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Hysterectomy

1 published article · Updated continuously

Clinical Trial Landscape

Clinical Trials for Hysterectomy

10 trials tracked for Hysterectomy: 6 in phase 3 or 4 and 3 with published results. The most-cited published study has 372 citations.

10Trials tracked
6Phase 3 & 4
0Recruiting
3With published results
Phase distribution
Phase 4 3 Phase 3 3 Other / NA 4
  1. Phase 3 ESP Block VS TAP in Laparoscopic Hysterectomy Completed · 372 cited
  2. Phase 4 Mixture of Liposomal Bupivacaine and Bupivacaine for TAP Block for Open Hysterectomy Completed · 27 cited
  3. Phase 4 RCT Superior Hypogastric Block During LH Completed · 17 cited
  4. Phase 4 B&O for TLH Post-operative Pain and Nausea Completed
  5. Phase 3 Efficacy and Safety of Intravenous Acetaminophen Over 48 Hrs for the Treatment of Post-op Pain After Gynecologic Surgery Completed
  6. Phase 3 A Study to Evaluate the Efficacy and Safety of Tapentadol (CG5503) in the Treatment of Acute Pain After Abdominal Hysterectomy Completed
Show 4 more trials
  1. N/A Superior Hypogastric Blockade for Postoperative Pain Completed
  2. N/A Implementing Enhanced Recovery After Surgery (ERAS) Pathways In Major Gynecologic Oncology Operations In Greece Completed
  3. N/A Abdominal Ice Packs for Pain Control and Reduction of Narcotic Use Following Laparoscopic Hysterectomy Completed
  4. N/A Ultravision Visual Clearing System in Laparoscopic Hysterectomy and Myomectomy Completed

Showing the 10 most-cited and recently-updated of 10 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

What the trials found For clinicians

Hysterectomy: what the trials found

Bupivacaine and liposomal bupivacaine have been evaluated for postoperative pain management in hysterectomy patients. Bupivacaine was associated with specific metrics regarding opioid consumption (208, 203, or 202 mg morphine equivalents) and time to first opioid dose (51, 63, or 51 hours) 1. Liposomal bupivacaine demonstrated low Visual Analogue Scale (VAS) pain scores at rest over a 48-hour period, ranging from 2.1 to 3 4.

Morphine was shown to significantly impact the sum of pain intensity differences relative to baseline (p<0.0001) 6. Additionally, IV Acetaminophen (1 Gram) showed comparable results to placebo in the sum of pain intensity at rest from baseline to 24 hours (1793.3 vs 1845.3) and 48 hours (3612.4 vs 3718.2) 5.

Belladonna Opium was studied for post-operative pain, where VAS scores were recorded at 4.1 and 4.8 (p=0.17), and narcotic use was recorded at 19.3 and 21.3 (p=0.29) 3. Bupivacaine Hydrochloride 0.25% injection solution resulted in postoperative pain scores ranging between 5 and 6.3 2.

Recent results — preliminary, needs further review

  • ERAS protocol 7
  • Ice packs plus usual post-op analgesia (Numeric Pain Intensity Scale: 3; 3, p=0.39; MME consumption: 7.5 vs 12, p=0.88) 8
  • Ultravision System (Hospital stay <24 hours: 15; 15; 5) 9
  • Superior hypogastric block (Postoperative Pain Scores: 4.76; 7.38; 3.7; 6.66; 1.9; 4.23) 10

For the clinician treating this condition

  • Bupivacaine and liposomal bupivacaine are established interventions for managing postoperative pain, with liposomal bupivacaine showing low VAS scores at rest through 48 hours.
  • Morphine significantly reduces the sum of pain intensity differences relative to baseline compared to other groups (p<0.0001).
  • IV Acetaminophen (1 Gram) showed no statistically significant difference from placebo in total pain intensity over 24 or 48 hours.

AI synthesis of 10 cited trials, updated Jun 26, 2026. Informational only — not medical advice; trial data sourced from ClinicalTrials.gov. How we use AI.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.