with osteoarthritis or degenerative joint pain • Only three small trials …
Total hip arthroplasty with rehabilitation improves WOMAC and HHS scores versus conservative exercise in hip osteoarthritis
Hip replacement beats exercise for severe hip arthritis
This single-centre randomized controlled trial enrolled 120 patients with moderate-to-severe hip osteoarthritis (Kellgren-Lawrence grades 2 …
A new trial finds hip replacement plus rehab dramatically outperforms exercise alone for moderate-to-severe hip osteoarthritis.
Review of engineered exosomes for knee osteoarthritis notes significant limitations and lack of efficacy data
Engineered Exosomes Could Change How We Treat Knee Pain
This narrative review examines the potential of engineered exosomes for treating knee osteoarthritis.
New engineered cell parts show promise for stopping knee arthritis damage in early tests before human trials.
Intra-articular adipose-derived cell therapies reduce pain and improve function in knee osteoarthritis without serious adverse events
Knee Pain Relief That Lasts? This Shot Could Be It
A systematic review and meta-analysis of nineteen randomized controlled trials evaluated intra-articular adipose-derived cell therapies for …
This new treatment could help people with stubborn knee pain finally walk without wincing.
Narrative review explores exosomal non-coding RNAs in osteoarthritis pathogenesis and therapy
Tiny Messengers in Your Joints Could Change Osteoarthritis Care
This narrative review summarizes the role of exosomal non-coding RNAs in osteoarthritis.
Scientists are learning how to use your body’s own tiny messengers to calm inflamed joints and potentially slow osteoarthritis.
Genomic analysis identifies tissue-specific causal genes for osteoarthritis in meniscus and cartilage
Genetic study links specific genes to knee osteoarthritis in meniscus and cartilage
This research article uses genomic analysis on human meniscus and cartilage tissue to identify genetic associations with osteoarthritis.
Researchers identified 75 genes tied to osteoarthritis risk in knee tissues, highlighting tissue-specific genetic patterns that could guide …