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Home › Conditions › hemophagocytic lymphohistiocytosis

Hemophagocytic lymphohistiocytosis

Part of Histiocytosis, Non-Langerhans-Cell

5 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for hemophagocytic lymphohistiocytosis

9 trials tracked for hemophagocytic lymphohistiocytosis: 4 in phase 3 or 4 and 1 with published results. The most-cited published study has 505 citations.

9Trials tracked
4Phase 3 & 4
0Recruiting
1With published results
Phase distribution
Phase 4 1 Phase 3 3 Phase 2 4 Other / NA 1
  1. Phase 3 A Study for Long-term Follow-up of Hemophagocytic Lymphohistiocytosis (HLH) Participants Who Received Treatment With Emapalumab (NI-0501), an Anti-interferon Gamma Monoclonal Antibody Completed · 505 cited
  2. Phase 4 A Post-authorization Study to Describe the Safety and Efficacy of Emapalumab for the Treatment of pHLH in Treatment Experienced Chinese Patients Completed
  3. Phase 3 Study to Assess the Efficacy and Safety of Emapalumab in Primary Haemophagocytic Lymphohistiocytosis Completed
  4. Phase 3 Evaluate Efficacy, Safety and Tolerability, PK and PD of Emapalumab in Children and Adults With MAS in Still's or SLE Completed
  5. Phase 2 Stem Cell Transplant for Immunologic or Histiocytic Disorders Completed
  6. Phase 2 Reduced Intensity Conditioning for Hemophagocytic Syndromes or Selected Primary Immune Deficiencies (BMT CTN 1204) Completed
Show 3 more trials
  1. Phase 2 Hybrid Immunotherapy for Hemophagocytic LymphoHistiocytosis Completed
  2. Phase 2 A Study to Investigate the Safety and Efficacy of Emapalumab, an Anti-IFN-gamma mAb in Patients With Systemic Juvenile Idiopathic Arthritis (sJIA) or Adult-onset Still's Disease (AOSD) Developing Macrophage Activation Syndrome/Secondary HLH (MAS/sHLH) Completed
  3. N/A Evaluation of IFNγ and Inflammatory Mediators in Patients With Malignancy-Associated Hemophagocytic Lymphohistiocytosis Completed

Showing the 9 most-cited and recently-updated of 9 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Novel NBAS variants define severe immune dysregulation and poor prognosis in infantile liver failure syndrome type 2
Diabetes & Endocrinology Sys. Review
Novel NBAS variants define severe immune dysregulation and poor prognosis in infantile liver failure syndrome type 2 A Chinese girl reveals new genetic causes for severe infant liver failure and immune problems
This case report with systematic review examines NBAS-related disease across 322 previously reported patients. The authors identify novel co…
New genetic findings explain severe liver failure and immune issues in infants, offering hope for earlier diagnosis and care.
Frontiers Jun 2, 2026
Retrospective cohort of 110 children with secondary HLH treated with HLH-94/04 protocol
Psychiatry Cohort
Retrospective cohort of 110 children with secondary HLH treated with HLH-94/04 protocol Young kids with fever and swollen glands need urgent new care plans
This retrospective cohort analysis included 110 children initially diagnosed with secondary hemophagocytic lymphohistiocytosis (sHLH) at a s…
A dangerous immune reaction in toddlers often starts with a cold virus, and new signs help doctors catch it before organs shut down.
Frontiers Apr 25, 2026
R-CHOP immunochemotherapy associated with symptom resolution and complete metabolic response in a case of intravascular large B-cell lymphoma
Rheumatology Cohort
R-CHOP immunochemotherapy associated with symptom resolution and complete metabolic response in a case of intravascular large B-cell lymphoma High Fever and High Ferritin May Signal Rare Blood Cancer
This case report and literature review describes a 60-year-old woman with intravascular large B-cell lymphoma (IVLBCL), fever of unknown ori…
A rare case suggests a specific lab pattern might help doctors find a hidden blood cancer when standard tests fail.
Frontiers Apr 24, 2026
Case report details antiviral and antifungal treatment in a 42-year-old male with primary HLH and EBV infection
Oncology Sys. Review
Case report details antiviral and antifungal treatment in a 42-year-old male with primary HLH and EBV infection A 42-Year-Old Man’s Fever Had a Hidden Genetic Cause
This case report with literature review describes a 42-year-old male with primary hemophagocytic lymphohistiocytosis (HLH) and Epstein–Barr …
This case shows that adults with severe infections may have a hidden genetic immune disorder, changing how doctors look for the cause.
Frontiers Apr 23, 2026
Retrospective cohort of 162 HLH patients shows combined therapy improves survival over monotherapy
Allergy & Immunology Cohort
Retrospective cohort of 162 HLH patients shows combined therapy improves survival over monotherapy Study links certain factors to survival in patients with hemophagocytic lymphohistiocytosis
This retrospective cohort study analyzed 162 patients with hemophagocytic lymphohistiocytosis (HLH) diagnosed across four medical centers.
Survival rates for hemophagocytic lymphohistiocytosis patients improved when combined therapy regimens were used instead of single treatment…
Frontiers Apr 16, 2026