Polymyxins in resistant Gram-negative infections: 22% all-cause mortality, 10% nephrotoxicity
Polymyxins For Kids: 22% Mortality In Resistant Infections
This meta-analysis pooled data from 1,152 hospitalized children with documented or suspected resistant Gram-negative infections treated with…
In hospitalized children with resistant Gram-negative infections, 22% died and 65% improved on polymyxin therapy.
Beta-lactam/beta-lactamase inhibitor therapy reduces all-cause mortality in multidrug-resistant Gram-negative infections
Combination Therapy Shows Better Outcomes for Gram-Negative Infections
This systematic review and network meta-analysis of 1760 patients found that beta-lactam/beta-lactamase inhibitor therapy significantly redu…
Combining certain antibiotics may lower death rates and reduce kidney damage for patients with multidrug-resistant Gram-negative infections.
TLR4 Asp299Gly polymorphism associated with increased infection susceptibility (OR 2.05) and mortality (HR 1.78)
Genetic variations linked to higher risk of severe infections
This systematic review and meta-analysis of 9,196 individuals with TLR4 polymorphisms found that the Asp299Gly variant is associated with si…
Specific genetic markers in the TLR4 gene may increase susceptibility and mortality for those with certain gram-negative bacterial infection…