Research across Sepsis
Related studies from across the Sepsis family.
Bleeding, sepsis, and liver impairment each independently raise thrombocytopenia risk in ICU patients
Critical illness factors linked to lower platelet counts in patients
This meta-analysis of 27,147 critically ill patients found that bleeding (OR 3.49), sepsis (OR 2.32), and impaired liver function (OR 1.55) …
New data shows that bleeding, sepsis, and liver issues significantly increase the risk of low platelets in critically ill patients.
Age, male sex, low BMI, and comorbidities like diabetes are significant risk factors for sepsis incidence
Age, diabetes, and COPD raise sepsis risk, meta-analysis finds
This meta-analysis of 21 studies identifies several significant risk factors associated with increased sepsis incidence, including age over …
A new analysis of 21 studies pinpoints key risk factors for sepsis, including age, diabetes, and COPD.
Early postnatal antibiotic exposure increases BPD risk in very preterm infants across 11 studies
Early Antibiotic Exposure Linked to Risks for Very Preterm Infants
This meta-analysis of 11 studies indicates that early postnatal antibiotic exposure is associated with an increased risk of bronchopulmonary…
Early antibiotic use in very preterm infants is linked to higher risks of lung issues, intestinal damage, and mortality.
Toll-like receptor signaling governs inflammatory phenotypes and progression in infectious myocarditis
Toll-like receptors shape severity of infectious myocarditis
This systematic review examines the role of toll-like receptors (TLRs) in infectious myocarditis associated with COVID-19, influenza, and se…
A systematic review finds that pathogen-specific TLR signaling determines inflammation and outcomes in infectious myocarditis, with COVID-19…
HMGB1 and LPS interactions provide potential therapeutic targets for inflammation and coagulation in sepsis
New research identifies how specific proteins drive sepsis inflammation
This narrative review explores the mechanistic roles of Lipopolysaccharide (LPS) and High Mobility Group Box 1 (HMGB1) in sepsis. The author…
Scientists have identified a specific interaction between two molecules that triggers severe inflammation and organ failure during sepsis.
Sepsis is an inflammation-driven immune reprogramming disorder characterized by time-resolved trajectories and biologically defined subtypes
New research reframes sepsis as an immune reprogramming disorder
This narrative review explores the pathophysiology of sepsis as a dynamic immune reprogramming disorder involving hyperinflammation and low-…
Sepsis is more than just a severe infection; it is now being understood as a complex failure of the body's immune system.
Adrenergic receptor signaling modulates pulmonary innate immunity and barrier integrity in acute lung injury
Understanding How Nerve Signals Influence Lung Health During Severe Respiratory Infections
This systematic review synthesizes the role of adrenergic receptors (ARs) as a molecular interface between the sympathetic nervous system an…
New research explores how specific nerve signals help control inflammation and protect the lungs during severe lung infections.
Hyperoxygenation target (PaO2: 100-150 mmHg) reduces 28-day mortality in patients with sepsis
Higher oxygen targets may lower death rates for sepsis patients
This randomized controlled trial of 270 patients with sepsis found that a hyperoxygenation target of PaO2: 100-150 mmHg significantly reduce…
A new trial shows that giving higher levels of oxygen to patients with sepsis can significantly reduce deaths within the first 28 days.
Lactobacillus rhamnosus GG does not significantly impact composite outcomes in VLBW infants
Trial shows probiotic LGG does not improve outcomes for infants
This randomized controlled trial of 236 enterally-fed very low birth weight infants found no significant difference in the primary composite…
A trial of 236 very low birth weight infants found that a specific probiotic did not reduce risks like sepsis or intestinal issues.
Novel biomarkers and machine learning algorithms facilitate earlier identification and diagnosis of sepsis
New Diagnostic Tools May Help Identify Sepsis More Quickly
This narrative review explores the evolution of sepsis diagnostic strategies from traditional clinical scoring systems to advanced markers l…
Newer biomarkers and machine learning tools are evolving beyond traditional scoring systems to help doctors identify sepsis earlier in patie…
Bovine milk fortifiers non-inferior to human milk fortifiers for NEC and sepsis in pre-term newborns
Bovine Milk Fortifiers Show Similar Results to Human Milk
This meta-analysis of 3371 publications found that bovine milk-based fortifiers are non-inferior to human milk-based fortifiers for necrotiz…
A large review of research suggests that bovine milk based fortifiers are as safe and effective as human milk for newborns with specific con…
Elevated HMGB1 levels correlate with sepsis diagnosis and increased mortality risk in adult patients
High HMGB1 levels linked to sepsis and higher mortality
This meta-analysis of 3,110 patients found that serum or plasma HMGB1 levels are significantly higher in sepsis patients compared to healthy…
Higher levels of the protein HMGB1 in the blood are linked to more severe cases of sepsis and an increased risk of death for patients.