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Home › Conditions › Mitral Regurgitation

Mitral Regurgitation

Part of Heart Valve Diseases

2 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Mitral Regurgitation

13 trials tracked for Mitral Regurgitation: 1 in phase 3 or 4.

13Trials tracked
1Phase 3 & 4
0Recruiting
0With published results
Phase distribution
Phase 3 1 Phase 2 1 Other / NA 11
  1. Phase 3 Molecular Mechanisms of Volume Overload-Aim 1(SCCOR in Cardiac Dysfunction and Disease) Completed
  2. Phase 2 Feasibility Study of a Percutaneous Mitral Valve Repair System. Completed
  3. N/A Feasibility Study of the Tendyne Mitral Valve System in Mitral Annular Calcification Completed
  4. N/A The Right Ventricular Pulmonary Circulation Continuum in Mitral Valve Disease Study Completed
  5. N/A Pleth Variability Index (PVI) as a Measure of Volume Status During Transcatheter Mitral Valve Repair Completed
  6. N/A 5-Year Follow-Up Safety and Performance Evaluation of the Medtentia Annuloplasty Ring in Adults Completed
Show 7 more trials
  1. N/A EVEREST II Pivotal Study High Risk Registry (HRR) Completed
  2. N/A Cardioband With Transfemoral Delivery System Completed
  3. N/A Pivotal Study of a Percutaneous Mitral Valve Repair System Completed
  4. N/A MitraClip China PMS Completed
  5. N/A Real World Expanded Multicenter Study of the MitraClip® System (REALISM) Completed
  6. N/A MitraClip NT System Post-marketing Surveillance Study - Japan Completed
  7. N/A The MitraClip® EXPAND Study of the Next Generation of MitraClip® Devices Completed

Showing the 13 most-cited and recently-updated of 13 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Impact of Mitral Prosthesis-Patient Mismatch on Mortality and Outcomes After Valve Replacement
Cardiology Meta-analysis
Impact of Mitral Prosthesis-Patient Mismatch on Mortality and Outcomes After Valve Replacement Mitral valve mismatch increases death and hospital risk after surgery
Mitral prosthesis-patient mismatch significantly increases all-cause mortality and heart failure hospitalizations in patients following mitr…
A size mismatch between a heart valve and the patient can lead to more heart failure hospitalizations and higher death rates.
Jul 1, 2026
M-TEER reduces heart failure hospitalization risk across all health status levels in mitral regurgitation
Cardiology RCT
M-TEER reduces heart failure hospitalization risk across all health status levels in mitral regurgitation Heart Valve Repair Improves Symptoms in Heart Failure Patients
This RCT subgroup analysis found that mitral transcatheter edge-to-edge repair (M-TEER) reduced the risk of cardiovascular death or heart fa…
A study found that mitral valve repair with MitraClip improved symptoms and reduced hospitalizations in heart failure patients with mitral r…
May 19, 2026

Research across Heart Valve Diseases

Related studies from across the Heart Valve Diseases family.

Omics approaches offer theoretical basis for new diagnostic markers and targeted therapeutic strategies in mitral valve disease management
Cardiology Sys. Review
Omics approaches offer theoretical basis for new diagnostic markers and targeted therapeutic strategies in mitral valve disease management New Clues Emerge About Common Heart Valve Problems
This narrative review explores how omics approaches, including genomics and proteomics, could revolutionize the understanding of mitral valv…
Hidden biological signals in heart valve tissue may lead to earlier detection and better treatments for mitral valve disease.
Frontiers May 15, 2026
Transcatheter valve replacement improves outcomes in severe tricuspid regurgitation
Cardiology RCT
Transcatheter valve replacement improves outcomes in severe tricuspid regurgitation New Valve Fix Cuts Hospital Stays for Severe Heart Leak Patients
A randomized trial shows EVOQUE TTVR plus medical therapy outperforms medical therapy alone for severe tricuspid regurgitation, improving va…
A new minimally invasive valve replacement slashes hospital stays for severe heart leak patients especially those with the worst cases new l…
May 5, 2026
GWAS meta-analysis identifies 89 loci for mitral valve prolapse and genetic links to hypertrophic cardiomyopathy
Cardiology Meta-analysis
GWAS meta-analysis identifies 89 loci for mitral valve prolapse and genetic links to hypertrophic cardiomyopathy New DNA Clues Link Heart Valve to Dangerous Rhythms
This meta-analysis of genome-wide association studies (GWAS) evaluated genetic factors in over 2.2 million individuals, including 21,517 cas…
Imagine your heart has a tiny door that sometimes swings too wide.
medRxiv Apr 14, 2026
Autologous pericardial annuloplasty linked to lower TR recurrence in rheumatic heart disease
Cardiology Cohort
Autologous pericardial annuloplasty linked to lower TR recurrence in rheumatic heart disease Study compares two surgical techniques for heart valve repair in rheumatic heart disease
A retrospective cohort study of 251 RHD patients undergoing tricuspid annuloplasty found that autologous pericardial soft-ring annuloplasty …
Using a patient's own tissue to repair a leaky heart valve in rheumatic disease kept the valve working better than artificial rings at four …
Frontiers Apr 1, 2026