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Invasive candidiasis

Part of Fungal infection

2 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Invasive candidiasis

12 trials tracked for Invasive candidiasis: 7 in phase 3 or 4 and 1 with published results. The most-cited published study has 179 citations.

12Trials tracked
7Phase 3 & 4
0Recruiting
1With published results
Phase distribution
Phase 4 2 Phase 3 5 Phase 2 3 Other / NA 2
  1. Phase 3 Isavuconazole (BAL8557) in the Treatment of Candidemia and Other Invasive Candida Infections Completed · 179 cited
  2. Phase 4 This Is An Open-Label, Non-Comparative Study Designed To Evaluate A Short Course Of IV Anidulafungin, Followed Optionally By Oral Voriconazole, For The Treatment Of Candidemia And Invasive Candidiasis Completed
  3. Phase 4 Randomized Study of Caspofungin Prophylaxis Followed by Pre-emptive Therapy for Invasive Candidiasis in the Intensive Care Unit (ICU) Completed
  4. Phase 3 Open-Label Study to Evaluate the Efficacy and Safety of Oral Ibrexafungerp (SCY-078) in Patients With Candidiasis Caused by Candida Auris (CARES) Completed
  5. Phase 3 Study to Evaluate the Efficacy and Safety of Ibrexafungerp in Patients With Fungal Diseases That Are Refractory to or Intolerant of Standard Antifungal Treatment Completed
  6. Phase 3 A Multicenter, Randomized, Double-Blind, Comparative Study to Evaluate the Safety, Tolerability, and Efficacy of 2 Dosing Regimens of an Antifungal Drug in the Treatment of Fungal Infections in Adults (0991-801)(COMPLETED) Completed
Show 6 more trials
  1. Phase 3 Anidulafungin Candidemia/Invasive Candidiasis Intensive Care Study Completed
  2. Phase 2 Oral Ibrexafungerp (SCY-078) vs Standard-of-Care Following IV Echinocandin in the Treatment of Invasive Candidiasis Completed
  3. Phase 2 A Study of Caspofungin (MK-0991) in Japanese Children and Adolescents With Documented Candida or Aspergillus Infections (MK-0991-074) Completed
  4. Phase 2 CD101 Compared to Caspofungin Followed by Oral Step Down in Subjects With Candidemia and/or Invasive Candidiasis-Bridging Extension Completed
  5. N/A Invasive Candidiasis in Saudi ICUs Completed
  6. N/A β-D-Glucan (BDG) Surveillance With Preemptive Anidulafungin vs. Standard Care for Invasive Candidiasis in Surgical Intensive Care Unit (SICU) Patients Completed

Showing the 12 most-cited and recently-updated of 12 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

What the trials found For clinicians

Invasive candidiasis: what the trials found

Clinical evaluations of invasive candidiasis show varying success rates across different antifungal agents. Isavuconazole demonstrated overall response success rates at the end of intravenous therapy (EOIV) of 60.3% and 71.1% 3. Anidulafungin showed a global treatment response success rate of 69.5% at the end of treatment, with 70.7% success at EOIV and 60.2% success two weeks after treatment 6.

Caspofungin was evaluated in multiple studies; one trial reported an overall favorable response to therapy of 66.7% and 62.5% 10, while another study confirmed its use for the condition 7. Ibrexafungerp showed global response rates varying by enrollment category, including results of 74%, 41%, 13%, 95%, 29%, and 10% 4.

Early-phase data for SCY-078 indicated a 21% global success rate at the end of treatment with only a 1% recurrence rate of baseline fungal infection 5, while another study also evaluated this agent 8. Laboratory data for anidulafungin showed specific changes in chemistry laboratory test data, though these values varied across different metrics 2.

Recent results — preliminary, needs further review

  • CD101 was evaluated in a Phase 2 trial (N=207), but results are not yet corroborated.
  • Preemptive therapy with Anidulafungin was studied in a non-phased trial, but results are not yet corroborated.

For the clinician treating this condition

  • Isavuconazole and Anidulafungin both demonstrate high rates of global treatment success at the end of intravenous therapy (60.3% to 71.1% and 69.5% to 70.7%, respectively) [3, 6].
  • Caspofungin is associated with an overall favorable response rate of approximately 62.5% to 66.7% in clinical settings 10.
  • Ibrexafungerp shows highly variable global response rates depending on the specific patient enrollment category 4.

AI synthesis of 8 cited trials, updated Jun 29, 2026. Informational only — not medical advice; trial data sourced from ClinicalTrials.gov. How we use AI.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.

Research across Fungal infection

Related studies from across the Fungal infection family.