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Heart Valve Diseases

Subtypes of Heart Valve Diseases

Mitral Regurgitation 2 Mitral valve prolapse 2 Tricuspid Regurgitation 2

7 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Heart Valve Diseases

14 trials tracked for Heart Valve Diseases: 3 in phase 3 or 4 and 2 with published results. The most-cited published study has 282 citations.

14Trials tracked

3Phase 3 & 4

0Recruiting

2With published results

Phase distribution

Phase 3 3 Phase 2 1 Other / NA 10

Phase 3 Comparison of a Rivaroxaban-based Strategy With an Antiplatelet-based Strategy Following Successful TAVR for the Prevention of Leaflet Thickening and Reduced Leaflet Motion as Evaluated by Four-dimensional, Volume-rendered Computed Tomography (4DCT) Completed · 282 cited
Phase 3 SONOlysis in Risk REduction of Symptomatic and Silent Brain infarCtions dUring Cardiac surgEry Completed · 6 cited
Phase 3 Atrovastatin for Preventing Atrial Fibrillation Following Open Cardiac Valve Repair Completed
Phase 2 Prolongation of the Interval Between Monitoring of Warfarin in Stable Patients Completed
N/A Feasibility Study of the Tendyne Mitral Valve System in Mitral Annular Calcification Completed
N/A Patients Perception of Mechanical Heart Valve Sounds: Psychoacoustics and Quality of Life Completed

Show 8 more trials

N/A Medtronic HAMMOCK Post Approval Study Completed
N/A Clinical Investigation Of The Mitroflow Aortic Pericardial Heart Valve Completed
N/A A Post-Marketing Study for On Label Evaluation of the GE Vscan Ultrasound Imaging System Completed
N/A The Improving ATTENDance to Cardiac Rehabilitation Trial Completed
N/A NeoChord TACT Post-Market Surveillance Registry Completed
N/A ATS 3f Enable(tm) Aortic Bioprosthesis, Model 6000 Completed
N/A TRI-REPAIR: TrIcuspid Regurgitation RePAIr With CaRdioband Transcatheter System Completed
N/A Post-Approval Study Protocol of the St. Jude Medical Trifecta Valve Completed

Showing the 14 most-cited and recently-updated of 14 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

What the trials found For clinicians

Heart Valve Diseases: what the trials found

Acetylsalicylic acid has been shown to significantly impact mechanical valve function, with a statistically significant reduction in the rate of patients presenting with at least one prosthetic leaflet having over 50% motion reduction as measured by cardiac 4DCT-scan (11 vs. 2; p=0.01) ¹. Additionally, it was associated with a significant difference in aortic transvalvular mean pressure gradient as determined by transthoracic echocardiography (10 vs. 10; p=0.01) ¹.

Sonolysis has been evaluated for its impact on neurological outcomes, specifically regarding the number of participants with new brain infarction in the monitored MCA territory detected via MRI (8; 16; 52; 44; p=<0.05) ². Atorvastatin was also investigated in a Phase 3 trial for this condition ³.

Recent results — preliminary, needs further review

The HYCR program showed higher rates of patients completing 36 cardiac rehabilitation sessions within 6 months compared to traditional CBCR (58.5% vs. 50.7%) ⁵.
Quality of life scores using the Dartmouth COOP were reported as -3.9 for HYCR and -3.4 for CBCR ⁵.

For the clinician treating this condition

Acetylsalicylic acid is associated with improved prosthetic leaflet motion and significant differences in aortic transvalvular mean pressure gradients ¹.
Sonolysis has demonstrated a statistically significant impact on the incidence of new brain infarctions in the MCA territory ².

AI synthesis of 4 cited trials, updated Jun 29, 2026. Informational only — not medical advice; trial data sourced from ClinicalTrials.gov. How we use AI.