Research across Osteoarthritis
Related studies from across the Osteoarthritis family.
Coumarins and derivatives may protect musculoskeletal health by modulating inflammatory and oxidative mediators
Coumarins may protect bone and joint health in several diseases
This systematic review examines the role of coumarins and their derivatives in managing musculoskeletal diseases including osteoporosis, rhe…
Coumarins and their derivatives may slow the progression of bone and joint diseases by targeting inflammation and specific cellular pathways…
Gut microbiota-targeted interventions reduce pain and function scores in patients with osteoarthritis
Gut health treatments may reduce pain for osteoarthritis patients
This meta-analysis of 18 trials involving 2,080 adults with osteoarthritis found that probiotics, prebiotics, and synbiotics significantly r…
Targeting the gut with probiotics and prebiotics may help ease pain and improve physical function for people living with osteoarthritis.
Therapeutic extracellular vesicles may curb inflammation and restore mitochondrial quality in osteoarthritis
Tiny particles may offer new hope for osteoarthritis treatment
This systematic review examines the role of extracellular vesicles (EVs) in osteoarthritis, identifying both pathological and therapeutic EV…
Small particles called extracellular vesicles could stop the cycle of joint damage and inflammation in people with osteoarthritis.
Immune signaling and bidirectional neuropeptide release drive nociceptor sensitization in osteoarthritis pain
Immune Signaling and Nerve Activity Drive Osteoarthritis Pain
This mini review explores the mechanisms of synovial inflammation and immune signaling in osteoarthritis. It describes how macrophages, T ce…
New research highlights how immune cells and nerve signals work together to create and amplify chronic pain in people with osteoarthritis.
Interactive remote rehabilitation shows no significant advantage over conventional rehabilitation for post-TKA patients
Interactive remote rehabilitation shows mixed results for knee replacement patients
This meta-analysis of randomized controlled trials involving 2607 adults post-total knee arthroplasty found that interactive remote rehabili…
New research into interactive remote rehabilitation for knee replacements shows it may not offer significant advantages over traditional in-…
Icariin improves pain and cartilage scores in murine osteoarthritis, meta-analysis finds
Icariin Shows Potential to Reduce Osteoarthritis Pain in Mice
This meta-analysis of 13 preclinical studies (238 murine subjects) found that Epimedium-derived botanical metabolites, including icariin, si…
A review of studies on mice suggests that icariin, a compound from the Epimedium plant, may reduce inflammation and pain markers in osteoart…
Multi-trait genome-wide association studies identify 66 novel genetic associations in osteoarthritis using the Trident framework
New genetic analysis finds 66 hidden osteoarthritis signals
This meta-analysis evaluates the use of the Trident framework and Combined-GWAS (C-GWAS) method to identify genetic markers for osteoarthrit…
A new genetic method uncovered 66 hidden osteoarthritis signals, offering fresh clues about the condition and potential new targets for trea…
Inflammaging and immunosenescence emerge as key mechanistic axes in osteoarthritis pathogenesis
Aging and inflammation drive the progression of osteoarthritis
This narrative review synthesizes evidence that inflammaging and immunosenescence are central to osteoarthritis pathogenesis, linking aging,…
New research highlights how aging cells and chronic inflammation work together to break down joint tissue in people with osteoarthritis.
Exosomes are safe for knee osteoarthritis but show no superiority over placebo in one trial
Exosomes for knee arthritis: safe but no better than placebo
This systematic scoping review synthesizes evidence on orthobiologics including platelet-rich plasma, cytokine-rich serum, and extracellular…
A review finds exosome injections for knee osteoarthritis are safe, but one trial shows no advantage over placebo.
Telemedicine modalities may achieve comparable outcomes to conventional follow-up for uncomplicated total joint arthroplasty
Telemedicine may offer similar results for hip and knee replacements
This mini review synthesizes evidence regarding telemedicine modalities, including video consultations and telerehabilitation, for patients …
New evidence suggests that using video calls and remote monitoring for joint replacement recovery can match the quality of traditional in-pe…
Mechanical loading induces innate immune reprogramming and mitochondrial danger signals in osteoarthritis models
Mechanical Loading May Influence Immune Responses in Osteoarthritis
This mini review explores the role of mechanical loading in driving innate immune reprogramming and mitochondrial stress in osteoarthritis. …
New research explores how physical loading affects immune cells and mitochondria in joints affected by osteoarthritis.
Ion channels and signaling pathways form a mechanobiological-immunological framework for osteoarthritis progression
New Framework Links Ion Channels to Osteoarthritis
This narrative review synthesizes the roles of ion channels and key signaling pathways in osteoarthritis pathology. It proposes an integrate…
A new review maps how ion channels and signaling pathways interact in osteoarthritis, offering a theoretical basis for future multi-target t…