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Hepatitis A

Part of Hepatitis

8 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Hepatitis A

22 trials tracked for Hepatitis A: 20 in phase 3 or 4.

22Trials tracked
20Phase 3 & 4
0Recruiting
0With published results
Phase distribution
Phase 4 9 Phase 3 11 Phase 2 1 Other / NA 1
  1. Phase 4 Effect of Risk Factors Likely to Influence Immuno of Combined Hepatitis A & B Vacc vs Monovalent Hepatitis A & B Vacc Completed
  2. Phase 4 Long-term Persistence Study in Healthy Adults Previously Vaccinated With Twinrix Adult Completed
  3. Phase 4 Evaluation of Antibody Persistence & Immune Memory in Subjects Vaccinated During Adolescence With Twinrix™ Completed
  4. Phase 4 Antibody Persistence & Immune Memory in Healthy Adults Previously Vaccinated With Twinrix Adult Completed
  5. Phase 4 Long-Term Immune Persistence of GlaxoSmithKline Biologicals' Inactivated Hepatitis A Vaccine Injected According to a 0, 12-month Schedule Completed
  6. Phase 4 Hepatitis A Vaccine, Inactivated and Measles, Mumps, Rubella and Varicella Virus Vaccine Live Safety Study (V251-066)(COMPLETED) Completed
Show 16 more trials
  1. Phase 4 A Study to Evaluate the Safety and Immunogenicity of the Hepatitis A Virus Vaccine HAVpur in Healthy Young Children Completed
  2. Phase 4 Evaluation of Immune Memory to Twinrix or Comparator by Challenge Dose Administration 4 Years After Primary Vaccination Completed
  3. Phase 4 Long-Term Immune Persistence of GlaxoSmithKline Biologicals' Inactivated Hepatitis A Vaccine, Injected According to 0, 6-month Schedule Completed
  4. Phase 3 Immune Response & Safety of a Hepatitis A Vaccine Given Together With a Pneumococcal Vaccine in Healthy Children 15 m of Age Completed
  5. Phase 3 Immunogenicity and Safety of Havrix™ Co-Administered With a Diphtheria, Tetanus and Pertussis and a Haemophilus b Vaccine in Children Aged 15 Months Completed
  6. Phase 3 Long-Term Immune Persistence of GSK Biologicals' Combined Hepatitis A & B Vaccine Injected According to a 0,1,6 Month Schedule Completed
  7. Phase 3 Long-term Immune Persistence of GSK Biologicals' Combined Hepatitis A & B Vaccine Injected According to a 0,1,6 Mth Schedule in Healthy Adults Completed
  8. Phase 3 A Study of 2 Doses of VAQTA™ in Healthy Children 12 to 23 Months of Age (V251-069) Completed
  9. Phase 3 Long-Term Follow-Up Studies at Year 6, 7, 8, 9, 10: 2 Formulations of Combined Hepatitis A/B Vaccine Compared in Subjects Aged 12-15 Years Completed
  10. Phase 3 Immunogenicity & Safety of Hepatitis A Vaccine Co-admin With a Measles/Mumps/Rubella & a Varicella Vaccine in Children Completed
  11. Phase 3 Study to Evaluate the Safety and Immunogenicity of Combined Hepatitis A/B Vaccine With MenACWY-CRM Conjugate Vaccine Completed
  12. Phase 3 Study of ChimeriVax™-Japanese Encephalitis Vaccine in Toddlers in Thailand and the Philippines Completed
  13. Phase 3 Long Term Follow-up Study at Years 2, 3, 4 and 5 Where 2 Dosing Schedules of the Combined Hepatitis A and B Vaccine Were Compared Completed
  14. Phase 3 Long-Term Immune Persistence of GSK Biologicals' Combined Hepatitis A & B Vaccine Injected According to a 0,6 Month Schedule Completed
  15. Phase 2 Immunogenicity and Safety of ChimeriVax™ Japanese Encephalitis Vaccine in Thai Toddlers and Children Completed
  16. N/A A Randomized Trial of Vaccine Adherence in Young Injection Drug Users Completed

Showing the 22 most-cited and recently-updated of 22 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.

Research across Hepatitis

Related studies from across the Hepatitis family.

Elevated serum M2BPGi is associated with a 4.61 hazard ratio for hepatocellular carcinoma development
Rheumatology Meta-analysis
Elevated serum M2BPGi is associated with a 4.61 hazard ratio for hepatocellular carcinoma development Elevated M2BPGi Levels Linked to Higher Risk of Liver Cancer
This systematic review and meta-analysis of 12,161 participants found that elevated serum M2BPGi is significantly associated with an increas…
A large review of over 12,000 patients found that high levels of a specific protein may signal an increased risk for liver cancer.
Dolutegravir and lamivudine achieved 78% HIV-1 RNA suppression in patients with isolated reactive anti-HBc
Infectious Disease RCT
Dolutegravir and lamivudine achieved 78% HIV-1 RNA suppression in patients with isolated reactive anti-HBc Trial shows dolutegravir and lamivudine are safe for patients with HIV
This pooled analysis of Phase 3/3b trials evaluated dolutegravir/lamivudine (DTG/3TC) in adults with HIV-1 and isolated reactive hepatitis B…
A review of multiple trials shows that a common two-drug regimen effectively manages HIV while remaining safe for those with hepatitis B ant…
Susceptibility-guided combination therapy improves neurological status and reduces abscess size in a patient with nocardiosis
Hematology Meta-analysis
Susceptibility-guided combination therapy improves neurological status and reduces abscess size in a patient with nocardiosis Case report: Brain infection in autoimmune hepatitis patient
This case report describes the management of disseminated nocardiosis in a 55-year-old man with autoimmune hepatitis. The patient showed gra…
A man with autoimmune hepatitis developed a rare brain infection after immunosuppression. Doctors treated it successfully with targeted anti…
Direct-acting antivirals achieve 89% sustained virologic response in patients with hepatocellular carcinoma and HCV
Oncology Meta-analysis
Direct-acting antivirals achieve 89% sustained virologic response in patients with hepatocellular carcinoma and HCV Direct-acting antivirals show promise for patients with liver cancer
This meta-analysis of 8,839 patients with hepatocellular carcinoma (HCC) and Hepatitis C virus infection found that direct-acting antivirals…
New data suggests that direct-acting antiviral drugs may improve survival and reduce cancer recurrence for people with Hepatitis C and liver…
JAK inhibitors are associated with higher hepatitis B virus reactivation rates than IL-12/23 or IL-17 inhibitors
Gastroenterology Meta-analysis
JAK inhibitors are associated with higher hepatitis B virus reactivation rates than IL-12/23 or IL-17 inhibitors Specific Immune Inhibitors Show Varying Risks for Hepatitis B Reactivation
This meta-analysis of 29 studies evaluated the risk of hepatitis B virus reactivation (HBVr) in patients receiving various immunomodulators.…
New analysis shows that certain immune inhibitors like JAK inhibitors may carry a higher risk of hepatitis B reactivation than other drug cl…
HBeAg seroclearance in HBeAg-positive chronic hepatitis B correlates with disease remission and reduced hepatocellular carcinoma risk
Infectious Disease Sys. Review
HBeAg seroclearance in HBeAg-positive chronic hepatitis B correlates with disease remission and reduced hepatocellular carcinoma risk Clearing HBeAg helps manage chronic hepatitis B and liver risk
This systematic review examines the clinical significance and optimization strategies of HBeAg seroclearance in patients with HBeAg-positive…
Achieving HBeAg seroclearance in patients with chronic hepatitis B can lead to disease remission and a lower risk of developing liver cancer…
Autoimmune hepatitis pathogenesis shifts from single molecule to immune-metabolic network analysis
Drug Pipeline Sys. Review
Autoimmune hepatitis pathogenesis shifts from single molecule to immune-metabolic network analysis New Research Maps Complex Networks in Autoimmune Hepatitis
This systematic review reframes autoimmune hepatitis (AIH) pathogenesis from a single-molecule perspective to a systematic regulatory networ…
Researchers are moving beyond single-molecule views to map complex immune and metabolic networks that drive autoimmune hepatitis.
Evaluating the Impact of Digital Health Interventions on Chronic Disease Self-Care Outcomes
Physical Medicine & Rehab Meta-analysis
Evaluating the Impact of Digital Health Interventions on Chronic Disease Self-Care Outcomes Digital health tools show mixed results for managing chronic diseases
Digital tools show promise for heart failure monitoring but lack consistent evidence for improving medication adherence or general diabetes …
New data shows that while digital tools like apps can help heart failure patients monitor their health, they may not improve medication habi…
Epigallocatechin-3-gallate shows positive therapeutic effects on various digestive system diseases in animal models
Oncology Meta-analysis
Epigallocatechin-3-gallate shows positive therapeutic effects on various digestive system diseases in animal models Green tea compound shows potential for several digestive diseases
This meta-analysis of 63 preclinical studies involving 738 animals indicates that Epigallocatechin-3-gallate (EGCG) has a positive therapeut…
A review of animal studies suggests a green tea compound could help treat various cancers and digestive conditions.
HLA-B*57:01-guided abacavir prescribing is the clearest preventive paradigm from HLA associations
Drug Pipeline Sys. Review
HLA-B*57:01-guided abacavir prescribing is the clearest preventive paradigm from HLA associations HLA genes shape HIV and hepatitis vaccine responses and drug reactions
This narrative review examines HLA polymorphisms in HIV, hepatitis C, and hepatitis B. The clearest preventive paradigm is HLA-B*57:01-guide…
A review finds that HLA genes strongly influence how people respond to HIV and hepatitis vaccines and how they react to certain medications.
PEG-IFN plus novel agents may boost functional cure in chronic hepatitis B
Infectious Disease Sys. Review
PEG-IFN plus novel agents may boost functional cure in chronic hepatitis B Combination therapies may improve functional cure rates for chronic hepatitis B
This narrative review examines combining pegylated interferon-α with novel immunotherapies (antigen-reduction strategies, therapeutic vaccin…
A review suggests combining pegylated interferon with new immunotherapies could help achieve functional cure in chronic hepatitis B patients…
Chronic HCV infection drives T cell dysfunction, regulatory T cell accumulation, and metabolic defects that persist after viral clearance
Allergy & Immunology Sys. Review
Chronic HCV infection drives T cell dysfunction, regulatory T cell accumulation, and metabolic defects that persist after viral clearance Immune defects in hepatitis C may last after the virus is gone
This narrative review examines immune mechanisms in patients with chronic hepatitis C virus infection. The authors describe how prolonged an…
A review explains how chronic hepatitis C causes lasting immune changes that persist even after the virus is cleared, suggesting new treatme…

Questions about Hepatitis A

What details are available about the recent Hepatitis A outbreak in the United States?

Recent data shows a sharp rise in Hepatitis A cases across the U.S., with outbreaks linked to contaminated food, water, and specific geographic areas like Los Angeles County.

Full answer →
What role did molecular testing play in the Los Angeles County Hepatitis A outbreak?

Molecular testing identified the specific strain of the virus in Los Angeles County, confirming the outbreak was caused by a single source and allowing officials to trace the spread to wastewater contamination.

Full answer →
What are the new Hepatitis A immunization recommendations for the United States?

New recommendations focus on vaccinating adults at risk, including those who use drugs, are homeless, or have chronic liver disease, due to a major shift in how the virus spreads.

Full answer →